Epigenetics in neurodegenerative disorders induced by pesticides

Yu, Guangxia; Su, Qianqian; Chen, Yao; Wu, Lingyan; Wu, Siying; Li, Huangyuan

doi:10.1186/s41021-021-00224-z

Cited by 22 publications

(13 citation statements)

References 102 publications

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“…DNA methylation possesses a critical role in maintaining cognitive functions through gene regulation and other mechanisms in the CNS . DNMTs, such as DNMT1, DNMT3A, and DNMT3B, catalyze DNA methylation by transferring methyl groups from the methyl donor SAM to certain DNA bases .…”

Section: Resultsmentioning

confidence: 99%

“…27 According to these studies, our findings showed that the LPS-treated adverse effects, such as the elevated levels DNA methylation possesses a critical role in maintaining cognitive functions through gene regulation and other mechanisms in the CNS. 30 DNMTs, such as DNMT1, DNMT3A, and DNMT3B, catalyze DNA methylation by transferring methyl groups from the methyl donor SAM to certain DNA bases. 31 While DNMT3A and DNMT3B are primarily in charge of producing new methylation patterns, DNMT1 is primarily in charge of maintaining current methylation patterns.…”

Section: Walnut-derived Peptides Prevented the Generation And Express...mentioning

confidence: 99%

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Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Zhao

Bordoni

Min

et al. 2023

J. Agric. Food Chem.

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Epigenetic mechanisms that dysregulate gene expressions may play a significant role in the development of neurological disorders. However, whether peptides can modulate epigenetic mechanisms remains elusive. This work aimed to investigate the impact of pretreatment with walnut-derived peptidesWHP and YVLLPSPKon DNA methylation in a low-grade neuroinflammation model. The enriched KEGG pathways included oxidative phosphorylation, riboflavin metabolism, ribosome, and pyrimidine metabolism, which are associated with methylation modification by oral administration of YVLLPSPK in mice with scopolamine-induced cognitive deficits. Furthermore, when THP-1 cells (human acute monocytic leukemia cell line) were exposed to lipopolysaccharide (LPS)-induced inflammation responses, both WHP and YVLLPSPK markedly inhibited the level of Il-6 to 2.05 ± 0.76 and 1.29 ± 0.19 (p < 0.05) and also declined the mRNA expression of Mcp-1 to 1.64 ± 0.02 and 3.29 ± 1.21 (p < 0.01), respectively. Meanwhile, YVLLPSPK decreased the activities of DNA methyltransferases (DNMTs) to 1.03 ± 0.02 and 1.20 ± 0.31 (p < 0.05) based on Dnmt3b and Tet2, respectively. The results indicated that YVLLPSPK modulated DNA methylation in embryonic and neural precursor cells in creating new methylation patterns. Further trials are needed to assess the mechanisms underlying DNA methylation changes through peptides in the pathophysiology of neurological disorders.

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Section: Resultsmentioning

confidence: 99%

Section: Walnut-derived Peptides Prevented the Generation And Express...mentioning

confidence: 99%

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Zhao

Bordoni

Min

et al. 2023

J. Agric. Food Chem.

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“…The nucleosome consists of 147 bp of DNA wrapped around an octamer of histones composed of two H3/H4 dimers and two H2A/H2B dimers [ 33 ]. The dynamic and reversible modifications of histone proteins influence all DNA-based processes, including DNA packaging and chromatin compaction, nucleosome dynamics, and transcription [ 76 , 77 ]. This process is regulated by several post-translational modifications, most of which occur within the amino terminal in histone tails [ 78 ].…”

Section: Histone Modificationsmentioning

confidence: 99%

Epigenome Modulation Induced by Ketogenic Diets

et al. 2022

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Ketogenic diets (KD) are dietary strategies low in carbohydrates, normal in protein, and high, normal, or reduced in fat with or without (Very Low-Calories Ketogenic Diet, VLCKD) a reduced caloric intake. KDs have been shown to be useful in the treatment of obesity, metabolic diseases and related disorders, neurological diseases, and various pathological conditions such as cancer, nonalcoholic liver disease, and chronic pain. Several studies have investigated the intracellular metabolic pathways that contribute to the beneficial effects of these diets. Although epigenetic changes are among the most important determinants of an organism’s ability to adapt to environmental changes, data on the epigenetic changes associated with these dietary pathways are still limited. This review provides an overview of the major epigenetic changes associated with KDs.

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“…Both epidemiologic and experimental studies have evidenced that pesticides exposure affects central nervous systems, probably via epigenetic modifications ( Yu et al, 2021 ), such as up-regulation of miRNA-181 that drives the neuronal cells apoptosis as observed by Zhao et al (2019) in a neuroblastoma cell line. miRNA-181 up-regulation leads to increased oxidative stress, altered neurotransmitter status, neuroinflammation, neurodegeneration, and neuronal apoptosis.…”

Section: Pathogenic Mechanism Of Pesticides In Neurodegenerationmentioning

confidence: 99%

Medicinal herbs and multiple sclerosis: Overview on the hard balance between new therapeutic strategy and occupational health risk

Costantini

Masciarelli²,

Casorri³

et al. 2022

Front. Cell. Neurosci.

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Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and axonal loss of the central nervous system (CNS). Despite its spread throughout the world, the mechanisms that determine its onset are still to be defined. Immunological, genetic, viral, and environmental factors and exposure to chemicals may trigger MS. Many studies have highlighted the anti-inflammatory and anti-oxidant effects of medicinal herbs, which make them a natural and complementary treatment for neurodegenerative diseases. A severe reduction of several MS symptoms occurs with herbal therapy. Thus, the request for medicinal plants with potential beneficial effects, for MS patients, is constantly increasing. Consequently, a production increase needs. Unfortunately, many medicinal herbs were untested and their action mechanism, possible adverse effects, contraindications, or interactions with other drugs, are poorly or not investigated. Keeping in mind the pathological mechanisms of MS and the oxidative damages and mitochondrial dysfunctions induced by pesticides, it is important to understand if pesticides used to increase agricultural productivity and their residues in medicinal plants, may increase the risk of developing MS in both workers and consumers. Studies providing some indication about the relationship between environmental exposure to pesticides and MS disease incidence are few, fragmentary, and discordant. The aim of this article is to provide a glance at the therapeutic potential of medicinal plants and at the risk for MS onset of pesticides used by medicinal plant growers and present in medicinal herbs.

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Epigenetics in neurodegenerative disorders induced by pesticides

Cited by 22 publications

References 102 publications

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Epigenome Modulation Induced by Ketogenic Diets

Medicinal herbs and multiple sclerosis: Overview on the hard balance between new therapeutic strategy and occupational health risk

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