Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors

Abstract

Purpose Choroid plexus tumors comprise of choroid plexus papilloma (CPP, WHO grade I), atypical choroid plexus papilloma (aCPP, WHO grade II) and choroid plexus carcinoma (CPC, WHO grade III). Molecular events driving the majority of choroid plexus tumors remain poorly understood. Recently, DNA methylation profiling has revealed different epigenetic subgroups. Methods Comprehensive review of epigenetic profiles of choroid plexus tumors in the context of histopathological, genetic, and clinical features. Summary DNA methylation profiling segregates choroid plexus tumors into three distinct epigenetic subgroups: supratentorial pediatric low-risk choroid plexus tumors (CPP and aCPP), infratentorial adult low-risk choroid plexus tumors (CPP and aCPP), and supratentorial pediatric high-risk choroid plexus tumors (CPP and aCPP and CPC). Epigenetic subgrouping provides additional prognostic information in comparison to histopathological grading. Conclusions Epigenetic profiling of choroid plexus tumors can be used for the identification of patients at risk of recurrence and is expected to play a role for treatment stratification and patient management in the context of future clinical trials.

Outcome and molecular analysis of young children with choroid plexus carcinoma treated with non-myeloablative therapy: results from the SJYC07 trial

“…Prior studies have shown that DNA methylation profiling can discriminate between the histological grades of CPTs (ie CPP, aCPP, CPC) often allowing for a more accurate and reproducible means of diagnosis. 4 , 5 , 49 , 50 The methylation class Choroid Plexus Tumor, Pediatric A comprised of mostly histologic CPP or aCPP while class Choroid Plexus Tumor, Pediatric B was enriched with histologic CPCs. 50 In our study, 11 of 12 patients had tumors that clustered with reference class Choroid Plexus Tumor, Pediatric B.…”

“… 4 , 5 , 49 , 50 The methylation class Choroid Plexus Tumor, Pediatric A comprised of mostly histologic CPP or aCPP while class Choroid Plexus Tumor, Pediatric B was enriched with histologic CPCs. 50 In our study, 11 of 12 patients had tumors that clustered with reference class Choroid Plexus Tumor, Pediatric B. The one sample that clustered with subclass A was histologically described to display features of aCPP but judged more compatible with CPC due to mitotic figure counts, Ki-67 and metastatic status.…”

An Overview of Epigenetic Drugs, and Their Virtual Screening Study Retrieved From Zinc Database Along With an Autodock Study of the Best Inhibitor

“…Int J App Pharm, Vol 13, Issue 5, 2021, 122-131 123 patient identification at risk of recurrence, but also play an important role for the treatment stratification and the patient management [31].…”

“…Extracellular activity of CD38 has a wide range of imprecations for NAD+homeostasis in the context of infection, aging and tumor biology [30]. (Thomas et al, 2020) stated that DNA methylation profiling of choroid plexus cancer will aid the understanding of choroid plexus tumor biology, and can not only be used for the…”

Publisher's Note

“…The Publisher regrets that the article by Thomas et al [1], which is part of this Epigenetics of Pediatric Brain Tumors: Clinical Implications colle ction , was published in an earlier issue 148(1):39-45.…”