Epigenetics, essential hypertension and renin–angiotensin system upregulation in the offspring of water-deprived pregnant rats

Millis, Richard M.

doi:10.1038/hr.2009.168

Cited by 2 publications

(2 citation statements)

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“…The RAAS is responsible for producing adaptations to several conditions such as hyponatremia, hyperkalemia, hypertension, hypotension, and acid-base balance [29]. Aldosterone has a plasma half-life of less than 20 minutes and works by binding to the mineralocorticoid receptor where its primary activity involves the maintenance of normal concentrations of the plasma electrolytes sodium, potassium, bicarbonate, and hydrogen ions, as well as extracellular fluid and pH homeostasis [16,28].…”

Section: ↓ = Decrease; ↑ = Increase; + = Activate; -= Inhibitmentioning

confidence: 99%

Aldosterone Synthase Inhibitors and Dietary Interventions: A Combined Novel Approach for Prevention and Treatment of Cardiovascular Disease

Awosika¹,

Khan²,

Adabanya³

et al. 2023

Cureus

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Systemic hypertension (HTN) is the hallmark of cardiovascular disease and the forerunner of heart failure. These associations have been established over decades of research on essential HTN. Advancements in the treatment of patients diagnosed with HTN, consisting of alpha-or beta-adrenergic receptor blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, thiazide, or aldosterone receptor blockers known as anti-mineralocorticoids, in the presence or absence of low sodium salt diets, often fail to control blood pressure adequately to prevent morbidity and mortality. Low sodium diets have had limited success in controlling HTN because low sodium intake is associated with renin-angiotensin-aldosterone system upregulation. Therefore, upregulating aldosterone secretion, sodium, and water retention which, in turn, moves the blood pressure back toward the range of HTN dictated by the baroreceptor reset value, as a compensatory mechanism, especially in resistant HTN. These impediments to blood pressure control in HTN may have been effectively circumvented by the advent of a new class of drugs known as aldosterone synthase inhibitors, represented by baxdrostat. The mechanism of action of baxdrostat as an aldosterone synthase inhibitor demonstrates the inextricable linkage between sodium and blood pressure regulation. Theoretically, combining a low sodium diet with the activity of this aldosterone synthesis inhibitor should alleviate the adverse effect of renin-angiotensin-aldosterone system upregulation. Aldosterone synthesis inhibition should also decrease the oxidative stress and endothelial dysfunction associated with HTN, causing more endothelial nitric oxide synthesis, release, and vasorelaxation. To the best of our knowledge, this is the first systematic review to summarize evidence-based articles relevant to the use of a novel drug (aldosterone synthase inhibitor) in the treatment of HTN and cardiovascular disease. Making the current database of relevant information on baxdrostat and other aldosterone synthase inhibitors readily available will, no doubt, aid physicians and other medical practitioners in their decision-making about employing aldosterone synthase inhibitors in the treatment of patients.

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Section: ↓ = Decrease; ↑ = Increase; + = Activate; -= Inhibitmentioning

confidence: 99%

Aldosterone Synthase Inhibitors and Dietary Interventions: A Combined Novel Approach for Prevention and Treatment of Cardiovascular Disease

Awosika¹,

Khan²,

Adabanya³

et al. 2023

Cureus

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies aimed at identification of such epigenetic factors for hypertension are beginning to accumulate associations of epigenetic events in-volving nephron development, expression of renin-angiotensin system genes, and blood vessel remodeling. [36][37][38][39] However, to address whether epigenetics contributes to the missing heritability of hypertension, it is imperative that study designs be focused on differentiating the "causal" epigenetic factors for hypertension from the "consequential" epigenetic factors associated with hypertension. A recent National Heart, Lung, and Blood Institute working group report 40 further emphasized this aspect of epigenetic research in hypertension and concluded that, though challenging, integration from both model organism research and human epigenetics might be required to pinpoint a causal relationship (and not mere association) of epigenetics with hypertension.…”

Section: Genome-wide Association Studies "Missing Heritability" Andmentioning

confidence: 99%

Molecular Mechanisms of Experimental Salt‐Sensitive Hypertension

Joe

Shapiro

2012

JAHA

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Epigenetics, essential hypertension and renin–angiotensin system upregulation in the offspring of water-deprived pregnant rats

Cited by 2 publications

References 20 publications

Aldosterone Synthase Inhibitors and Dietary Interventions: A Combined Novel Approach for Prevention and Treatment of Cardiovascular Disease

Aldosterone Synthase Inhibitors and Dietary Interventions: A Combined Novel Approach for Prevention and Treatment of Cardiovascular Disease

Molecular Mechanisms of Experimental Salt‐Sensitive Hypertension

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