2016
DOI: 10.1016/j.pharmthera.2016.03.005
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Epigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management

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Cited by 94 publications
(51 citation statements)
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“…Essentially, there are two types of approaches for which this can be achieved: digestion-and antibody-based techniques [31] . It has been determined that the enzyme glucosyltransferase will modify 5-hmC, but not 5 mCbases.…”
Section: Detection Of Hydroxymethyl Cytosinementioning
confidence: 99%
See 2 more Smart Citations
“…Essentially, there are two types of approaches for which this can be achieved: digestion-and antibody-based techniques [31] . It has been determined that the enzyme glucosyltransferase will modify 5-hmC, but not 5 mCbases.…”
Section: Detection Of Hydroxymethyl Cytosinementioning
confidence: 99%
“…It has been determined that the enzyme glucosyltransferase will modify 5-hmC, but not 5 mCbases. Based on this intrinsic difference in their properties as substrates, both New England Bio labs and Zymo Research have developed assay kits for the specific detection of glycosylated 5-hmC.Zymo Research's Quest hmC Detection Kit utilizes hydroxymethylcytosine glucosyltransferase and the substrate uridine diphosphoglucose to selectively glucosylate 5-hmC bases [31] . Importantly, modification of the 5-hmC bases renders these sites of the DNA strand resistant to cleavage by the nuclease MspI.…”
Section: Detection Of Hydroxymethyl Cytosinementioning
confidence: 99%
See 1 more Smart Citation
“…To create therapies that are effective in CAD treatment, it is of most importance to improve our understanding of numerous genetic, as well as epigenetic cues for the onset and development of heart failure [5,6]. …”
Section: Introductionmentioning
confidence: 99%
“…Many fine studies have shown the influence of environment on DNA for embryonic development; but also for the future development of obesity or diabetes, for the development of stress responses, of hypertension or cancer. Therefore epigenetic modifications are to be considered an important mechanism in the etiology of many diseases since the prenatal life [8]. Such induced epigenetic changes can be inherited during cell division in the first phases of life, namely in the first part of the golden 1,000 days, resulting in permanent conservation of the acquired phenotype.…”
Section: Introductionmentioning
confidence: 99%