Epigenetics and its Therapeutic Potential in Colorectal Cancer

Oryani, Mahsa Akbari; Tavasoli, Afsaneh; Ghalavand, Mohammad Amin; Ashtiani, Rahele Zokaei; Rezaee, Alisam; Mahmoudi, Rasadokht; Golvari, Hossein; Owrangi, Soroor; Soleymani-Goloujeh, Mehdi

doi:10.2217/epi-2022-0067

Cited by 5 publications

(1 citation statement)

References 94 publications

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“…In numerous malignant tumors [2][3][4], as well as hematopoietic tumors [5][6][10], epigenetic processes of tumor growth and therapy have been identified. However, unlike solid tumors, the microenvironment of hematopoietic malignancies is more complex.…”

Section: Introductionmentioning

confidence: 99%

A review of aberrant DNA methylation in bone marrow mesenchymal stromal cells: a new possible access of acute myeloid leukemia

Zhang

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

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The bone marrow mesenchymal stromal cells (BMMSCs) play a crucial role in the progression of acute myeloid leukemia (AML). However, the epigenetic landscape of AML patients' BMMSCs is currently not well understood. This paper reviewed the relationship between aberrant DNA methylation in BMMSCs and the development of AML based on the studies conducted by Roux and colleagues. The abnormal DNA methylation may represent a novel access point for AML, but it should be confirmed by additional research. This paper also provides suggestions for further research in this field.

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Section: Introductionmentioning

confidence: 99%

A review of aberrant DNA methylation in bone marrow mesenchymal stromal cells: a new possible access of acute myeloid leukemia

Zhang

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

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Overexpression of circular RNA hsa_circ_0008621 facilitates colorectal cancer progression and predicts poor prognosis

Zhou,

Wu,

Tian

2024

Annals of Gastroent Surgery

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AimTo evaluate the potential role of serum and tissue hsa_circ_0008621 as a prognostic biomarker for CRC patients. Focused on the functional role of hsa_circ_0008621 in colorectal cancer (CRC).MethodsSerum and tissue hsa_circ_0008621 expression were quantified by qRT‐PCR in 157 CRC patients, as well as 100 serums from healthy controls. Serum and tissue hsa_circ_0008621 expression was evaluated for their prognostic role in CRC patients using Kaplan–Meier curves and Multivariate Cox proportional hazards analysis. To further characterize the biological role of hsa_circ_0008621 expression in CRC, in vitro hsa_circ_0008621 inhibition was performed and the effects on cellular growth, migration, invasion, apoptosis, and glycolysis were explored. Next, the downstream molecules for hsa_circ_0008621 were predicted.ResultsHsa_circ_0008621 expression was significantly upregulated in CRC tissues and serums. Serum hsa_circ_0008621 levels were significantly up‐regulated in advanced‐staged samples. High serum hsa_circ_0008621 expression was associated with shorter overall survival and recurrence‐free survival in CRC patients. Multivariate Cox regression analysis identified a high level of serum hsa_circ_0008621 expression as an independent prognostic factor with respect to overall survival and recurrence‐free survival. Loss of function assays for hsa_circ_0008621 in vitro led to a significant decrease in cell proliferation, migration, invasion, and glycolysis, but an increase in cell apoptosis. Hsa_circ_0008621 can sponge miR‐532‐5p, which targets SLC16A3.ConclusionHigh level of serum hsa_circ_0008621 is associated with poor survival in CRC and promotes CRC progression, suggesting it to be a promising non‐invasive prognostic biomarker and novel therapeutic target in CRC patients.

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Recent progress of targeted nanocarriers in diagnostic, therapeutic, and theranostic applications in colorectal cancer

Choudhury,

Pandey,

Saravanan

et al. 2023

Biomaterials Advances

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Epigenetics and its Therapeutic Potential in Colorectal Cancer

Cited by 5 publications

References 94 publications

A review of aberrant DNA methylation in bone marrow mesenchymal stromal cells: a new possible access of acute myeloid leukemia

A review of aberrant DNA methylation in bone marrow mesenchymal stromal cells: a new possible access of acute myeloid leukemia

Overexpression of circular RNA hsa_circ_0008621 facilitates colorectal cancer progression and predicts poor prognosis

Recent progress of targeted nanocarriers in diagnostic, therapeutic, and theranostic applications in colorectal cancer

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