Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study

Gondalia, Rahul; Baldassari, Antoine; Holliday, Katelyn M.; Justice, Anne E.; Stewart, James D.; Liao, Duanping; Yanosky, Jeff D.; Engel, Stephanie M.; Sheps, David S.; Jordahl, Kristina M.; Bhatti, Parveen; Horvath, Steve; Assimes, Themistocles L.; Demerath, Ellen W.; Guan, Weihua; Fornage, Myriam; Bressler, Jan; North, Kari E.; Conneely, Karen N.; Li, Yun; Hou, Lifang; Baccarelli, Andrea A.; Whitsel, Eric A.

doi:10.1016/j.envres.2021.111211

Cited by 5 publications

(5 citation statements)

References 76 publications

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“…The PCR sequencing papers focused on candidate gene approaches (primarily for inflammatory and immune-related proteins, as well as genes related to circadian rhythm and epigenetic age) [ 41 , 50 , 118 , 119 , 120 , 125 , 146 , 147 , 148 , 149 , 150 , 151 , 152 ]. Analyses using arrays took advantage of the evolving technology to capture the most comprehensive set of biomarkers possible: one paper utilized a 385 K array [ 46 ], twenty-four utilized a 450 K array [ 42 , 43 , 44 , 45 , 47 , 48 , 49 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 65 , 66 , 67 , 153 , 154 , 155 , 156 ], and twelve utilized an 850 K array [ 61 , 62 , 63 , 64 , 116 , 117 , 157 , 158 , 159 , 160 , 161 , …”

Section: Resultsmentioning

confidence: 99%

“…Analyses using arrays took advantage of the evolving technology to capture the most comprehensive set of biomarkers possible: one paper utilized a 385 K array [46], twenty-four utilized a 450 K array [42][43][44][45][47][48][49][51][52][53][54][55][56][57][58][59][60][65][66][67][153][154][155][156], and twelve utilized an 850 K array [61][62][63][64]116,117,[157][158][159][160][161][162]. Although we recommend the use of the most comprehensive technology available, the contribution of groundbreaking studies using older arrays to the current body of knowledge should not be understated [163,164].…”

Section: Omics Assessmentmentioning

confidence: 99%

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Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis

Casella,

Kiles,

Urquhart

et al. 2023

Toxics

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A growing body of literature has attempted to characterize how traffic-related air pollution (TRAP) affects molecular and subclinical biological processes in ways that could lead to cardiorespiratory disease. To provide a streamlined synthesis of what is known about the multiple mechanisms through which TRAP could lead to cardiorespiratory pathology, we conducted a systematic review of the epidemiological literature relating TRAP exposure to methylomic, proteomic, and metabolomic biomarkers in adult populations. Using the 139 papers that met our inclusion criteria, we identified the omic biomarkers significantly associated with short- or long-term TRAP and used these biomarkers to conduct pathway and network analyses. We considered the evidence for TRAP-related associations with biological pathways involving lipid metabolism, cellular energy production, amino acid metabolism, inflammation and immunity, coagulation, endothelial function, and oxidative stress. Our analysis suggests that an integrated multi-omics approach may provide critical new insights into the ways TRAP could lead to adverse clinical outcomes. We advocate for efforts to build a more unified approach for characterizing the dynamic and complex biological processes linking TRAP exposure and subclinical and clinical disease and highlight contemporary challenges and opportunities associated with such efforts.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Omics Assessmentmentioning

confidence: 99%

Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis

Casella,

Kiles,

Urquhart

et al. 2023

Toxics

View full text Add to dashboard Cite

show abstract

“…Various environmental stressorsfrom heavy metals to ionizing radiation-are known to affect DNA methylation and DNA methylation machinery [26,37,38]. Exposure to PM, from coarse PM 10 particles to nanoparticles has been associated with altered DNA methylation in vitro, in vivo, and in humans [39][40][41]. Therefore, epigenetic alterations associated with environmental exposures receive much attention as key mechanisms in the pathogenesis of exposure-associated diseases [42,43].…”

Section: Discussionmentioning

confidence: 99%

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

Miousse,

Hale,

Alsbrook

et al. 2023

Sustainability

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Climate change presents multiple challenges to rural communities. Here, we investigated the toxicological potential of the six types of particulate matter most common to rural Arkansas: soil, road, and agricultural dusts, pollen, traffic exhaust, and particles from biomass burning in human small airway epithelial cells (SAECs). Biomass burning and agricultural dust demonstrated the most potent toxicological responses, exhibited as significant (p < 0.05) up-regulation of HMOX1 (oxidative stress) and TNFα (inflammatory response) genes as well as epigenetic alterations (altered expression of DNA methyltransferases DNMT1, DNMT3A, and DNMT3B, enzymatic activity, and DNA methylation of alpha satellite elements) that were evident at both 24 h and 72 h of exposure. We further demonstrate evidence of aridification in the state of Arkansas and the presence of winds capable of transporting agricultural dust- and biomass burning-associated particles far beyond their origination. Partnerships in the form of citizen science projects may provide important solutions to prevent and mitigate the negative effects of the rapidly evolving climate and improve the well-being of rural communities. Furthermore, the identification of the most toxic types of particulate matter could inform local policies related to agriculture, biomass burning, and dust control.

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“…The PCR sequencing papers focused on candidate gene approaches (primarily for inflammatory and immune-related proteins, as well as genes related to circadian rhythm and epigenetic age) [38,47,116,117,120,[140][141][142][143][144][145][146][147]. Analyses using arrays took advantage of the evolving technology to capture the most comprehensive set of biomarkers possible: one paper utilized a 385K array [43], 24 utilized a 450K array [39][40][41][42][44][45][46]48,[50][51][52][53][54][55]57,[62][63][64][148][149][150][151][152][153], and 12 utilized an 850K array [58][59][60][61]114,115,[154][155][156]…”

Section: Omics Assessmentmentioning

confidence: 99%

Methylomic, proteomic, and metabolomic correlates of traffic-related air pollution: A systematic review, pathway analysis, and network analysis relating traffic-related air pollution to subclinical and clinical cardiorespiratory outcomes

Casella,

Kiles,

Urquhart

et al. 2023

Preprint

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A growing body of literature has attempted to characterize how traffic-related air pollution (TRAP) affects molecular and subclinical biological processes in ways that could lead to cardiorespiratory disease. To provide a streamlined synthesis of what is known about the multiple mechanisms through which TRAP could lead cardiorespiratory pathology, we conducted a systematic review of the epidemiological literature relating TRAP exposure to methylomic, proteomic, and metabolomic biomarkers in adult populations. Using the 139 papers that met our inclusion criteria, we identified the omic biomarkers significantly associated with short-or long-term TRAP and used these biomarkers to conduct pathway and network analyses. We considered the evidence for TRAP-related associations with biological pathways involving lipid metabolism, cellular energy production, amino acid metabolism, inflammation and immunity, coagulation, endothelial function, and oxidative stress. Our analysis suggests that an integrated multi-omics approach may provide critical new insights into the ways TRAP could lead to adverse clinical outcomes. We advocate for efforts to build a more unified approach for characterizing the dynamic and complex biological processes linking TRAP exposure and subclinical and clinical disease, and highlight contemporary challenges and opportunities associated with such efforts.

show abstract

Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study

Cited by 5 publications

References 76 publications

Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis

Methylomic, Proteomic, and Metabolomic Correlates of Traffic-Related Air Pollution in the Context of Cardiorespiratory Health: A Systematic Review, Pathway Analysis, and Network Analysis

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters

Methylomic, proteomic, and metabolomic correlates of traffic-related air pollution: A systematic review, pathway analysis, and network analysis relating traffic-related air pollution to subclinical and clinical cardiorespiratory outcomes

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