Epigenética, medio ambiente y asma

Rico-Rosillo, Guadalupe; Vega-Robledo, Gloria Bertha; Silva-García, Raúl; Oliva-Rico, Diego

doi:10.29262/ram.v61i2.32

Cited by 8 publications

(7 citation statements)

References 57 publications

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“…It is well known that the NF‐κB pathway is closely related to the course of asthma . We further elucidated the effect of salidroside on the activation of the NF‐κB pathway by detecting the expressions of p65 and phosphorylated p65 (p‐p65).…”

Section: Resultsmentioning

confidence: 99%

“…It is well known that the NF-κB pathway is closely related to the course of asthma. 14 We further elucidated the effect of salidroside on the activation of the NF-κB pathway by detecting the expressions of p65 and phosphorylated p65 (p-p65). The results of Western blot analysis showed that PDGF caused a significant increase in p-p65 expression but not p65 expression.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

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Salidroside inhibits platelet‐derived growth factor–induced proliferation and migration of airway smooth muscle cells

Tian

et al. 2018

J of Cellular Biochemistry

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Abnormal proliferation and migration of airway smooth muscle cells (ASMCs) have been found to be important for the airway remodeling during the pathogenesis of asthma. Salidroside a bioactive glucoside that exerts antitumor activity via inhibiting the cell proliferation and migration of cancer cells. The aim of the current study was to evaluate the effects of salidroside on the proliferation and migration of ASMCs. Our results showed that salidroside inhibited the proliferation and migration of ASMCs in response to platelet‐derived growth factor (PDGF) stimulation. Salidroside markedly attenuated the PDGF‐induced production of matrix metalloproteinase 2 (MMP‐2) and MMP‐9 in ASMCs. The levels of contractile phenotype markers including smooth muscle α‐actin and calponin were reduced in response to PDGF stimulation, which was attenuated by salidroside pretreatment. Salidroside diminished the increase in the expression levels of type I collagen and fibronectin in PDGF‐stimulated ASMCs. Furthermore, salidroside blocked the PDGF‐induced activation of the nuclear factor‐κB (NF‐κB) pathway in ASMCs. The results suggested that salidroside functionally regulated the proliferation, migration, phenotype plasticity, and extracellular matrix deposition in PDGF‐induced ASMCs and the NF‐κB pathway might be implicated in the effects of salidroside on ASMCs induced by PDGF.

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Section: Resultsmentioning

confidence: 99%

Section: Conflicts Of Interestmentioning

confidence: 99%

Salidroside inhibits platelet‐derived growth factor–induced proliferation and migration of airway smooth muscle cells

Tian

et al. 2018

J of Cellular Biochemistry

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“…Transcription factors are a critical modulator of inflammation in severe asthma and are elevated in severe COPD [37]. The NF-κB activation is associated with inflammation, remodeling, and oxidative stress-caused by various signals, such as cytokines and pathogens-in chronic pulmonary diseases [38]. In the present study, NF-κB was significantly higher in the OVA, ELA, and ACO groups than in the SAL group, was significantly higher in the ELA group than in the ACO group, and was attenuated in the treatment groups in both the airways and the alveolar septa.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Effects of a New Peptide, Derived from the Enterolobium contortisiliquum Proteinase Inhibitor (EcTI), on Inflammation, Remodeling, and Oxidative Stress in an Experimental Mouse Model of Asthma–Chronic Obstructive Pulmonary Disease Overlap (ACO)

Barbosa,

da Silva,

João

et al. 2023

IJMS

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The synthesized peptide derived from Enterolobium contortisiliquum (pep3-EcTI) has been associated with potent anti-inflammatory and antioxidant effects, and it may be a potential new treatment for asthma–COPD overlap—ACO). Purpose: To investigate the primary sequence effects of pep3-EcTI in an experimental ACO. BALB/c mice were divided into eight groups: SAL (saline), OVA (ovalbumin), ELA (elastase), ACO (ovalbumin + elastase), ACO-pep3-EcTI (treated with inhibitor), ACO-DX (treated with dexamethasone), ACO-DX-pep3-EcTI (treated with dexamethasone and inhibitor), and SAL-pep3-EcTI (saline group treated with inhibitor). We evaluated the hyperresponsiveness to methacholine, exhaled nitric oxide, bronchoalveolar lavage fluid (BALF), mean linear intercept (Lm), inflammatory markers, tumor necrosis factor (TNF-α), interferon (IFN)), matrix metalloproteinases (MMPs), growth factor (TGF-β), collagen fibers, the oxidative stress marker inducible nitric oxide synthase (iNOS), transcription factors, and the signaling pathway NF-κB in the airways (AW) and alveolar septa (AS). Statistical analysis was conducted using one-way ANOVA and t-tests, significant when p < 0.05. ACO caused alterations in the airways and alveolar septa. Compared with SAL, ACO-pep3-EcTI reversed the changes in the percentage of resistance of the respiratory system (%Rrs), the elastance of the respiratory system (%Ers), tissue resistance (%Gtis), tissue elastance (%Htis), airway resistance (%Raw), Lm, exhaled nitric oxide (ENO), lymphocytes, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, TNF-α, INF-γ, MMP-12, transforming growth factor (TGF)-β, collagen fibers, and iNOS. ACO-DX reversed the changes in %Rrs, %Ers, %Gtis, %Htis, %Raw, total cells, eosinophils, neutrophils, lymphocytes, macrophages, IL-1β, IL-6, IL-10, IL-13, IL-17, TNF-α, INF-γ, MMP-12, TGF-β, collagen fibers, and iNOS. ACO-DX-pep3-EcTI reversed the changes, as was also observed for the pep3-EcTI and the ACO-DX-pep3-EcTI. Significance: The pep3-EcTI was revealed to be a promising strategy for the treatment of ACO, asthma, and COPD.

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“…El envejecimiento biológico, es producto de la "acumulación de una gran variedad de daños moleculares y celulares a lo largo del tiempo, lo que lleva a un descenso gradual de las capacidades físicas y mentales, un aumento del riesgo de enfermedad, y finalmente a la muerte" 2 . Sin embargo, según Rico-Rosillo et al 7 , la mala calidad de vida, el entorno social y las comorbilidades pueden conducir a un envejecimiento acelerado. Por otro lado, el envejecimiento activo es "un proceso de optimización de las oportunidades de salud, participación y seguridad con el fin de mejorar la calidad de vida a medida que las personas envejecen" 5 .…”

Section: Envejecimientounclassified

Influencia del trabajo del CORE en el desarrollo del equilibrio en la persona adulta mayor

Politanò¹,

Hernández-Moncada²,

Mora-Sandoval³

et al. 2023

Rev Ter

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Introducción: el entrenamiento de la musculatura central del cuerpo (CORE) constituye un elemento de vital importancia en la persona adulta mayor permitiendo desarrollar la fuerza, la resistencia, la flexibilidad y el equilibrio, los cuales son elementos claves para reducir el riesgo de caídas. Objetivo: analizar el efecto del trabajo del CORE en el desarrollo del equilibrio y la disminución del riesgo de caídas en la persona adulta mayor. Metodología: estudio de revisión bibliográfica basado en evidencia sobre la Influencia del trabajo del CORE en el desarrollo del equilibrio en la persona adulta mayor, utilizando bases de datos como: PubMed, Scielo, Elsevier, Tripdatabase, así como los siguientes descriptores y operadores boléanos: CORE AND stability, CORE AND Elder, Adulto mayor AND riesgo, Fisioterapia AND CORE, CORE AND strength adulto mayor, Risk fall AND elderly, Elder AND falls, CORE stability AND adulto mayor, CORE AND adulto mayor. Se eligieron 34 artículos científicos publicados entre el año 2016 al 2021, en idioma español o inglés. Según la clasificación de Sackett el 38,2% tienen un nivel de evidencia 1, 2,9% nivel 2, 14,7% nivel 3, 35,2% nivel 4 y 9% nivel 5. Resultados: los artículos revisados coindicen en la mención de los principales factores relacionados con el riesgo de caídas, en ellos se distinguen los intrínsecos y extrínsecos los cuales se deben de trabajar por medio de programas de entrenamiento que fortalezcan el CORE, incluyendo ejercicios de coordinación, velocidad, fuerza y resistencia como forma de prevención para el riesgo de caídas en el adulto mayor. Conclusiones: la prescripción del ejercicio físico debe ser individualizada y enfocada en el trabajo de velocidad, fuerza y resistencia para así aumentar la musculatura del CORE, mejorar la capacidad funcional, el equilibrio y disminuir el riesgo de caídas.

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Epigenética, medio ambiente y asma

Cited by 8 publications

References 57 publications

Salidroside inhibits platelet‐derived growth factor–induced proliferation and migration of airway smooth muscle cells

Salidroside inhibits platelet‐derived growth factor–induced proliferation and migration of airway smooth muscle cells

Investigating the Effects of a New Peptide, Derived from the Enterolobium contortisiliquum Proteinase Inhibitor (EcTI), on Inflammation, Remodeling, and Oxidative Stress in an Experimental Mouse Model of Asthma–Chronic Obstructive Pulmonary Disease Overlap (ACO)

Influencia del trabajo del CORE en el desarrollo del equilibrio en la persona adulta mayor

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