Epigenetic variations due to nutritional status in early‐life and its later impact on aging and disease

Gómez-Verján, Juan Carlos; Barrera-Vázquez, Oscar Salvador; García‐Velázquez, Lizbeth; Samper‐Ternent, Rafael; Arroyo, Pedro

doi:10.1111/cge.13748

Cited by 16 publications

(12 citation statements)

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“…Furthermore, the strong association between maternal nutritional status and the risk of developing metabolic, cardiovascular and neurological diseases in the offspring [114] , passing through epigenetic alterations [115] , is emphasized by some papers in which micronutrients are examined. For example, some methyl donor micronutrients, such as folate, methionine, choline and betaine play a key role in the regulation of DNA methylation through the folate-mediated one-carbon metabolism processes [116] , [117] .…”

Section: The Effects Of Nutrition On Cognition During the Lifetime: An Overview On Epigenetic Mechanismsmentioning

confidence: 99%

Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

Polverino¹,

Sorrentino²,

Pesoli³

et al. 2021

AIMS Neuroscience

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The functioning of our brain depends on both genes and their interactions with environmental factors. The close link between genetics and environmental factors produces structural and functional cerebral changes early on in life. Understanding the weight of environmental factors in modulating neuroplasticity phenomena and cognitive functioning is relevant for potential interventions. Among these, nutrition plays a key role. In fact, the link between gut and brain (the gut-brain axis) is very close and begins in utero , since the Central Nervous System (CNS) and the Enteric Nervous System (ENS) originate from the same germ layer during the embryogenesis. Here, we investigate the epigenetic mechanisms induced by some nutrients on the cognitive functioning, which affect the cellular and molecular processes governing our cognitive functions. Furthermore, epigenetic phenomena can be positively affected by specific healthy nutrients from diet, with the possibility of preventing or modulating cognitive impairments. Specifically, we described the effects of several nutrients on diet-dependent epigenetic processes, in particular DNA methylation and histones post-translational modifications, and their potential role as therapeutic target, to describe how some forms of cognitive decline could be prevented or modulated from the early stages of life.

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Section: The Effects Of Nutrition On Cognition During the Lifetime: An Overview On Epigenetic Mechanismsmentioning

confidence: 99%

Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

Polverino¹,

Sorrentino²,

Pesoli³

et al. 2021

AIMS Neuroscience

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“…According to the developmental programming of health and disease (DOHaD) hypothesis, the fetal stage is a period of rapid growth, any stimulus during this critical period can permanently alter or “programme” the structure and physiology of the respiratory system with possible long-term consequences ( 35 , 36 ). Another possible mechanism could be that epigenetic changes modify bronchial reactivity and induce alternative phenotypes from the same genotype ( 7 ). Animal models showed that dietary protein restriction and malnutrition during early-life could lead to lower MeDNA levels in promoter regions of the glucocorticoid receptor and peroxisomal proliferator-activated receptor genes in mice offspring, which lead to persistent phenotype changes that could be transmitted to the next generation ( 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…Peak expiratory flow (PEF), which used as an indicator of preliminary diagnosis and prognosis assessment of lung function and respiratory diseases including asthma and COPD, especially for older individuals ( 6 ). Growing evidence reported that exposure to an adverse environment, such as famine, malnutrition, and natural disaster during the critical development period, including in utero , early postnatal stage, or childhood had long-term implications for adult respiratory health ( 7 , 8 ). Several studies indicated that malnutrition in early life, such as insufficient vitamin D level might reduce PEF and influence lung development ( 9 , 10 ), while the mechanisms remained inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Exposure to Malnutrition From the Chinese Famine on Risk of Asthma and Chronic Obstructive Pulmonary Disease in Adulthood

Jin

Zhang

et al. 2022

Front. Nutr.

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ObjectivesIntrauterine malnutrition has a long-term effect on respiratory and lung function. However, few studies have explored the association between early-life exposure to famine with asthma and chronic obstructive pulmonary disease (COPD) in adulthood. Therefore, we aimed to investigate the association of early-life exposure to the Chinese famine of 1959–1962 with asthma and COPD later in life.MethodsThis national population-based study included 6,771 participants from the baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) who were born around the time of the Chinese famine. The famine exposure groups were determined according to the participants' birth year as non-exposed (1964–1967), fetal-exposed (1959–1962), preschool-exposed (1954–1957), and school-age exposed (1950–1953). Information about the demographic characteristics, self-reported doctor-diagnosed asthma and COPD, behavior and lifestyles, and indoor pollution were collected using validated questionnaires. In addition, peak expiratory flow (PEF) was measured to assess pulmonary function. Multivariable logistic regression and generalized linear mixed models were performed to explore the risk of adult asthma and COPD, PEF changes during various famine exposure periods compared with the non-exposed group. Stratified and sensitivity analyses were conducted to examine the modification and robustness of the association.ResultsThe prevalence of doctor-diagnosed asthma and COPD was 2.8 and 8.1%, respectively. Compared with the non-exposed group, the risk was significantly higher in the fetal-exposed group for asthma [adjusted odds ratio, (aOR) = 1.87, 95% confidence interval (CI):1.14–3.07] and the school-age exposed group [1.30 (1.00–1.69)] for COPD after controlling for confounders. Furthermore, we observed that fetal exposure to famine was significantly associated with a decrement of PEF in adulthood [β = −11.38 (−22.75 to −0.02)] compared with the non-exposed group. Stratified analyses showed that the association of asthma was stronger in men, who resided in severely famine-affected areas, smoked, and used solid fuels for cooking. No clearly consistent association was observed for subsequent COPD.ConclusionsOur results suggest that fetal exposure to the Chinese famine is significantly associated with the increased risk of asthma in adulthood. Future prospective studies are warranted to examine the association and mechanisms.

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“…Such efforts are facilitated by studies in living populations that integrate demographic, medical history, psychosocial, epigenetic, and/or cause of death data. Much of the research in living populations on DOHaD focuses on noncommunicable diseases such as cardiovascular disease and diabetes (e.g., Barker, 1990; Gomez‐Verjan et al, 2020), but developmental insults also have the potential to alter immune functioning over the lifespan (MacGillivray & Kollmann, 2014; Palmer, 2011) and to affect mortality risk from infectious disease (Moore et al, 1999). A recent study by Cheng et al (2020) found that prenatal and early life exposure to nutritional stress during the Great Chinese Famine increased the risk of tuberculosis in adulthood across two generations, more clearly indicating a way for bioarchaeologists to examine within‐individual and intergenerational effects of diet and specific, skeletally diagnosable, diseases in the past.…”

Section: Osteological Paradox Dohad and Healthmentioning

confidence: 99%

Twenty‐first century bioarchaeology: Taking stock and moving forward

Buikstra

DeWitte

Baker

et al. 2022

American Journal of Biological Anthropology

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This article presents outcomes from a Workshop entitled “Bioarchaeology: Taking Stock and Moving Forward,” which was held at Arizona State University (ASU) on March 6–8, 2020. Funded by the National Science Foundation (NSF), the School of Human Evolution and Social Change (ASU), and the Center for Bioarchaeological Research (CBR, ASU), the Workshop's overall goal was to explore reasons why research proposals submitted by bioarchaeologists, both graduate students and established scholars, fared disproportionately poorly within recent NSF Anthropology Program competitions and to offer advice for increasing success. Therefore, this Workshop comprised 43 international scholars and four advanced graduate students with a history of successful grant acquisition, primarily from the United States. Ultimately, we focused on two related aims: (1) best practices for improving research designs and training and (2) evaluating topics of contemporary significance that reverberate through history and beyond as promising trajectories for bioarchaeological research. Among the former were contextual grounding, research question/hypothesis generation, statistical procedures appropriate for small samples and mixed qualitative/quantitative data, the salience of Bayesian methods, and training program content. Topical foci included ethics, social inequality, identity (including intersectionality), climate change, migration, violence, epidemic disease, adaptability/plasticity, the osteological paradox, and the developmental origins of health and disease. Given the profound changes required globally to address decolonization in the 21st century, this concern also entered many formal and informal discussions.

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Epigenetic variations due to nutritional status in early‐life and its later impact on aging and disease

Cited by 16 publications

References 122 publications

Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

Early-Life Exposure to Malnutrition From the Chinese Famine on Risk of Asthma and Chronic Obstructive Pulmonary Disease in Adulthood

Twenty‐first century bioarchaeology: Taking stock and moving forward

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