Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

Trosko, James E.; Chang, Chia Cheng; Upham, Brad L.; Wilson, Melinda R.

doi:10.1016/s0378-4274(98)00288-4

Cited by 107 publications

(68 citation statements)

References 36 publications

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“…Gap junction communication (GJC) plays a role in the control of cell growth via differentiation, proliferation, and apoptosis ( 90 ). The central cleavage of lycopene yields acycloretinoic acid (ACR), the linear analog of atRA, which was shown to enhance GJC at supraphysiological concentrations (50 M) in human fetal skin fi broblasts ( 91 ).…”

Section: Biological Activities Of Apolycopenoidsmentioning

confidence: 99%

Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids

Eroglu

Harrison

2013

Journal of Lipid Research

171

148

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Section: Biological Activities Of Apolycopenoidsmentioning

confidence: 99%

Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids

Eroglu

Harrison

2013

Journal of Lipid Research

171

148

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“…12 Recent studies reported that testicular Cx could be molecular targets for the deleterious effect of environmental toxicants on spermatogenesis. [16][17][18] However, to date, there is a lack of information (i) on a reliable link between altered Cx expression and toxicant exposure, (ii) on the developmental window during which Cx is the most sensitive to pollutants and could result in transgenerational reproductive dysfunction and (iii) on the molecular mechanisms by which toxicants impair male reproductive function through Cx disruption. In the present paper, after introducing the physiological role of Cx, its regulation and its testicular function, we propose to give an overview of Cx expression within the developing testis.…”

Section: Introductionmentioning

confidence: 99%

Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility

et al. 2011

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“…), as we, biologically, were never designed to live as long as we now are living. Much of this food-related effects on human health, both positive and negative, has to be attributed to "epigenetic", not "mutagenic" mechanisms (Trosko 2006;Trosko, Chang, and Upham 2002;Trosko et al 1998).…”

Section: Global Bioethics As It Relates To "One Health One Planet"mentioning

confidence: 99%

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

Troskoa¹

2015

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With the cultural myth that science can only determine the way the world "is" (facts), while humanities, social sciences, lawyers, philosophers, and theologians must determine the way the world "ought to be" (values), those in position of global-, national-, and local-political power make major decisions of the use (or non-use) of scientific knowledge and technology. As a result, the human being has created a non-scientifically based cultural environment that is affecting his ability to survive. In effect, cultural evolution is occurring more rapidly than biological evolution that can adapt to the changes brought about in the physical and psycho-social environments. In a pluralistic cultural world, where each society has generated a different view of human nature and different ethical values, the use, misuse, or non-use of scientific and technological advances are derived from these unscientific views of human nature. Since all life depends on limiting interacting environmental and ecological factors, it is imperative that scientific information be used to govern how to minimize irreversible effects on life-sustaining ecological factors, but also scientific information bearing on understanding human nature ought to be integrated into a "global bioethics". While ethical values cannot be directly derived from scientific factors, it is also true that human values or our "ought" cannot be maintained in ignorance or defiance of the facts or the "is".

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Epigenetic toxicology as toxicant-induced changes in intracellular signalling leading to altered gap junctional intercellular communication

Cited by 107 publications

References 36 publications

Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids

Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids

Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility

Global Bioethical Prevention of the Collision of Biological and Cultural Evolution on Miserable Human Survival

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