Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

Vidoni, Chiara; Ferraresi, Alessandra; Secomandi, Eleonora; Vallino, Letizia; Dhanasekaran, Danny N.; Isidoro, Ciro

doi:10.1016/j.semcancer.2019.04.006

Cited by 35 publications

(24 citation statements)

References 126 publications

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“…In addition to pro-apoptotic mechanisms, TQ promotes cell death in cancer cells via autophagy. Autophagy is emerging as a double-edged sword in cancer biology [22,113,114]. In a context-specific manner, autophagy suppresses tumor growth in specific instances or promotes cancer cell growth and survival.…”

Section: Induction Of Autophagic Cell Death In Cancer Cells By Tqmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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Section: Induction Of Autophagic Cell Death In Cancer Cells By Tqmentioning

confidence: 99%

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Gomathinayagam

Jayaraman

et al. 2020

J Cancer Prev

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“…Autophagic response in cancer development is both tumor-suppressive and tumor promoting depending on such factors as cancer type, energy status and metabolic processes within a cell. Moreover, the regulation of autophagy by phytochemicals in cancer cells also depends on epigenetic mechanisms that modulate the expression of key proteins involved in its induction [87] . The overall chemopreventive effects of various phytochemicals [88] , including those discussed in the current review, were also attributed to their ability in regulating microRNA levels.…”

Section: Future Perspectives and Concluding Remarksmentioning

confidence: 99%

Role of autophagic response induced by major phytochemicals in cancer prevention and treatment

Wenner¹,

Stewart²,

McCabe³

et al. 2020

JCMT

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Phytochemicals derived from dietary sources and natural products have gained significant attention in the scientific community due to their ability to modulate various pharmacological and biological activities. Understanding the molecular mechanisms by which natural products protect against various diseases including cancer will provide the basis for both clinical use and further chemical modification to develop targeted therapy. Autophagy, an evolutionarily conserved self-digestion process that employs lysosomal-mediated enzymatic degradation has a functional role in a wide range of pathological disorders, and has attracted oncology scientists over the past two decades. Studies employing natural products have shown that induction of autophagy may be either cytoprotective or cytotoxic governed by different molecular pathways. In this review, we summarize four major phytochemicals namely phenethyl isothiocyanate, capsaicin, withaferin A, genistein and their association with autophagy in cancer chemoprevention. We also discuss ideas for further investigation essential to understanding their mechanisms, which will guide their clinical applications for cancer prevention and treatment.

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“…Various natural compounds, including polyphenols, have recently been known to exhibit anticancer effects via autophagy modulation [25][26][27][28]. For example, by controlling autophagy, plant flavonoid wogonin has been shown to cause cancer cell death [29] and curcumin can induce autophagy-and apoptosis-mediated cell death in chronic myeloid leukemia cells by lowering the B-cell lymphoma 2 (Bcl-2) protein [30].…”

Section: Introductionmentioning

confidence: 99%

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

Kiruthiga

Devi

Nabavi

et al. 2020

Cancers

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Autophagy is a conserved biological phenomenon that maintains cellular homeostasis through the clearing of damaged cellular components under cellular stress and offers the cell building blocks for cellular survival. Aberrations in autophagy subsidize to various human pathologies, such as dementia, cardiovascular diseases, leishmaniosis, influenza, hepatic diseases, and cancer, including hepatocellular carcinoma (HCC). HCC is the fifth common mortal type of liver cancer globally, with an inhomogeneous topographical distribution and highest incidence tripled in men than women. Existing treatment procedures with liver cancer patients result in variable success rates and poor prognosis due to their drug resistance and toxicity. One of the pathophysiological mechanisms that are targeted during the development of anti-liver cancer drugs is autophagy. Generally, overactivated autophagy may lead to a non-apoptotic form of programmed cell death (PCD) or autophagic cell death or type II PCD. Emerging evidence suggests that manipulation of autophagy could induce type II PCD in cancer cells, acting as a potential tumor suppressor. Hence, altering autophagic signaling offers new hope for the development of novel drugs for the therapy of resistant cancer cells. Natural polyphenolic compounds, including flavonoids and non-flavonoids, execute their anticarcinogenic mechanism through upregulating tumor suppressors and autophagy by modulating canonical (Beclin-1-dependent) and non-canonical (Beclin-1-independent) signaling pathways. Additionally, there is evidence signifying that plant polyphenols target angiogenesis and metastasis in HCC via interference with multiple intracellular signals and decrease the risk against HCC. The current review offers a comprehensive understanding of how natural polyphenolic compounds exhibit their anti-HCC effects through regulation of autophagy, the non-apoptotic mode of cell death.

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Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

Cited by 35 publications

References 126 publications

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Role of autophagic response induced by major phytochemicals in cancer prevention and treatment

Autophagy: A Potential Therapeutic Target of Polyphenols in Hepatocellular Carcinoma

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