Epigenetic targeting in lymphoma

Booth, Stephen; Collins, Graham P.

doi:10.1111/bjh.16914

Cited by 5 publications

(4 citation statements)

References 97 publications

(200 reference statements)

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“…These modifications mostly regulate the nucleosomal arrangement around DNA and control the gene activation or inactivation. The five prototypical examples to be discussed in this article include 1) DNA methylation, 2) Histone modifications, 3) Chromatin Remodeling 4) microRNAs and 5) long non-coding RNAs (67,68) [Figure 2, reviewed in Singh et al, 2020 (24)]. These different situations point to a unique aspect of genomic regulation in that external factors, outside the domain of DNA sequences, can regulate complex disease processes (69)(70)(71)(72).…”

Section: Epigenetics and Diabetic Vasculopathymentioning

confidence: 99%

Epigenetic basis of diabetic vasculopathy

et al. 2022

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Type 2 diabetes mellitus (T2DM) causes peripheral vascular disease because of which several blood-borne factors, including vital nutrients fail to reach the affected tissue. Tissue epigenome is sensitive to chronic hyperglycemia and is known to cause pathogenesis of micro- and macrovascular complications. These vascular complications of T2DM may perpetuate the onset of organ dysfunction. The burden of diabetes is primarily because of a wide range of complications of which nonhealing diabetic ulcers represent a major component. Thus, it is imperative that current research help recognize more effective methods for the diagnosis and management of early vascular injuries. This review addresses the significance of epigenetic processes such as DNA methylation and histone modifications in the evolution of macrovascular and microvascular complications of T2DM.

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Section: Epigenetics and Diabetic Vasculopathymentioning

confidence: 99%

Epigenetic basis of diabetic vasculopathy

et al. 2022

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“…These modifications mostly target the storage activation and inactivation of DNA. The three prototypical examples include (i) DNA methylation, (ii) histone modifications, and (iii) chromatin remodeling [ 25 ]. As outlined in Figures 4 and 5 , these modifications have the ability to change the ability of DNA to be transcribed [ 26 , 27 ].…”

Section: Applications Of Lcm To Epigenetic Studiesmentioning

confidence: 99%

“…Primary histone acetylation is done by acetyltransferases (HAT). On the other hand, deacetylation which is performed by histone deacetylases (HDAC) tightens the conformation of the nucleosome and limits transcription [ 25 ].…”

Section: Applications Of Lcm To Epigenetic Studiesmentioning

confidence: 99%

Laser Capture Microdissection in the Spatial Analysis of Epigenetic Modifications in Skin: A Comprehensive Review

Bhamidipati

Sinha

Sen

et al. 2022

Oxidative Medicine and Cellular Longevity

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Each cell in the body contains an intricate regulation for the expression of its relevant DNA. While every cell in a multicellular organism contains identical DNA, each tissue-specific cell expresses a different set of active genes. This organizational property exists in a paradigm that is largely controlled by forces external to the DNA sequence via epigenetic regulation. DNA methylation and chromatin modifications represent some of the classical epigenetic modifications that control gene expression. Complex tissues like skin consist of heterogeneous cell types that are spatially distributed and mixed. Furthermore, each individual skin cell has a unique response to physiological and pathological cues. As such, it is difficult to classify skin tissue as homogenous across all cell types and across different environmental exposures. Therefore, it would be prudent to isolate targeted tissue elements prior to any molecular analysis to avoid a possibility of confounding the sample with unwanted cell types. Laser capture microdissection (LCM) is a powerful technique used to isolate a targeted cell group with extreme microscopic precision. LCM presents itself as a solution to tackling the problem of tissue heterogeneity in molecular analysis. This review will cover an overview of LCM technology, the principals surrounding its application, and benefits of its application to the newly defined field of epigenomics, in particular of cutaneous pathology. This presents a comprehensive review about LCM and its use in the spatial analysis of skin epigenetics. Within the realm of skin pathology, this ability to isolate tissues under specific environmental stresses, such as oxidative stress, allows a far more focused investigation.

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“…Despite advancements in treatment, the prognosis of patients with relapsed or refractory lymphoma remains poor. Although targeted therapies have cured some patients, managing refractory and relapsed conditions remains challenging [ 193 ]. Notably, although targeted therapeutic strategies have led to curative outcomes in a subset of patients with lymphoma, managing refractory and relapsed disease persistently presents a substantial challenge [ 194 ].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways

Liu,

Che,

2024

Biomark Res

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Neddylation is a post-translational modification process, similar to ubiquitination, that controls several biological processes. Notably, it is often aberrantly activated in neoplasms and plays a critical role in the intricate dynamics of the tumor microenvironment (TME). This regulatory influence of neddylation permeates extensively and profoundly within the TME, affecting the behavior of tumor cells, immune cells, angiogenesis, and the extracellular matrix. Usually, neddylation promotes tumor progression towards increased malignancy. In this review, we highlight the latest understanding of the intricate molecular mechanisms that target neddylation to modulate the TME by affecting various signaling pathways. There is emerging evidence that the targeted disruption of the neddylation modification process, specifically the inhibition of cullin-RING ligases (CRLs) functionality, presents a promising avenue for targeted therapy. MLN4924, a small-molecule inhibitor of the neddylation pathway, precisely targets the neural precursor cell-expressed developmentally downregulated protein 8 activating enzyme (NAE). In recent years, significant advancements have been made in the field of neddylation modification therapy, particularly the integration of MLN4924 with chemotherapy or targeted therapy. This combined approach has demonstrated notable success in the treatment of a variety of hematological and solid tumors. Here, we investigated the inhibitory effects of MLN4924 on neddylation and summarized the current therapeutic outcomes of MLN4924 against various tumors. In conclusion, this review provides a comprehensive, up-to-date, and thorough overview of neddylation modifications, and offers insight into the critical importance of this cellular process in tumorigenesis.

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Epigenetic targeting in lymphoma

Cited by 5 publications

References 97 publications

Epigenetic basis of diabetic vasculopathy

Epigenetic basis of diabetic vasculopathy

Laser Capture Microdissection in the Spatial Analysis of Epigenetic Modifications in Skin: A Comprehensive Review

Deciphering the role of neddylation in tumor microenvironment modulation: common outcome of multiple signaling pathways

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