Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

Guo, Wenqian; Ma, Han; Wang, Chong‐Zhi; Wan, Jianwei; Yao, Haiqiang; Yuan, Chun‐Su

doi:10.3389/fphar.2021.790321

Cited by 8 publications

(4 citation statements)

References 92 publications

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“…Recent studies have found that the occurrence and development of inflammation are accompanied by abnormal changes in DNA methylation [1,2]. DNA methylation is the most common epigenetic modification and is mediated by DNA methyltransferases (DNMTs, including DNMT3a and DNMT3b) [3].…”

Section: Introductionmentioning

confidence: 99%

Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

2022

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Akebia saponin D (ASD) is derived from the Dipsacus asper Wall. ex Henry, which is a traditional Chinese medicine commonly used to treat rheumatic arthritis (RA). However, the in-depth mechanism of the anti-inflammatory effect of ASD is still unclear. This study aimed to preliminarily explore the anti-inflammatory effect of ASD and the underlying mechanisms from the perspective of DNA methylation and inflammation-related pathways. We found that ASD significantly reduced the production of multiple inflammatory mediators, including nitric oxide (NO) and prostaglandin E2 (PGE2), in LPS-induced RAW264.7 cells. The expression of DNA methyltransferase (DNMT) 3b and inducible nitric oxide synthase (iNOS) was also obviously inhibited by the ASD treatment. The protein and mRNA levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were also significantly inhibited by ASD. ASD inhibited the macrophage M1 phenotype, inhibited the high level of DNMT3b, and downregulated the signal transducer and activator of the transcription 3 (STAT3) pathway to exert its anti-inflammatory activity. Furthermore, DNMT3b siRNA and Nrf2 siRNA significantly promoted the anti-inflammatory effect of ASD. Our study demonstrates for the first time that ASD inhibits the IL-6-STAT3-DNMT3b axis and activates the nuclear factor-E2-related factor 2 (Nrf2) signaling pathway to achieve its inhibitory effect on inflammatory reactions.

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Section: Introductionmentioning

confidence: 99%

Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

2022

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“…Epigenetics are changes in gene expression without changes in DNA sequences and plays a role in cellular processes in various diseases (Ling and Ronn, 2019;Guo et al, 2021). Epigenetic changes can be caused by at least three mechanisms including DNA methylation, post-translational histone modifications, and regulation of gene expression by non-coding RNA (ncRNA) which can be microRNA (miRNA), long non-coding RNA (lncRNA), etc (Xiao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of botanical drugs in orchestrating epigenetic modifications for ameliorating metabolic disorders

Ariyanto

2024

Front. Pharmacol.

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“…It has been found that noncoding RNA regulates gene transcription by inducing DNA methylation and histone modifications [ 7 , 8 ]. DNA methylation and histone modifications are involved in many cellular processes and multiple human diseases [ 9 ]. Many substances can cause damage to the body by affecting the epigenetic state, resulting in the occurrence of chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic effects of herbal medicine

Lau

2023

Clin Epigenet

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Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic modification provides a potential link to gene expression changes that may be involved in the development of various chronic diseases, and targeting the epigenome becomes a plausible method for treating diseases. Traditional herbal medicine has gradually entered the vision of researchers due to its low toxicity and its effectiveness in treating diseases. As a matter of fact, researchers found that the possessed epigenetic modification capacity of herbal medicine had the ability to combat the progression of the disease, such as various types of cancer, diabetes, inflammation, amnesia, liver fibrosis, asthma, and hypertension-induced renal injury. Studies on the epigenetic effects of herbal medicine will provide valuable insights into the molecular mechanisms of human diseases, which may lead to new therapeutic approaches and diagnoses. Thus, this review summarized the impact of herbal medicine and its bioactive components on disease epigenome as examples of how utilization of epigenetic plasticity could be useful as the basis for the future development of targeted therapies in chronic diseases.

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Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

Cited by 8 publications

References 92 publications

Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway

The efficacy of botanical drugs in orchestrating epigenetic modifications for ameliorating metabolic disorders

Epigenetic effects of herbal medicine

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