Epigenetic state and gene expression remain stable after CRISPR/Cas-mediated chromosomal inversions
Solmaz Khosravi,
Rebecca Hinrichs,
Michelle Rönspies
et al.
Abstract:In Arabidopsis thaliana, the chromosome arms are DNA-hypomethylated and enriched in the euchromatin-specific histone mark H3K4me3. In contrast, pericentromeric regions are DNA-hypermethylated and enriched in H3K9me2. In order to investigate how chromosomal location affects epigenetic stability and gene activity, we induced two differently-sized inversions by CRISPR/Cas and introduced heterochromatic, pericentric sequences into an euchromatic chromosomal arm. The epigenetic status of the lines was investigated … Show more
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