Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma

Zhao, Jian; Wu, Guobin; Bu, Fanping; Lü, Bin; Liang, Anmin; Cao, Lei; Tong, Xin; Lü, Xin; Wu, Mengchao; Guo, Yajun

doi:10.1002/hep.23247

Cited by 96 publications

(81 citation statements)

References 36 publications

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“…Reports for other malignancies like leukemia, hepatocellular carcinoma, lung cancer and prostate cancer (Mori et al, 2004;Trigiante and Lu, 2006;Chen et al, 2010;Zhao et al, 2010;Zhang et al, 2011) also show altered expression of ASPP family proteins in both cell lines and tissue. These findings signify down regulation of ASPP1 and ASPP2 and overexpression of iASPP may contribute in tumorogenesis, disease progression and may have potent therapeutic application.…”

Section: Aspps: Task In Breast Cancermentioning

confidence: 96%

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Patel

Patel²,

Patel³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Aspps: Task In Breast Cancermentioning

confidence: 96%

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Patel

Patel²,

Patel³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The expression of ASPP2 and ASSP1 genes is frequently down-regulated by DNA methylation via increased DNMT expression in HBV-positive HCC, which may play important role in the development of HCC. (Samuels-Lev et al, 2001;Zhao et al, 2010).…”

Section: Effects Of Hbx Protein On Epigenetic Modificationsmentioning

confidence: 99%

Hepatitis B virus-induced hepatocellular carcinoma: The role of the virus x protein

Motavaf¹,

Safari²,

Jourshari³

et al. 2013

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Summary. -Hepatocellular carcinoma (HCC) is one of the most common malignant diseases and has the fourth highest mortality rate worldwide. Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in HCC. Currently available evidence support a critical role of hepatitis B virus x (HBx) gene and protein in the pathogenesis of HBV-induced HCC. HBx protein is a multifunctional regulator that modulates cellular signal transduction pathways, transcriptional regulations, cell cycle progress, DNA repair, apoptosis, and genetic stability by interacting with different host factors. This review describes the current state of knowledge about the biological roles of this protein in the development of HCC. Abbreviations: DNMTs = DNA methyltransferases; HBV = hepatitis B virus; HBx = hepatitis B x protein; HCC = hepatocellular carcinoma; MMP = matrix metalloproteinase; MTA = metastasisassociated protein; RAR-β2 = retinoic acid receptor β2; TSGs = tumor suppressor genes; XPB = xeroderma pigmentosum B

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“…The level of ASPP1 is downregulated and that of the iASPP is upregulated in leukemia cell lines and acute leukemia tissues (12,13). The expression of ASPP1 and ASPP2 was diminished in seven hepatocellular carcinoma cell lines (14).…”

Section: Introductionmentioning

confidence: 98%

Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP

Guangxia

Yuan

et al. 2012

Oncol Rep

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Abstract. The p53 protein is one of the best-known tumor suppressors. Recently discovered ASPP1 and ASPP2 are specific activators and iASPP is an inhibitor of p53. In the present study, we found that of 37 NSCLC patients, p53 alterations were detected in 20 tumors (54.1%), the mRNA expression of ASPP1 and ASPP2 was frequently dowregulated in tumor tissues, and this decreased significantly in samples expressing wild-type p53. The expression of ASPP1 and ASPP2 was downregulated and that of iASPP was upregulated in two NSCLC cell lines (the NCI-H157 cell line with altered p53 and the A549 cell line with wild-type p53). The NCI-H157 cell with higher ASPP1 and ASPP2 levels was more sensitive to cisplatin than the A549 cells with lower ASPP1 and ASPP2 levels. Downregulation of iASPP by siRNA stimulated apoptosis through p53 in two NSCLC cell lines. These findings provide new insights into the molecular mechanisms of action of the ASPP family in NSCLC and may have potent therapeutic applications.

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Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma

Abstract: The ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family of proteins regulates apoptosis through interaction with p53 and its family members. This study evaluated the epigenetic regulation of ASPP1 and ASPP2

Cited by 96 publications

References 36 publications

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Hepatitis B virus-induced hepatocellular carcinoma: The role of the virus x protein

Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP

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