Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness: Preliminary Findings from an Urban Community-Based Sample

Uddin, Monica; Galea, Sandro; Chang, Shun Chiao; Koenen, Karestan C.; Goldmann, Emily; Wildman, Derek E.; Aiello, Allison E.

doi:10.1080/19485565.2013.774627

Cited by 34 publications

(28 citation statements)

References 74 publications

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“…Some of the current human EWAS that have examined mDNA alterations in PTSD are summarized in Table 2. EWAS are listed in chronological order (2010–2017) [54•, 55, 56, 57•, 58, 59•, 60, 61]. The sites with differential mDNA together with the nearest gene are reported.…”

Section: Large-scale Genetic and Epigenetic Discovery Studiesmentioning

confidence: 99%

“…For example, the EWAS with the largest sample size to date identified epigenetic changes related to synapic plasticity, cholinergic signaling, oxytocin signaling, and inflammatory responses [61]. Smaller studies have implicated immune and inflammatory responses [54•, 55, 59•, 60], endocrine [60] and nervous system [56, 59, 60] pathways. One study has observed differential mDNA profiles in PTSD subjects with and without childhood abuse history [57•].…”

Section: Large-scale Genetic and Epigenetic Discovery Studiesmentioning

confidence: 99%

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Recent Genetics and Epigenetics Approaches to PTSD

Daskalakis

Rijal

King

et al. 2018

Curr Psychiatry Rep

100

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A substantial portion of the variance explaining differential risk responses to trauma exposure may be explained by differential inherited and acquired genetic and epigenetic risk. This biological risk is complemented by alterations in the functional regulation of genes via environmentally induced epigenetic changes, including prior childhood and adult trauma exposure. This review will cover recent findings from large-scale genome-wide association studies as well as newer epigenome-wide studies. We will also discuss future "phenome-wide" studies utilizing electronic medical records as well as targeted genetic studies focusing on mechanistic ways in which specific genetic or epigenetic alterations regulate the biological risk for PTSD.

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Section: Large-scale Genetic and Epigenetic Discovery Studiesmentioning

confidence: 99%

Section: Large-scale Genetic and Epigenetic Discovery Studiesmentioning

confidence: 99%

Recent Genetics and Epigenetics Approaches to PTSD

Daskalakis

Rijal

King

et al. 2018

Curr Psychiatry Rep

100

View full text Add to dashboard Cite

show abstract

“…Modeling the effects of early life stressors in animals has largely corroborated such results; exposure to maternal separation or neglect heightens stress reactivity, aggression, and other features of clinical disorders such as depression and schizophrenia [5–8]. Accumulating evidence not only suggests that early life environment affects relevant genes via epigenetic modifications which may serve as biomarkers for susceptible populations [9, 10], but furthermore that environmentally-induced behavioral deficits may be transmitted to subsequent generations [11–13]. Determining the relative contribution of genes versus environment to the manifestation of a specific behavior is of critical importance for not only elucidating its etiology, but also guiding ongoing endeavors to identify relevant trait-specific biomarkers.…”

Section: Introductionmentioning

confidence: 99%

The impact of maternal neglect on genetic hyperactivity

Majdak

Grogan

Gogola

et al. 2016

Behavioural Brain Research

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Early environmental conditions are increasingly appreciated as critical in shaping behavior and cognition. Evidence suggests that stressful rearing environments can have an enduring impact on behaviors in adulthood, but few studies have explored the possibility that rearing environment could exacerbate genetic hyperactivity disorders. Uncovering a strong environmental influence on the transmission of hyperactivity could provide novel avenues for translational research. Recently we developed a selectively bred High-Active line of mice to model ADHD, providing a unique resource to address the question of environmental transmission. The High-Active line demonstrates transgenerational hyperactivity, but the influence of the postnatal environment (i.e. maternal care provided by dams) on hyperactivity had not been systemically quantified. This study employed a cross-fostering method to simultaneously address 1) whether High-Active and Control pups are provided with similar levels of care in the early environment, and 2) whether any differences in rearing environment influence hyperactive behavior. High-Active dams demonstrated impairment in all measures of maternal competence relative to Controls, which reduced survival rates and significantly reduced the body mass of offspring in early life and at weaning. While the deteriorated postnatal environment provided by High-Active dams was ultimately sufficient to depress Control activity, the hyperactivity of High-Active offspring remained unaffected by fostering condition. These data not only confirm the power of genetics to influence hyperactivity across generations, but also provide evidence that early rearing environments may not have a significant impact on the extreme end of hyperactive phenotypes.

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“…Summary of 43 human-based epigenetic studies of PTSD published as of July 2017, enumerated and categorized according to relevant biological system or Epigenome-wide association (EWAS) approach: Hypothalamic-Pituitary Adrenal (HPA) Axis 105,108,116,119,139–150 ; EWAS 91–96,151–155 ; Age-related CpGs 129,132,133 ; Serotonergic system 156,157 ; Neurotrophin 117,158 ; Dopaminergic System 159 ; Catecholaminergic system 102 ; DNA methylation machinery 160 ; Estrogen-responsive genes 114 ; Immune Function 161 ; Other 162–165 .…”

Section: Figurementioning

confidence: 99%

Neuroepigenetics of Post-Traumatic Stress Disorder

Kim

Smith

Nievergelt

et al. 2018

Progress in Molecular Biology and Translational Science

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While diagnosis of PTSD is based on behavioral symptom clusters that are most directly associated with brain function, epigenetic studies of PTSD in humans to date have been limited to peripheral tissues. Animal models of PTSD have been key for understanding the epigenetic alterations in the brain most directly relevant to endophenotypes of PTSD, in particular those pertaining to fear memory and stress response. This chapter provides an overview of neuroepigenetic studies based on animal models of PTSD, with an emphasis on the effect of stress on fear memory. Where relevant, we also describe human-based studies with relevance to neuroepigenetic insights gleaned from animal work and suggest promising directions for future studies of PTSD neuroepigenetics in living humans that combine peripheral epigenetic measures with measures of central nervous system activity, structure and function.

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Epigenetic Signatures May Explain the Relationship between Socioeconomic Position and Risk of Mental Illness: Preliminary Findings from an Urban Community-Based Sample

Cited by 34 publications

References 74 publications

Recent Genetics and Epigenetics Approaches to PTSD

Recent Genetics and Epigenetics Approaches to PTSD

The impact of maternal neglect on genetic hyperactivity

Neuroepigenetics of Post-Traumatic Stress Disorder

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