Epigenetic signature in neural plasticity: the journey so far and journey ahead

Nayak, Madhusmita; Das, Diptimayee; Pradhan, Jyotsnamayee; Ahmed, R.G.; Laureano‐Melo, Roberto; Dandapat, Jagneshwar

doi:10.1016/j.heliyon.2022.e12292

Cited by 11 publications

(7 citation statements)

References 153 publications

(160 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our work has several implications for the understanding of the neural mechanism underlying substance abuse and potential therapeutic interventions. First, changes in cellular redox metabolism have been linked to gene activation and long term changes involving epigenetic mechanisms that affect neuronal plasticity [ 46 , 47 ]. Second, cellular metabolism is easily modulated by our lifestyle and food intake.…”

Section: Discussionmentioning

confidence: 99%

Influence of Redox and Dopamine Regulation in Cocaine-Induced Phenotypes Using Drosophila

et al. 2023

View full text Add to dashboard Cite

Reactive Oxidative Species (ROS) are produced during cellular metabolism and their amount is finely regulated because of negative consequences that ROS accumulation has on cellular functioning and survival. However, ROS play an important role in maintaining a healthy brain by participating in cellular signaling and regulating neuronal plasticity, which led to a shift in our understanding of ROS from being solely detrimental to having a more complex role in the brain. Here we use Drosophila melanogaster to investigate the influence of ROS on behavioral phenotypes induced by single or double exposure to volatilized cocaine (vCOC), sensitivity and locomotor sensitization (LS). Sensitivity and LS depend on glutathione antioxidant defense. Catalase activity and hydrogen peroxide (H2O2) accumulation play a minor role, but their presence is necessary in dopaminergic and serotonergic neurons for LS. Feeding flies the antioxidant quercetin completely abolishes LS confirming the permissive role of H2O2 in the development of LS. This can only partially be rescued by co-feeding H2O2 or the dopamine precursor 3,4-dihydroxy-L-phenylalanine (L-DA) showing coordinate and similar contribution of dopamine and H2O2. Genetic versatility of Drosophila can be used as a tool for more precise dissection of temporal, spatial and transcriptional events that regulate behaviors induced by vCOC.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Redox and Dopamine Regulation in Cocaine-Induced Phenotypes Using Drosophila

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Neural plasticity enables neurons to reshape their architecture in response to both internal and external stimuli, through DNA methylation/demethylation and histone acetylation/deacetylation, which have been extensively reviewed by Nayak et al . [ 88 ].…”

Section: Epigenetics and Aesthetic Experiences: A Focus On Music And ...mentioning

confidence: 99%

Wonder symphony: epigenetics and the enchantment of the arts

Gallazzi,

Pizzolante,

Biganzoli

et al. 2024

Environmental Epigenetics

View full text Add to dashboard Cite

Epigenetics, the study of heritable changes in gene expression without altering DNA sequence, has gained significant attention due to its implications for gene regulation and chromatin stability. Epigenetic mechanisms play a fundamental role in gene-environment interactions, shaping individual development and adaptation. DNA methylation, histone modifications, and non-coding RNAs are key epigenetic regulators. Epigenetic changes can be triggered by environmental factors, including stress, toxins, and social interactions, influencing health and well-being. Positive experiences, such as engagement with the arts, have been linked to emotional responses and neurotransmitter release. While the impacts of detrimental factors on epigenetics have been widely studied, the effects of positive influences are less explored. Specifically, visual art and music have profound effects on emotions, cognition, and mood regulation. Arts exposure enhances memory, reduces stress, and fosters social inclusion. Recent research has begun to explore the links between positive experiences and epigenetic modifications, suggesting that aesthetic experiences, including visual art and music fruition, might induce dynamic and/or stable changes in gene expression profiles. However, this field is in its infancy, and more research is needed to establish clear connections. Collaborative efforts among genetics, epigenetics, neuroscience, psychology, and the arts are essential for a comprehensive understanding. Longitudinal studies tracking sustained exposure to positive experiences and examining the influence of childhood artistic education on the biological bases of therapeutic effects of art and music are promising avenues for future research. Ultimately, understanding how positive experiences influence epigenetics could provide insights into long-term enhancing of human well-being.

show abstract

“…Brain-derived neurotrophic factor (BDNF) is a member of the most abundant neurotrophins family in the mammalian brain, contributing to the differentiation of neuronal populations in the central and peripheral nervous systems and synaptic plasticity during development and in adult life [71,72]. BDNF expression is controlled by the BDNF gene found at locus 11p14.1 [73], contributing to numerous cognitive functions, including those related to learning and long-term visual memory [74].…”

Section: Val66met (Rs6265) Of Bdnfmentioning

confidence: 99%

Risk Polymorphisms of FNDC5, BDNF, and NTRK2 and Poor Education Interact and Aggravate Age-Related Cognitive Decline

Tomás,

Bento-Torres,

Jardim

et al. 2023

IJMS

View full text Add to dashboard Cite

Cognitive abilities tend to decline with aging, with variation between individuals, and many studies seek to identify genetic biomarkers that more accurately anticipate risks related to pathological aging. We investigated the influence of BDNF, NTRK2, and FNDC5 single nucleotide polymorphisms (SNPs) on the cognitive performance of young and older adults with contrasting educational backgrounds. We addressed three questions: (1) Is education associated with reduced age-related cognitive decline? (2) Does the presence of SNPs explain the variation in cognitive performance observed late in life? (3) Is education differentially associated with cognition based on the presence of BDNF, NTRK2, or FNDC5 polymorphisms? We measured the cognitive functions of young and older participants, with lower and higher education, using specific and sensitive tests of the Cambridge Automated Neuropsychological Test Assessment Battery. A three-way ANOVA revealed that SNPs were associated with differential performances in executive functions, episodic memory, sustained attention, mental and motor response speed, and visual recognition memory and that higher educational levels improved the affected cognitive functions. The results revealed that distinct SNPs affect cognition late in life differentially, suggesting their utility as potential biomarkers and emphasizing the importance of cognitive stimulation that advanced education early in life provides.

show abstract

Epigenetic signature in neural plasticity: the journey so far and journey ahead

Cited by 11 publications

References 153 publications

Influence of Redox and Dopamine Regulation in Cocaine-Induced Phenotypes Using Drosophila

Influence of Redox and Dopamine Regulation in Cocaine-Induced Phenotypes Using Drosophila

Wonder symphony: epigenetics and the enchantment of the arts

Risk Polymorphisms of FNDC5, BDNF, and NTRK2 and Poor Education Interact and Aggravate Age-Related Cognitive Decline

Contact Info

Product

Resources

About