Epigenetic responses to stress: triple defense?

Gutzat, Ruben; Scheid, Ortrun Mittelsten

doi:10.1016/j.pbi.2012.08.007

Cited by 114 publications

(86 citation statements)

References 63 publications

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“…Changes in DNA methylation, several posttranslational histone modifications, as well as a linker histone H1 variant have been implicated in plant responses to osmotic/salt stress (2,3,6,10,20,21,(42)(43)(44)(45), but in most cases the relationship among chromatin status, transcriptional responsiveness, and physiological outcomes is not clearly understood. Interestingly, in both metazoans and plants, histone phosphorylation appears to be involved in responses to osmotic/salt stress (3,17,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…epigenetics | heterochromatin | histone phosphorylation | abiotic stress | protein kinase P lants, due to their sessile nature, adopt special strategies to cope with adverse environmental conditions, resulting in complex interactions among signaling pathways and developmental programs that impinge on chromatin organization and transcriptional activity (1)(2)(3). A growing body of evidence indicates that changes in DNA methylation and certain posttranslational histone modifications are involved in plant responses to environmental stresses, possibly by modulating the expression of stress responsive genes and/or chromosomal structures (1-6).…”

mentioning

confidence: 99%

“…A growing body of evidence indicates that changes in DNA methylation and certain posttranslational histone modifications are involved in plant responses to environmental stresses, possibly by modulating the expression of stress responsive genes and/or chromosomal structures (1-6). Environmental cues, especially high temperature, can also transiently influence gene expression or heterochromatin organization via changes in histone variants and/or nucleosome occupancy, without obvious alterations in well-characterized epigenetic marks (2,3,(7)(8)(9)(10).…”

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confidence: 99%

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Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana

Wang

Casas-Mollano

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

132

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Histone phosphorylation plays key roles in stress-induced transcriptional reprogramming in metazoans but its function(s) in land plants has remained relatively unexplored. Here we report that an Arabidopsis mutant defective in At3g03940 and At5g18190, encoding closely related Ser/Thr protein kinases, shows pleiotropic phenotypes including dwarfism and hypersensitivity to osmotic/salt stress. The double mutant has reduced global levels of phosphorylated histone H3 threonine 3 (H3T3ph), which are not enhanced, unlike the response in the wild type, by drought-like treatments. Genome-wide analyses revealed increased H3T3ph, slight enhancement in trimethylated histone H3 lysine 4 (H3K4me3), and a modest decrease in histone H3 occupancy in pericentromeric/knob regions of wild-type plants under osmotic stress. However, despite these changes in heterochromatin, transposons and repeats remained transcriptionally repressed. In contrast, this reorganization of heterochromatin was mostly absent in the double mutant, which exhibited lower H3T3ph levels in pericentromeric regions even under normal environmental conditions. Interestingly, within actively transcribed protein-coding genes, H3T3ph density was minimal in 5′ genic regions, coincidental with a peak of H3K4me3 accumulation. This pattern was not affected in the double mutant, implying the existence of additional H3T3 protein kinases in Arabidopsis. Our results suggest that At3g03940 and At5g18190 are involved in the phosphorylation of H3T3 in pericentromeric/knob regions and that this repressive epigenetic mark may be important for maintaining proper heterochromatic organization and, possibly, chromosome function(s).epigenetics | heterochromatin | histone phosphorylation | abiotic stress | protein kinase

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana

Wang

Casas-Mollano

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

132

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“…Environmental challenges such as stress can lead to alterations in gene expression by changes in chromatin structure at responsive genes and/or the biogenesis of small RNAs (for review, see Gutzat and Mittelsten Scheid 2012). For instance, it was shown that abiotic stress can cause the release of transgene silencing and the reactivation of endogenous heterochromatic loci in Arabidopsis (Lang-Mladek et al 2010;Pecinka et al 2010;TittelElmer et al 2010).…”

Section: Epigenetic Stress Responses and Their Potential Inheritancementioning

confidence: 99%

“…Numerous reports supposedly show that stressinduced epigenetic variation can be inherited during several generations (for review, see Boyko and Kovalchuk 2011;Gutzat and Mittelsten Scheid 2012). In stressed Nicotiana tabacum and Arabidopsis plants, as well as in their unstressed progeny, homologous recombination occurs at a higher frequency than in control plants (Molinier et al 2006;Boyko et al 2007Boyko et al , 2010Kathiria et al 2010).…”

Section: Epigenetic Stress Responses and Their Potential Inheritancementioning

confidence: 99%

Epigenetic Variation, Inheritance, and Selection in Plant Populations

Hirsch

Baumberger

Grossniklaus

2012

Cold Spring Harbor Symposia on Quantitative Biology

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Plant populations show phenotypic diversity, which may be caused by genetic and epigenetic variation. It has recently been shown that new epigenetic variants are generated at a higher rate than genetic variants and several studies have shown that epigenetic variation can be influenced by the environment. Although the heritability of environmentally induced epigenetic traits has gained increasing interest in past years, it is still not clear whether and to what extent induced epigenetic changes have a role in ecology and evolution. Some reports on model and nonmodel species support the possibility of adaptive epigenetic alleles, indicating that epigenetic variants are subject to natural selection. However, most of these studies rely solely on phenotypic data and no information is available about the underlying mechanisms. Thus, the role of inherited epigenetic variation for plant adaptation is unclear and further investigations are required to gain insights into the significance of epigenetic variation for ecological and evolutionary processes. Here, we review mechanisms of epigenetic regulation, epigenetic responses to environmental challenges, their inheritance, and their implication for adaptation and plant evolution.

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Transcription factor ABI3 auto‐activates its own expression during dehydration stress response

Bedi

Chaudhuri

2018

FEBS Letters

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The transcription factor abscisic acid insensitive 3 (ABI3) has recently been shown to mediate the dehydration stress response in nonseed and seed plants by regulation of several downstream genes. Here, we show how ABI3 autoregulates its transcription in response to dehydration stress signalling. Autoactivation is primarily through the Sph/RY element CATGCA present at the promoter region of ABI3. Along with other known cis-elements found at the ABI3 promoter, CATGCA remains occluded by nucleosomes during transcription repression. The nucleosomes tend to reposit during active transcription and are associated with several histone modifications, such as H3K9 and K27 acetylations and H3K4 trimethylation. This work thus, reveals the genetic and epigenetic essentials required for expression of the ABI3 gene, a crucial factor regulating dehydration stress signalling in Arabidopsis thaliana.

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Epigenetic responses to stress: triple defense?

Cited by 114 publications

References 63 publications

Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana

Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana

Epigenetic Variation, Inheritance, and Selection in Plant Populations

Transcription factor ABI3 auto‐activates its own expression during dehydration stress response

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