Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer

Shen, Ruinan; Shen, Pan; Qi, Sheng-jian; Lin, Xiaolin; Cheng, Sheng

doi:10.1016/j.bbrc.2010.03.121

Cited by 140 publications

(104 citation statements)

References 19 publications

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“…SOX4 is a member of the SRYrelated HMG-box (SOX) family of transcription factors involved in cell apoptosis as well as tumorigenesis. SOX4 is up-regulated in GC compared to benign gastric tissues, which may be attributed to the hypermethylation of miR-129 (Shen et al, 2010). PLAG1 is a zinc-finger protein with 2 putative nuclear localization signals.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer

Wang¹,

Wu²,

Wang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. To identify potential targets for the early treatment and prevention of gastric cancer, microRNA (miRNA) expression profiles of precancerous lesions of gastric cancer were investigated. The miRNA microarray dataset GSE24839 was downloaded from Gene Expression Omnibus (GEO) and included 10 Helicobacter pylori-related gastritis samples and 10 gastric intestinal metaplasia samples. Differentially expressed miRNAs (DEMs) were screened using the Student t-test; P < 0.05 was considered to be statistically significant. Co-expression networks of total miRNAs and DEMs were constructed based on the Pearson correlation coefficient for the two diseases. Target genes of the DEMs were retrieved using miRecords and pathway-enrichment analysis was performed using a hypergeometric test. A total of 20 DEMs were obtained for H. pylori-related gastritis and gastric intestinal metaplasia samples, including 12 up-regulated and 8 down-regulated miRNAs. The identified DEMs appear to play key roles in gastric cancer, as the average degree of the DEM sub-network was higher than that of the total miRNA co-expression network. Furthermore, target genes for 6 DEMs (hsa-miR-106b, hsa-miR-193a-3p, hsa-miR-204, hsa-miR-30e, hsa-miR-519d, and hsa-miR-524-5p) are in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including signal transduction, cell growth and death, and transport and catabolism. Among the target genes, 5 (RAB22A, SOX4, IKZF2, PLAG1, and BTBD7) were of interest because they can be simultaneously regulated by several DEMs. These findings suggest that these genes may be targets for modulating gastric cancer progression.

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Section: Discussionmentioning

confidence: 99%

MicroRNA network analysis identifies key microRNAs and genes associated with precancerous lesions of gastric cancer

Wang¹,

Wu²,

Wang³

et al. 2014

Genet. Mol. Res.

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show abstract

“…The dysregulated miRNAs and their confirmed targets are listed in Supplementary Table 1 (Volinia et al, 2006;Zhang et al, 2007aZhang et al, , 2008Zhang et al, , 2009Zhang et al, , 2010Kim do et al, 2007;Chan et al, 2008;Choy et al, 2008;Petrocca et al, 2008;Ando et al, 2009;Bandres et al, 2009;Du et al, 2009;Guo et al, 2009;Katada et al, 2009;Kim et al, 2009;Liu et al, 2009;Saito et al, 2009;Takagi et al, 2009;Chen et al, 2010;Fassi Fehri et al, 2010;Gao et al, 2010;Hashimoto et al, 2010;Jiang et al, 2010;Lai et al, 2010;Matsushima et al, 2010;Motoyama et al, 2008Motoyama et al, , 2010Shen et al, 2010;Shinozaki et al, 2010;Tsujiura et al, 2010;Tsukamoto et al, 2010;Ueda et al, 2010;Wan et al, 2010;Wu et al, 2010a;Xia et al, 2008;Xiao et al, 2009;Zhu et al, 2010).…”

Section: Dysregulated Mirnas In Gastric Cancermentioning

confidence: 99%

MicroRNA dysregulation in gastric cancer: a new player enters the game

et al. 2010

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“…Recent studies have indicated that several miRNAs, including miR-34b/c, miR-129, miR-137, miR-181C, miR-199a, miR-212, miR-512 and miR-516, were dysregulated and showed aberrant methylation patterns in gastric cancer cells. 6,9,[14][15][16][17][18][19][20][21] The three pri-miR-9 transcripts are all located within non-protein coding transcripts (Fig. 2A).…”

Section: Cell Lines and 5-aza-dc Treatmentmentioning

confidence: 99%

“…[2][3][4] Previous studies have shown that many miRNAs are aberrantly overexpressed or downregulated during gastric cancer progression, including miR- 16, miR-21, miR-101, miR-126, miR-129, miR-181c, miR-196b and -200. [5][6][7][8][9][10][11][12] These miRNAs could play oncogenic or tumor-suppressive functions in the regulation of cell growth, apoptosis and cell migration by repressing their target genes.…”

Section: Introductionmentioning

confidence: 99%