Epigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity
Jumee Kim,
Eun-Ji Kwon,
Yun-Jeong Kim
et al.
Abstract:During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death, known as “culture adaptation.” This adaptation is associated with genetic and epigenetic abnormalities, including TP53 mutations, copy number variations, trisomy, and methylation changes. Understanding the molecular mechanisms underlying this acquired survival advantage is crucial for safe hPSC-based cell therapies. Through transcriptome and meth… Show more
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