2017
DOI: 10.1007/s00018-017-2684-9
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Abstract: The hypoxia-inducible factor (HIF) is a heterodimeric transcription factor governing a transcriptional program in response to reduced O2 availability in metazoans. It contributes to physiology and pathogenesis of many human diseases through its downstream target genes. Emerging studies have shown that the transcriptional activity of HIF is highly regulated at multiple levels and the epigenetic regulators are essential for HIF-mediated transactivation. In this review, we will discuss the comprehensive regulatio… Show more

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Cited by 47 publications
(38 citation statements)
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“…The histone acetyltransferases p300, CBP, and TIP60 induce acetylation of histones H3 and H4 to increase transcription of a subset of HIF-1 target genes (27,28). HDACs 1-7 are also known to enhance or suppress HIF-1 transcriptional activity via the different mechanisms (26). We have demonstrated that JMJD2C demethylates trimethyl lysine 9 of histone H3 at the HREs to increase HIF-1-mediated transactivation in human cancer cells (7).…”
Section: Zmynd8 Acetylation Mediates Hif-dependent Breast Cancer Progmentioning
confidence: 84%
See 1 more Smart Citation
“…The histone acetyltransferases p300, CBP, and TIP60 induce acetylation of histones H3 and H4 to increase transcription of a subset of HIF-1 target genes (27,28). HDACs 1-7 are also known to enhance or suppress HIF-1 transcriptional activity via the different mechanisms (26). We have demonstrated that JMJD2C demethylates trimethyl lysine 9 of histone H3 at the HREs to increase HIF-1-mediated transactivation in human cancer cells (7).…”
Section: Zmynd8 Acetylation Mediates Hif-dependent Breast Cancer Progmentioning
confidence: 84%
“…Epigenetic regulators are essential for HIF-mediated transactivation (26). The histone acetyltransferases p300, CBP, and TIP60 induce acetylation of histones H3 and H4 to increase transcription of a subset of HIF-1 target genes (27,28).…”
Section: Zmynd8 Acetylation Mediates Hif-dependent Breast Cancer Progmentioning
confidence: 99%
“…Strikingly, loss of KDM5A, whose activity opposes that of KMT2D at H3K4 sites, caused upregulation of hypoxia-responsive genes (37), i.e., an effect opposite to the present KS1-associated suppression of hypoxia response genes, such as Klf10 and Bcl2/adenovirus E1B 19-KD protein-interacting protein 3-like (Bnip3l). Several histone demethylases, and at least 33 chromatin modifiers in total, have been shown to affect hypoxia response genes, 11 of these associating with developmental disorders or cancers, yet KMT2D and other histone methyltransferases have not yet been implicated (38).…”
Section: Discussionmentioning
confidence: 99%
“…Firstly, as non‐syncitialized BeWo cells primarily consist of cytotrophoblast that most appropriately model early gestation, extrapolation of these data from this preliminary study to the whole gestational stage is difficult and more experimental models (ie, syncytializing and/or syncytialized trophoblast cells, primary placental cells, animal models, etc) will definitely be needed to validate our results. Additionally, apart from suppression of placental BCRP, HDAC1 inhibition could result in potential effect on other placental and non‐placental targets, which might have major phenotypic implications. Therefore, more studies should be further undertaken to verify the safety of HDAC1 inhibition, particularly for foetal development.…”
Section: Discussionmentioning
confidence: 99%