Epigenetic Regulator CoREST Controls Social Behavior in Ants

Glastad, Karl M.; Graham, Riley; Ju, Linyang; Roessler, Julian; Brady, Cristina M.; Berger, Shelley L.

doi:10.1016/j.molcel.2019.10.012

Cited by 40 publications

(78 citation statements)

References 62 publications

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“…However, the intrinsic epigenetic mechanisms at play in the reprogramming of Majors and Minors have remained largely elusive. Here, Glastad et al (2019) uncover an epigenetic switch underlying caste fate and demonstrate an important function for the CoREST corepressor in the induced reprogramming of transcriptional networks in Major worker ants that lead to a Minor-like foraging behavior.…”

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confidence: 89%

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Ant-icipating Change: An Epigenetic Switch in Reprogramming the Social Lives of Ants

Pray-Grant

Grant

2020

Molecular Cell

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confidence: 89%

“…

Glastad et al (2019) describe a role for the neuronal CoREST corepressor and changes in juvenile hormone (JH) and ecdysone signaling during the reprogramming of social behavioral phenotypes in ants that are reflective of a natural mechanism differentiating ''Major'' and ''Minor'' worker ants.

…”

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confidence: 99%

Ant-icipating Change: An Epigenetic Switch in Reprogramming the Social Lives of Ants

Pray-Grant

Grant

2020

Molecular Cell

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“…Majors can be reprogrammed to foraging via administration of histone deacetylase inhibitors (HDACi's) (Table 1), shifting behavioral phenotypes towards the minor form as acetylation levels are increased [88]. Corepressor for element-1-silencing transcription factor (CoREST) also experiences upregulation when HDACi is administered, and subsequently promotes JH synthesis by repressing JH-degrading enzyme production [89]. These findings imply the involvement of CoREST and acetylation in the development of these two distinct castes, though there has not yet been a study to validate this possibility.…”

Section: Figurementioning

confidence: 99%

(Epi)Genetic Mechanisms Underlying the Evolutionary Success of Eusocial Insects

Sieber

Dorman

Newell

et al. 2021

Insects

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Eusocial insects, such as bees, ants, and wasps of the Hymenoptera and termites of the Blattodea, are able to generate remarkable diversity in morphology and behavior despite being genetically uniform within a colony. Most eusocial insect species display caste structures in which reproductive ability is possessed by a single or a few queens while all other colony members act as workers. However, in some species, caste structure is somewhat plastic, and individuals may switch from one caste or behavioral phenotype to another in response to certain environmental cues. As different castes normally share a common genetic background, it is believed that much of this observed within-colony diversity results from transcriptional differences between individuals. This suggests that epigenetic mechanisms, featured by modified gene expression without changing genes themselves, may play an important role in eusocial insects. Indeed, epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNAs, have been shown to influence eusocial insects in multiple aspects, along with typical genetic regulation. This review summarizes the most recent findings regarding such mechanisms and their diverse roles in eusocial insects.

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“…The copyright holder for this this version posted December 10, 2020. ; https://doi.org/10.1101/2020.12.08.407056 doi: bioRxiv preprint 9 workers and after caste reprogramming 42 , which could be involved in caste memory formation 43 . There are also other genes of interest, which to our knowledge have not previously associated with caste, including Toll-like receptor 8 (OG0002639) (see Supplementary Table S6).…”

Section: Analyses Of Orthologous Genes Found In All Nine Species (Supmentioning

confidence: 99%

Genetic toolkit for sociality predicts castes across the spectrum of social complexity in wasps

Wyatt

Bentley

Taylor

et al. 2020

Preprint

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Major evolutionary transitions describe how biological complexity arises; e.g. in evolution of complex multicellular bodies, and superorganismal insect societies. Such transitions involve the evolution of division of labour, e.g. as queen and worker castes in insect societies. Castes across different evolutionary lineages are thought to be regulated by a conserved genetic toolkit. However, this hypothesis has not been tested thoroughly across the complexity spectrum of the major transition. Here we reveal, using machine learning analyses of brain transcription, evidence of a shared genetic toolkit across the spectrum of social complexity in Vespid wasps. Whilst molecular processes underpinning the simpler societies (which likely represent the origins of social living) are conserved throughout the major transition, additional processes appear to come into play in more complex societies. Such fundamental shifts in regulatory processes with complexity may typify other major evolutionary transitions, such as the evolution of multicellularity.

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Epigenetic Regulator CoREST Controls Social Behavior in Ants

Abstract: Highlights d Reprogrammed worker ant behavior mirrors natural programming via an epigenetic switch d Neuronal co-repressor CoREST mediates this behavioral programming and reprogramming d CoREST controls genes that then govern levels of foragingpromoting JH

Cited by 40 publications

References 62 publications

Ant-icipating Change: An Epigenetic Switch in Reprogramming the Social Lives of Ants

Ant-icipating Change: An Epigenetic Switch in Reprogramming the Social Lives of Ants

(Epi)Genetic Mechanisms Underlying the Evolutionary Success of Eusocial Insects

Genetic toolkit for sociality predicts castes across the spectrum of social complexity in wasps

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