Epigenetic regulation of TGF-β pathway and its role in radiation response

Ding, Yunan; Zhou, Guangming; Hu, Wentao

doi:10.1080/09553002.2024.2327395

Cited by 1 publication

(1 citation statement)

References 188 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, overexpression of TGF-β can cause the formation of cancer-associated fibroblasts, extracellular matrix, and epithelial–mesenchymal transition (EMT), which could lead to cancer ( 139 ). TGF-β pathway plays a dual role in cancer progression ( 140 , 141 ); it is an inhibitor of tumor cell growth and an inducer of tumor metastasis ( 142 ), thereby playing an important role in the development and metastasis of tumors ( 143 ). TGF-β functions mainly by binding to the corresponding ligands, which are divided into three main classes, namely cell surface type I and type II serine/serine kinase receptors (TGFβRI and TGFβRII, respectively) and co-receptors endobilin and β-glycans (termed type III receptors or TGFβRIII) ( 144 ).…”

Section: Mscs-derived Exosomes (Mscs-exo) In Cancer Therapymentioning

confidence: 99%

Different origin-derived exosomes and their clinical advantages in cancer therapy

Jin,

Zhang,

Zhang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Exosomes, as a class of small extracellular vesicles closely related to the biological behavior of various types of tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding cancer diagnosis, the stability of their membrane structure and their wide distribution in body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor diagnosis in the future. For cancer treatment, exosomes, as the “golden communicators” between cells, can be designed to deliver different drugs, aiming to achieve low-toxicity and low-immunogenicity targeted delivery. Signaling pathways related to exosome contents can also be used for safer and more effective immunotherapy against tumors. Exosomes are derived from a wide range of sources, and exhibit different biological characteristics as well as clinical application advantages in different cancer therapies. In this review, we analyzed the main sources of exosomes that have great potential and broad prospects in cancer diagnosis and therapy. Moreover, we compared their therapeutic advantages, providing new ideas for the clinical application of exosomes.

show abstract