Epigenetic Regulation of Placental <i>NR3C1</i>: Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?

Stroud, Laura R.; Papandonatos, George D.; Salisbury, Amy L.; Phipps, Maureen G.; Huestis, Marilyn A.; Niaura, Raymond; Padbury, Jamés F.; Marsit, Carmen J.; Lester, Barry M.

doi:10.1111/cdev.12482

Cited by 47 publications

(44 citation statements)

References 53 publications

(104 reference statements)

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“…R. Stroud, R. L. Paster, M. S. Goodwin, et al, 2009). We found decreased ability to self-regulate reactions to environmental stimuli (self-regulation/need for external handling), decreased ability to attend to stimuli (attention), and altered motor activity (lethargy) in MSDP-exposed vs. comparison infants (Law et al, 2003; Stroud, Papandonatos, Salisbury, et al, 2016; Stroud, Paster, Papandonatos, et al, 2009). Additional studies have found increased odds of MSDP exposure in NNNS profiles characterized by altered arousal, activity, muscle tone, attention, and signs of stress (Appleton et al, 2016; Liu et al, 2010).…”

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confidence: 82%

“…Our group conducted some of the first studies of associations between MSDP and infant neurobehavior using the NICU Network Neurobehavioral Scale (NNNS, behavior exam designed to be sensitive to subtle deficits in substance-exposed infants) and rigorous measures of MSDP including prospective measures of timing, quantity, and biomarkers of exposure (Law et al, 2003; L. Stroud et al, 2009; Stroud, Papandonatos, Rodriguez, et al, 2014; Stroud, Papandonatos, Salisbury, et al, 2016; L. R. Stroud, R. L. Paster, M. S. Goodwin, et al, 2009).…”

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confidence: 99%

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Impact of maternal prenatal smoking on fetal to infant neurobehavioral development

2018

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Despite recent emphasis on the profound importance of the fetal environment in "programming" postnatal development, measurement of offspring development typically begins after birth. Using a novel coding strategy combining direct fetal observation via ultrasound and actocardiography, we investigated the impact of maternal smoking during pregnancy (MSDP) on fetal neurobehavior; we also investigated links between fetal and infant neurobehavior. Participants were 90 pregnant mothers and their infants (52 MSDP-exposed; 51% minorities; ages 18-40). Fetal neurobehavior at baseline and in response to vibro-acoustic stimulus was assessed via ultrasound and actocardiography at M = 35 weeks gestation and coded via the Fetal Neurobehavioral Assessment System (FENS). After delivery, the NICU Network Neurobehavioral Scale was administered up to seven times over the first postnatal month. MSDP was associated with increased fetal activity and fetal limb movements. Fetal activity, complex body movements, and cardiac-somatic coupling were associated with infants' ability to attend to stimuli and to self-regulate over the first postnatal month. Furthermore, differential associations emerged by MSDP group between fetal activity, complex body movements, quality of movement, and coupling, and infant attention and self-regulation. The present study adds to a growing literature establishing the validity of fetal neurobehavioral measures in elucidating fetal programming pathways.

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confidence: 82%

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confidence: 99%

Impact of maternal prenatal smoking on fetal to infant neurobehavioral development

2018

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“…39 Alternatively, epigenetic effects may explain these effects of maternal smoking; for example, PTE seems to alter DNA methylation which may cause or signal a risk for smoking 11 and other adverse outcomes. 40 Other hereditary effects not included in this study, such as behavioral disinhibition or other personality traits, 41 could also explain these findings.…”

Section: Discussionmentioning

confidence: 85%

The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers

Selya

Cannon

Weiss

et al. 2018

Addictive Behaviors

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“…A recent study showed that maternal smoking during pregnancy induced hypomethylation at CpG3 and CpG4 in total 13 CpG of the placental NR3C1 gene, which has shown associations with newborn behavior [160]. Prenatal smoke exposure is known to result in a persistent effect on DNA methylation levels in adult peripheral blood granulocytes, as measured by repetitive element satellite 2 (Sat2) [161].…”

Section: Epigenetic Alterations By Environmental Toxicantsmentioning

confidence: 99%

Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism

Tran

Miyake

2017

International Journal of Genomics

116

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The increasing prevalence of neurodevelopmental disorders, especially autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD), calls for more research into the identification of etiologic and risk factors. The Developmental Origin of Health and Disease (DOHaD) hypothesizes that the environment during fetal and childhood development affects the risk for many chronic diseases in later stages of life, including neurodevelopmental disorders. Epigenetics, a term describing mechanisms that cause changes in the chromosome state without affecting DNA sequences, is suggested to be the underlying mechanism, according to the DOHaD hypothesis. Moreover, many neurodevelopmental disorders are also related to epigenetic abnormalities. Experimental and epidemiological studies suggest that exposure to prenatal environmental toxicants is associated with neurodevelopmental disorders. In addition, there is also evidence that environmental toxicants can result in epigenetic alterations, notably DNA methylation. In this review, we first focus on the relationship between neurodevelopmental disorders and environmental toxicants, in particular maternal smoking, plastic-derived chemicals (bisphenol A and phthalates), persistent organic pollutants, and heavy metals. We then review studies showing the epigenetic effects of those environmental factors in humans that may affect normal neurodevelopment.

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Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Neurobehavior by Maternal Smoking?

Cited by 47 publications

References 53 publications

Impact of maternal prenatal smoking on fetal to infant neurobehavioral development

Impact of maternal prenatal smoking on fetal to infant neurobehavioral development

The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers

Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism

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