2011
DOI: 10.1002/ijc.25919
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Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that play fundamental roles in diverse biological and pathological processes by targeting the expression of specific genes. Here, we identified 38 methylation-associated miRNAs, the expression of which could be epigenetically restored by cotreatment with 5-aza-2 0 -deoxycytidine and trichostatin A. Among these 38 miRNAs, we further analyzed miR-34b, miR-127-3p, miR-129-3p and miR-409 because CpG islands are predicted adjacent to them. The methylation-silenced express… Show more

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Cited by 170 publications
(128 citation statements)
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“…Recently, it was reported that miR-409 may be subjected to epigenetic modulation in GC, which in turn may be responsible for miR-409-3p downregulation in GC. 33 Taken together, these results suggest that reduced miR-409-3p is a frequent event in human GC and that patients with downregulated miR-409-3p are prone to lymph node metastasis. The capability of cell migration and invasion is considered to be one of the important determinants in the process of cancer metastasis.…”
Section: Discussionmentioning
confidence: 61%
“…Recently, it was reported that miR-409 may be subjected to epigenetic modulation in GC, which in turn may be responsible for miR-409-3p downregulation in GC. 33 Taken together, these results suggest that reduced miR-409-3p is a frequent event in human GC and that patients with downregulated miR-409-3p are prone to lymph node metastasis. The capability of cell migration and invasion is considered to be one of the important determinants in the process of cancer metastasis.…”
Section: Discussionmentioning
confidence: 61%
“…These results indicate that dysregulation of hypermethylation concurrently regulates the three pri-miR-9 paralogous human AGS gastric cancer cells following the treatment of DNA demethylation agents and identified several methylation-associated miRNAs, including miR-9. 9 We now demonstrated that the expression levels of mature miR-9 were modulated through DNA demethylation treatment at various time periods (0-4 days after treatment) in AGS cells (Fig. 1A).…”
Section: O N O T D I S T R I B U T Ementioning
confidence: 63%
“…Recent studies have indicated that several miRNAs, including miR-34b/c, miR-129, miR-137, miR-181C, miR-199a, miR-212, miR-512 and miR-516, were dysregulated and showed aberrant methylation patterns in gastric cancer cells. 6,9,[14][15][16][17][18][19][20][21] The three pri-miR-9 transcripts are all located within non-protein coding transcripts (Fig. 2A).…”
Section: Cell Lines and 5-aza-dc Treatmentmentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, emerging evidence suggested that miRNAs play significant roles in the initiation, progression, and survival prediction of GC by regulating cell proliferation, invasion, and migration [5,6]. MiR-129-5p, one of the mature forms of miR-129-1 and miR-129-2, has been reported to be involved in various neoplastic processes, including GC [7][8][9]. It has been demonstrated that miR-129-5p serves as an important tumor suppressor, and overexpression of miR-129-5p could significantly decrease the cell proliferation activity of multiple tumor cell lines, such as endometrial tumor cells, lung adenocarcinoma cell lines, bladder cancer cells, and GC cells [7,[10][11][12].…”
mentioning
confidence: 99%