Epigenetic Regulation of miR-22 in a BPA-exposed Human Hepatoma Cell

Kim, Seung Jun; Yu, So-Yeon; Yoon, Hyojung; Lee, Seung Yong; Youn, Jong-Phil; Hwang, Seung Yong

doi:10.1007/s13206-014-9110-2

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…There is a plethora of mechanisms BPA can utilize to alter miRNA functions: methylation levels of miRNA promoters [ 42 ], activity of miRNA activators/inhibitors, miRNA transcription factors [ 43 ]. Studies have reported BPA-induced disruptions of cell cycle progression, apoptosis, and steroidogenesis [ 44 , 45 , 46 ], all of which are largely regulated by miRNAs [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition

Sabry

Williams

Werry

et al. 2022

IJMS

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microRNAs (miRNAs) are susceptible to environmental factors that might affect cellular function and impose negative effects on female reproduction. miR-21 is the most abundant miRNA in bovine granulosa cells and is widely reported as affected by Bisphenol A (BPA) exposure, yet the cause and consequences are not entirely elucidated. BPA is a synthetic endocrine disruptor associated with poor fertility. miR-21 function in bovine granulosa cells is investigated utilizing locked nucleic acid (LNA) oligonucleotides to suppress miR-21. Before measuring apoptosis and quantifying miR-21 apoptotic targets PDCD4 and PTEN, transfection was optimized and validated. BPA was introduced to see how it affects miR-21 regulation and which BPA-mediated effects are influenced by miR-21. miR-21 knockdown and specificity against additional miRNAs were confirmed. miR-21 was found to have antiapoptotic effects, which could be explained by its effect on the proapoptotic target PDCD4, but not PTEN. Previous findings of miR-21 overexpression were validated using BPA treatments, and the temporal influence of BPA on miR-21 levels was addressed. Finally, BPA effects on upstream regulators, such as VMP1 and STAT3, explain the BPA-dependent upregulation of miR-21 expression. Overall, this research enhances our understanding of miR-21 function in granulosa cells and the mechanisms of BPA-induced reproductive impairment.

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Section: Discussionmentioning

confidence: 99%

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition

Sabry

Williams

Werry

et al. 2022

IJMS

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“…Among the aberrantly regulated microRNAs, miR-22-3p was the most strikingly downregulated. MiR-22-3p is a highly conserved microRNA with multiple functions, such as epigenetic modification ( Kim et al., 2015b ), cell differentiation ( Zhao et al., 2015 ), tumorigenesis ( Zuo et al., 2015 ), and disease development ( Huang et al., 2013 ). According to the earliest studies on miR-22-3p, the role of this microRNA in cellular proliferation and apoptosis is context dependent.…”

Section: Discussionmentioning

confidence: 99%

Transplantation of IGF-1-induced BMSC-derived NPCs promotes tissue repair and motor recovery in a rat spinal cord injury model

Al-Zikri

Huat

Khan

et al. 2022

Heliyon

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“…Furthermore, Li and colleagues highlighted the important role of miR-19 in BPAmediated MCF-7 cell proliferation, suggesting for the first time that curcumin modulates the miR-19/PTEN/AKT/p53 axis to exhibit its protective effects against BPA-associated breast cancer. Kim et al (2015) [34] used HepG2 cells that are widely used as a model system for studies of liver metabolism and genotoxicity. In particular, the authors determined the role of BPA exposure in the epigenetically affected expression of miR-22.…”

Section: Summary Of Literature Includedmentioning

confidence: 99%

Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review

Ferrante

Cristaldi

Conti

2021

JPM

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The daily environmental exposure of humans to plasticizers may adversely affect human health, representing a global issue. The altered expression of microRNAs (miRNAs) plays an important pathogenic role in exposure to plasticizers. This systematic review summarizes recent findings showing the modified expression of miRNAs in cancer due to exposure to plasticizers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology, we performed a systematic review of the literature published in the past 10 years, focusing on the relationship between plasticizer exposure and the expression of miRNAs related to cancer. Starting with 535 records, 17 articles were included. The results support the hypothesis that exposure to plasticizers causes changes in or the deregulation of a number of oncogenic miRNAs and show that the interaction of plasticizers with several redundant miRNAs, such as let-7f, let-7g, miR-125b, miR-134, miR-146a, miR-22, miR-192, miR-222, miR-26a, miR-26b, miR-27b, miR-296, miR-324, miR-335, miR-122, miR-23b, miR-200, miR-29a, and miR-21, might induce deep alterations. These genotoxic and oncogenic responses can eventually lead to abnormal cell signaling pathways and metabolic changes that participate in many overlapping cellular processes, and the evaluation of miRNA-level changes can be a useful target for the toxicological assessment of environmental pollutants, including plastic additives and plasticizers.

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Epigenetic Regulation of miR-22 in a BPA-exposed Human Hepatoma Cell

Cited by 12 publications

References 30 publications

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition

Transplantation of IGF-1-induced BMSC-derived NPCs promotes tissue repair and motor recovery in a rat spinal cord injury model

Oncogenic Role of miRNA in Environmental Exposure to Plasticizers: A Systematic Review

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