Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

Lian, Yishui; Meng, Lingjiao; Ding, Pingan; Sang, Meixiang

doi:10.1186/s13148-018-0550-8

Cited by 54 publications

(56 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cancer cells, MAGE-A members show abnormal expression, leading to the acquisition of tumor-promoting properties such as tumor growth, proliferation, migration, and invasion with concomitant inhibition to apoptosis [5]. The abnormal activation of MAGE family genes is now attributed to epigenetic dysregulation such as DNA hypomethylation, defective histone modifications, and nucleosome occupancy [16]. DNA hypomethylation has been shown to induce aberrant expression of MAGE-A genes and is associated with poor survival outcomes in laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma [87,88].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

2020

View full text Add to dashboard Cite

Background Members of the melanoma-associated antigen-A (MAGE-A) subfamily are overexpressed in many cancers and can drive cancer progression, metastasis, and therapeutic recurrence. Objective This study is the first comprehensive meta-analysis evaluating the prognostic utility of MAGE-A members in different cancers. Methods A systematic literature search was conducted in PubMed, Google Scholar, Science Direct, and Web of Science. The pooled hazard ratios with 95% confidence intervals were estimated to evaluate the prognostic significance of MAGE-A expression in various cancers. Results In total, 44 eligible studies consisting of 7428 patients from 11 countries were analysed. Univariate and multivariate analysis for overall survival, progression-free survival, and disease-free survival showed a significant association between high MAGE-A expression and various cancers (P < 0.00001). Additionally, subgroup analysis demonstrated that high MAGE-A expression was significantly associated with poor prognosis for lung, gastrointestinal, breast, and ovarian cancer in both univariate and multivariate analysis for overall survival. Conclusion Overexpression of MAGE-A subfamily members is linked to poor prognosis in multiple cancers. Therefore, it could serve as a potential prognostic marker of poor prognosis in cancers.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

2020

View full text Add to dashboard Cite

show abstract

“…The panel included 10 target genes (TERT, ZAP70, GP1BB, LRRTM1, FLI1, MiR124-1, MiR296, KIF1A, PARP15 and MAGEC2), selected because their human orthologs were previously identified with altered methylation pattern in human head and neck squamous cell carcinoma (SCC). 17,22,25,[32][33][34][35][36] In order to identify putative CpG islands on promoter region of genes or in the first part of the coding region, genomic sequence stored on the Ensembl genome browser (http://www.ensembl.org/index.html) were employed as query sequence, considering the best homology of each feline gene region with human orthologues. the MethPrimer (http://www.urogene.org/cgi-bin/methprimer/methprimer.cgi) designing was applied to identify CpGs and the best primers of choice.…”

Section: Dna Methylation Analysismentioning

confidence: 99%

Analysis of DNA methylation and TP53 mutational status for differentiating feline oral squamous cell carcinoma from non‐neoplastic mucosa: A preliminary study

Renzi

Morandi

Lenzi

et al. 2020

Vet Comparative Oncology

View full text Add to dashboard Cite

Feline oral squamous cell carcinoma (FOSCC) is characterized by high local invasiveness and early bone lysis. The late diagnosis largely limits the efficacy of therapy and increases treatment-related morbidity. The aim of this exploratory study was to assess the methylation pattern of 10 candidate genes and TP53 mutational status in histologic samples of FOSCC. Results were compared with normal oral mucosa and oral inflammatory lesions, in order to establish a gene panel for FOSCC detection. For 10 cats, the above analyses were also performed on oral brushing samples, in order to explore the utility of these methods for screening purposes. Thirty-one FOSCC, 25 chronic inflammatory lesions and 12 controls were included. TP53 mutations were significantly more frequent in the FOSCC (68%) than in the non-neoplastic oral mucosa (3%; P <.001). Based on lasso regression analysis, a step-wise algorithm including TP53, FLI1, MiR124-1, KIF1A and MAGEC2 was proposed. The algorithm allowed to differentiate FOSCC with 94% sensitivity and 100% specificity (accuracy, 97%). When applying the proposed algorithm on 10 brushing samples, accuracy decreased to 80%. These results indicate that the altered DNA methylation of specific genes is present in FOSCC, together with a significant proportion of TP53 mutations. Such alterations are infrequent in normal oral mucosa and chronic stomatitis in cats, suggesting their involvement in feline oral carcinogenesis and their utility as diagnostic biomarkers. Further studies on a high number of brushing samples will be needed to assess the utility of a screening test for the early detection of FOSCC.

show abstract

“…It is important to understand how germline genes are repressed in somatic tissue as many human somatic cancers that are highly proliferative and metastatic show upregulation of germline genes (Gure et al, 2005;Maine et al, 2016;Xu et al, 2014). Like C. elegans, mammals also repress germline gene expression during embryogenesis in somatic cells and recent work has indicated that this repression is dependent on H3K9me2 (Ebata et al, 2017;Lian et al, 2018). Given that the DREAM complex is completely conserved between worms and mammals (Litovchick, et al, 2007), its role in establishment of developmental repressive chromatin at germline genes may also be conserved.…”

Section: Discussionmentioning

confidence: 99%

C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development

Costello

Petrella

2019

Development

View full text Add to dashboard Cite

Tissue-specific establishment of repressive chromatin through creation of compact chromatin domains during development is necessary to ensure proper gene expression and cell fate. Caenorhabditis elegans synMuv B proteins are important for the soma/germline fate decision and mutants demonstrate ectopic germline gene expression in somatic tissue, especially at high temperature. We show that C. elegans synMuv B proteins regulate developmental chromatin compaction and that the timing of chromatin compaction is temperature sensitive in both wild type and synMuv B mutants. Chromatin compaction in mutants is delayed into developmental time periods when zygotic gene expression is upregulated and demonstrates an anterior-to-posterior pattern. Loss of this patterned compaction coincides with the developmental time period of ectopic germline gene expression, which leads to a developmental arrest in synMuv B mutants. Finally, accelerated cell division rates at elevated temperature may contribute to a lack of coordination between expression of tissue specific transcription programs and chromatin compaction at high temperature. Thus, chromatin organization during development is regulated both spatially and temporally by synMuv B proteins to establish repressive chromatin in a tissue-specific manner to ensure proper gene expression.

show abstract

Epigenetic regulation of MAGE family in human cancer progression-DNA methylation, histone modification, and non-coding RNAs

Cited by 54 publications

References 91 publications

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene Expression in Various Human Cancers: A Systematic Review and Meta-analysis of 7428 Patients and 44 Studies

Analysis of DNA methylation and TP53 mutational status for differentiating feline oral squamous cell carcinoma from non‐neoplastic mucosa: A preliminary study

C. elegans synMuv B proteins regulate spatial and temporal chromatin compaction during development

Contact Info

Product

Resources

About