Epigenetic regulation of inflammation in insulin resistance

Klimczak, S; Śliwińska, Agnieszka

doi:10.1016/j.semcdb.2022.09.004

Cited by 6 publications

(11 citation statements)

References 61 publications

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“…N 6 -methyladenosine (m 6 A) refers to methylation of adenosine at the nitrogen-6 position and is the most common internal messenger RNA modification in humans (64). Alterations in m 6 A promote ROS, telomere shortening, DNA damage, and pro-inflammatory functions, eventually leading to cellular senescence (65). T2DM results in m 6 A hypomethylation of genes involved in cell cycle progression, insulin release, and several insulin signaling pathways (66).…”

Section: Epigenetics and Cellular Senescence In T2dmmentioning

confidence: 99%

“…Alterations in m 6 A promote ROS, telomere shortening, DNA damage, and pro-inflammatory functions, eventually leading to cellular senescence (65). T2DM results in m 6 A hypomethylation of genes involved in cell cycle progression, insulin release, and several insulin signaling pathways (66). Reduced m 6 A in b-cells results in cell cycle arrest and impairs insulin release via decreased AKT phosphorylation and PDX1 protein levels (66).…”

Section: Epigenetics and Cellular Senescence In T2dmmentioning

confidence: 99%

“…Several epigenetic modifications have been identified. The most commonly studied mechanism is DNA methylation, a crucial epigenetic modification, primarily functions to regulate gene expression by adding methyl groups to cytosine residues in DNA, often leading to the suppression of gene activity and affecting cellular differentiation, development, and disease pathogenesis ( 3 ). This process almost always occurs in CpG regions, where 70% of methylation events occur ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, non-coding ribonucleic acids (ncRNAs) represent another essential facet of epigenetics ( 3 ). These RNA molecules, which are transcribed but not translated into proteins, are involved in genetic silencing.…”

Section: Introductionmentioning

confidence: 99%

“…These RNA molecules, which are transcribed but not translated into proteins, are involved in genetic silencing. Beyond this, emerging evidence highlights the role of ncRNAs in orchestrating epigenetic modifications, further underscoring their significance in gene regulation ( 3 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

Jazieh,

Arabi,

Asim

et al. 2024

Front. Endocrinol.

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Type 2 diabetes mellitus (T2DM) is a rapidly escalating global health concern, with its prevalence projected to increase significantly in the near future. This review delves into the intricate role of epigenetic modifications - including DNA methylation, histone acetylation, and micro-ribonucleic acid (miRNA) expression - in the pathogenesis and progression of T2DM. We critically examine how these epigenetic changes contribute to the onset and exacerbation of T2DM by influencing key pathogenic processes such as obesity, insulin resistance, β-cell dysfunction, cellular senescence, and mitochondrial dysfunction. Furthermore, we explore the involvement of epigenetic dysregulation in T2DM-associated complications, including diabetic retinopathy, atherosclerosis, neuropathy, and cardiomyopathy. This review highlights recent studies that underscore the diagnostic and therapeutic potential of targeting epigenetic modifications in T2DM. We also provide an overview of the impact of lifestyle factors such as exercise and diet on the epigenetic landscape of T2DM, underscoring their relevance in disease management. Our synthesis of the current literature aims to illuminate the complex epigenetic underpinnings of T2DM, offering insights into novel preventative and therapeutic strategies that could revolutionize its management.

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Section: Epigenetics and Cellular Senescence In T2dmmentioning

confidence: 99%

Section: Epigenetics and Cellular Senescence In T2dmmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

Jazieh,

Arabi,

Asim

et al. 2024

Front. Endocrinol.

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Epigenetic regulation of inflammation

Ahmad

2024

Seminars in Cell & Developmental Biology

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Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview

Luong,

Guan,

Vue

et al. 2024

IJERPH

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Type 2 diabetes mellitus (T2DM) is a public health condition where environmental and genetic factors can intersect through hydroxymethylation. It was unclear which blood DNA regions were hydroxymethylated in human T2DM development. We aimed to identify the regions from the literature as designed in the ongoing Twins Discordant for Incident T2DM Study. A scoping review was performed using Medical Subject Headings (MeSH) and keyword methods to search PubMed for studies published in English and before 1 August 2022, following our registered protocol. The keyword and MeSH methods identified 12 and 3 records separately, and the keyword-identified records included all from the MeSH. Only three case-control studies met the criteria for the full-text review, including one MeSH-identified record. Increased global levels of 5-hydroxymethylated cytosine (5hmC) in T2DM patients versus healthy controls in blood or peripheral blood mononuclear cells were consistently reported (p < 0.05 for all). Among candidate DNA regions related to the human SOCS3, SREBF1, and TXNIP genes, only the SOCS3 gene yielded higher 5hmC levels in T2DM patients with high poly-ADP-ribosylation than participants combined from those with low PARylation and healthy controls (p < 0.05). Hydroxymethylation in the SOCS3-related region of blood DNA is promising to investigate for its mediation in the influences of environment on incident T2DM.

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Epigenetic regulation of inflammation in insulin resistance

Cited by 6 publications

References 61 publications

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

Unraveling the epigenetic fabric of type 2 diabetes mellitus: pathogenic mechanisms and therapeutic implications

Epigenetic regulation of inflammation

Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview

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