Epigenetic regulation of fetal brain development in pig

Strawn, Monica; Behura, Susanta K.

doi:10.1016/j.gene.2022.146823

Cited by 5 publications

(3 citation statements)

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“…We compared blood methylations of adult blood with methylation profiles from developing fetal brain at three gestation days (GDs) 46, 60 and 90 generated from our earlier study (accession number GSE178983) [14]. The fetal brain methylation data showed a common core of 69,757 methylation sites was observed across the three GDs in both sexes ( Supplementary Figure 1 ) indicating that these methylations were persistent during fetal brain development (henceforth referred to as Fetal Brain Methylations or FBMs).…”

Section: Resultsmentioning

confidence: 99%

“…The results of this analysis suggested these methylations occurred largely in genes that significantly altered prior to the rapid growth of fetal brain which occurred after gestation day 60. We have recently shown the importance of DNA methylation in gene regulation of fetal brain development in pig [14]. In addition, several genes were also related to transport function.…”

Section: Discussionmentioning

confidence: 99%

“…Studies by other have shown that gene expression in pig brain is influenced by various epigenetic factors including chromatin modification and DNA methylation [13]. Recently, we studied epigenetic changes during development of fetal brain in pig [14]. Multi-tissue analysis by others has identified methylation sites associated with aging in pig [15].…”

Section: Introductionmentioning

confidence: 99%

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Can blood at adult age predict epigenetic changes of the brain during fetal stages?

Strawn

Safranski

Behura

2022

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Correspondence in DNA methylation between blood and brain is known in humans. If this pattern is present in pig has not been examined. In this study, we profiled DNA methylation of blood from pigs at adult ages, and compared those with the methylation profiles of fetal brain. Neural network regression modeling showed specific methylations in the adult blood that can reliably predict methylation of the fetal brain. Genes associated with these predictive methylations included markers of specific cell types of blood and brain, in particular, markers of bone marrow hematopoietic progenitors, and glial cells primarily the ependymal and Schwann cells of brain. The results of this study show that developmental methylation changes of the brain during fetal stages are maintained as an epigenetic memory in the blood in adult life. Thus, pig models may be harnessed to uncover potential roles of epigenetic memory in brain health and diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%