Epigenetic Regulation of Endothelial Function: With Focus on MicroRNAs

Roque, Fernanda Roberta; Nóbrega, Clara; Fernandes, Tiago; Oliveira, Edilamar Menezes de

doi:10.1016/b978-0-12-812348-5.00013-1

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2019

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“…Different mechanisms are involved in epigenetic-mediated carcinogenesis, each of them was extensively studied during the last four decades [6]. Interestingly, newly developed epigenetic-based cancer therapies provide unique and validated approach to treat different types of cancers [13,14].…”

Section: Introductionmentioning

confidence: 99%

Cancer Epigenetics: Shifting to More Deep Action

Sabit

Abdel-Ghany

Çevik

et al. 2019

NACS

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Cancer is a major health problem facing the entire human population. It affects almost every race, gender, or age in the social hierarchy. Many mechanisms have been proposed for the development of cancer; either genetic or epigenetic. Over the years, a cumulative body of research indicated that epigenetic mutations (epimutations) represent a chief player in the course of cancer, where it affects cell proliferation, cancer initiation, progression, apoptosis, and metastasis. In this minireview we highlight the main mechanisms of epigenetic-mediated cancer development with emphasis on the environmental pollution role in this arena.

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Section: Introductionmentioning

confidence: 99%