Epigenetic regulation of DHRS2 by SUV420H2 inhibits cell apoptosis in renal cell carcinoma

Ryu, Tae Young; Lee, Jinkwon; Kang, Yunsang; Son, Mi‐Young; Kim, Dae-Soo; Lee, Youn su; kim, Mi-Young; Cho, Hyun Soo

doi:10.1016/j.bbrc.2023.04.066

Cited by 2 publications

(2 citation statements)

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“…In renal cell carcinoma, SUV4-20H2 was shown to epigenetically regulate cell proliferation through targeting of dehydrogenase/reductase 2 (DHRS2) [ 59 ]. Using the A498 clear cell renal cancer cell line, representative of the majority of kidney cancers, it was demonstrated that silencing of the methyltransferase suppressed growth and induced cell apoptosis through attenuation of H4K20me3 levels on the promoter of DHRS2 .…”

Section: Involvement Of Suv4-20h2 In Cancermentioning

confidence: 99%

“…It is of note that simultaneous silencing of KMT5C and DHRS2 rescued the phenotype, while the use of SUV4-20 family protein inhibitor A-196 resulted in cell apoptosis by increasing the levels of DHRS2. Furthermore, the research data highlight the higher levels of SUV4-20H2 in renal cell carcinoma patients ( Table 2 ) and their association with poor prognosis [ 59 ].…”

Section: Involvement Of Suv4-20h2 In Cancermentioning

confidence: 99%

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Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential

Papadaki,

Piperi

2024

IJMS

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Histone lysine methyltransferase SUV4-20H2, a member of the suppressor of variegation 4–20 homolog (SUV4-20) family, has a critical impact on the regulation of chromatin structure and gene expression. This methyltransferase establishes the trimethylation of histone H4 lysine 20 (H4K20me3), a repressive histone mark that affects several cellular processes. Deregulated SUV4-20H2 activity has been associated with altered chromatin dynamics, leading to the misregulation of key genes involved in cell cycle control, apoptosis and DNA repair. Emerging research evidence indicates that SUV4-20H2 acts as a potential epigenetic modifier, contributing to the development and progression of several malignancies, including breast, colon and lung cancer, as well as renal, hepatocellular and pancreatic cancer. Understanding the molecular mechanisms that underlie SUV4-20H2-mediated effects on chromatin structure and gene expression may provide valuable insights into novel therapeutic strategies for targeting epigenetic alterations in cancer. Herein, we discuss structural and functional aspects of SUV4-20H2 in cancer onset, progression and prognosis, along with current targeting options.

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Section: Involvement Of Suv4-20h2 In Cancermentioning

confidence: 99%

Section: Involvement Of Suv4-20h2 In Cancermentioning

confidence: 99%