Epigenetic regulation of autophagy in coronavirus disease 2019 (COVID-19)

Non-coding RNA transcripts, incredible modulators of cisplatin chemo-resistance in bladder cancer through operating a broad spectrum of cellular processes and signaling mechanism

“…To the best of our knowledge, autophagy is an evolutionarily conserved flux responsible for self-catabolic organelle recycle that is principally activated due to starvation, cellular stress, and the presence of reactive oxygen species (ROS) to protect against exacerbation of the circumstances [ 225 , 226 ]. Autophagy acts as a double-edged sword; for instance, sufficient autophagy maintains a steady state of an organ, while its excessive activation may induce the progression of organ failure [ 227 ]. In this regard, chemo-resistant tumors can undesirably keep themselves alive by over-activating the autophagy flux.…”