Epigenetic regulation of autophagy by non-coding RNAs in gastrointestinal tumors: Biological functions and therapeutic perspectives

Zandieh, Mohammad Arad; Farahani, Melika Heydari; Rajabi, Romina; avval, Shamim Tavakkoli; Karimi, Kimia; Rahmanian, Parham; Razzazan, Mehrnaz; Javanshir, Salar; Mirzaei, Sepideh; Paskeh, Mahshid Deldar Abad; Salimimoghadam, Shokooh; Hushmandi, Kiavash; Taheriazam, Afshin; Pandey, Vijay; Hashemi, Mehrdad

doi:10.1016/j.phrs.2022.106582

Cited by 8 publications

(4 citation statements)

References 279 publications

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“…MiRNAs can influence genes, with thousands of miRNAs regulating approximately 60% of the genes. Their principal function involves binding to recognition sites in the 3' untranslated region, thereby reducing mRNA stability and suppressing gene expression [ 130 , 131 ].…”

Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

“…LncRNAs play a regulatory role in protein and miRNA functions and expression levels and contribute to chromatin remodelling [ 130 , 132 ]. Some lncRNAs are considered valuable biomarkers for PDAC because they mediate various processes involved in tumour cell progression, making them applicable for liquid biopsy in PDAC [ 122 ].…”

Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

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Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Wang,

Pan

et al. 2023

Mol Cancer

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Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a potential curative approach for PC, but most patients are unsuitable for operations when at the time of diagnosis. Even with surgery, some patients may still experience tumour metastasis during the operation or shortly after surgery, as precise prognosis evaluation is not always possible. If patients miss the opportunity for surgery and resort to chemotherapy, they may face the challenging issue of chemotherapy resistance. In recent years, liquid biopsy has shown promising prospects in disease diagnosis, treatment monitoring, and prognosis assessment. As a noninvasive detection method, liquid biopsy offers advantages over traditional diagnostic procedures, such as tissue biopsy, in terms of both cost-effectiveness and convenience. The information provided by liquid biopsy helps clinical practitioners understand the molecular mechanisms underlying tumour occurrence and development, enabling the formulation of more precise and personalized treatment decisions for each patient. This review introduces molecular biomarkers and detection methods in liquid biopsy for PC, including circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), noncoding RNAs (ncRNAs), and extracellular vesicles (EVs) or exosomes. Additionally, we summarize the applications of liquid biopsy in the early diagnosis, treatment response, resistance assessment, and prognostic evaluation of PC.

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Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

Section: Biomarkers and Detection Methodsmentioning

confidence: 99%

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Wang,

Pan

et al. 2023

Mol Cancer

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“…Recent studies have found that epigenetic regulation and relevant therapeutics play an irreplaceable role in the Due to the heterogeneity of tumor cells, tumor recurrence and drug resistance frequently occur, which are the main reasons for the high mortality of cancer. In the early stage of tumor development, numbers of epigenetic changes occur in tumor cells (Ka-Yue Chow et al, 2022;Zandieh et al, 2022). Therefore, it is essential to find drugs that can regulate the abnormal epigenetic regulation of tumor cells.…”

Section: Abstract Epigenetics Cancer Histone Epigenetic Drug Combined...mentioning

confidence: 99%

Recent advances in epigenetic anticancer therapeutics and future perspectives

Ren

Yang

et al. 2023

Front. Genet.

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Tumor development is frequently accompanied by abnormal expression of multiple genomic genes, which can be broadly viewed as decreased expression of tumor suppressor genes and upregulated expression of oncogenes. In this process, epigenetic regulation plays an essential role in the regulation of gene expression without alteration of DNA or RNA sequence, including DNA methylation, RNA methylation, histone modifications and non-coding RNAs. Therefore, drugs developed for the above epigenetic modulation have entered clinical use or preclinical and clinical research stages, contributing to the development of antitumor drugs greatly. Despite the efficacy of epigenetic drugs in hematologic caners, their therapeutic effects in solid tumors have been less favorable. A growing body of research suggests that epigenetic drugs can be applied in combination with other therapies to increase efficacy and overcome tumor resistance. In this review, the progress of epigenetics in tumor progression and oncology drug development is systematically summarized, as well as its synergy with other oncology therapies. The future directions of epigenetic drug development are described in detail.

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“…Moreover, tumor cells contain specific inhibitory Focal adhesion kinase (FAK) that activates Src family kinase (SRC), thereby inhibiting autophagy. 35 Autophagy plays an important role in RHCC. Furthermore, it acts as an important mediator of HCC cell invasion, inducing changes in cell adhesion signaling and promoting HCC cell migration and glycolytic pathways.…”

Section: Role Of the Hif-1α/bnip3 Signaling Pathway In Rhccmentioning

confidence: 99%

Role of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine

Liu¹,

Kang²,

Song³

et al. 2023

JHC

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Recurrence of hepatocellular carcinoma (HCC) negatively affects the quality of life of patients and leads to death. Studies have shown that recurrent hepatocellular carcinoma (RHCC) is closely related to tissue hypoxia and autophagy. It has been shown that hypoxia-inducible factor-1α (HIF-1α) and its downstream factor BCL-2 19 kDa-interacting protein 3 (BNIP3) promote cellular autophagy under hypoxic conditions, resulting in metastasis and RHCC. In this article, the molecular structures of HIF-1α and BNIP3 are described, and the significance of the HIF-1α/BNIP3 signaling pathway in RHCC is explained. Moreover, the role and mechanism of traditional Chinese medicine (TCM) in treating RHCC by modulating the HIF-1α/BNIP3 signaling pathway is discussed. Studies have shown that the HIF-1α/BNIP3 signaling pathway is a potential target of TCM in the treatment of RHCC. The mechanism of the HIF-1α/BNIP3 signaling pathway in RHCC and the progress achieved in TCM research on targeting and regulating this pathway are also reviewed in this article. The objective was to provide a theoretical basis for the prevention and treatment of RHCC, as well as further drug development.

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Epigenetic regulation of autophagy by non-coding RNAs in gastrointestinal tumors: Biological functions and therapeutic perspectives

Cited by 8 publications

References 279 publications

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation

Recent advances in epigenetic anticancer therapeutics and future perspectives

Role of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine

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