Epigenetic regulation in monocyte/macrophage: A key player during atherosclerosis

Jia, Sujie; Gao, Keqin; Zhao, Ming

doi:10.1111/1755-5922.12262

Cited by 35 publications

(24 citation statements)

References 133 publications

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“…In contrast, M2 macrophages display anti-inflammatory and repair activities to resolve inflammation and promote tissue repair (Ivashkiv, 2013;Murray et al, 2014). In general, M1 macrophages promote the progression of atherosclerotic plaque and its instability, whereas M2 macrophages inhibit the progression of atherosclerotic plaque and contribute to the stability of plaque ( Jia et al, 2017).…”

Section: Glutamine Promotes the Polarization Of M2 Macrophagesmentioning

confidence: 99%

Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease

Chen

Zhang

et al. 2020

DNA and Cell Biology

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Atherosclerosis is a major disease that seriously harms human health and is known as the ''number one killer'' in developed countries and the leading cause of death worldwide. Glutamine is the most abundant nonessential amino acid in the human blood that has multifaceted effects on the body. Recent studies showed that glutamine is negatively corrected with the progression of atherosclerotic lesions. In this review, we focused on the relationship of glutamine with macrophage polarization, nitrification stress, oxidative stress injury, myocardial ischemia-reperfusion injury, and therapeutic angiogenesis to review its roles in atherosclerotic cardiovascular disease.

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Section: Glutamine Promotes the Polarization Of M2 Macrophagesmentioning

confidence: 99%

Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease

Chen

Zhang

et al. 2020

DNA and Cell Biology

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“…In rat, overexpression of this gene in vascular smooth muscle cells induced cellular hypertrophy. These results suggest that gene-smoking interaction for atherosclerosis might be acting through an intensification of monocyte activation and recruitment under the endothelial layers before their differentiation into macrophages, a process known to trigger foam cell formation and subsequent plaques (Jia et al, 2017). The results from the functional analyses suggest that the genesmoking interaction for cIMT is likely acting through a regulatory process, explaining the involvement of multiple loci displaying chromatin interactions and acting as eQTLs.…”

Section: Discussionmentioning

confidence: 83%

Novel and Known Gene-Smoking Interactions With cIMT Identified as Potential Drivers for Atherosclerosis Risk in West-African Populations of the AWI-Gen Study

et al. 2020

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Introduction: Atherosclerosis is a key contributor to the burden of cardiovascular diseases (CVDs) and many epidemiological studies have reported on the effect of smoking on carotid intima-media thickness (cIMT) and its subsequent effect on CVD risk. Gene-environment interaction studies have contributed towards understanding some of the missing heritability of genome-wide association studies. Gene-smoking interactions on cIMT have been studied in non-African populations (European, Latino-American, and African American) but no comparable African research has been reported. Our aim was to investigate smoking-SNP interactions on cIMT in two West African populations by genome-wide analysis.Materials and methods: Only male participants from Burkina Faso (Nanoro = 993) and Ghana (Navrongo = 783) were included, as smoking was extremely rare among women. Phenotype and genotype data underwent stringent QC and genotype imputation was performed using the Sanger African Imputation Panel. Smoking prevalence among men was 13.3% in Nanoro and 42.5% in Navrongo. We analyzed gene-smoking interactions with PLINK after adjusting for covariates: age and 6 PCs (Model 1); age, BMI, blood pressure, fasting glucose, cholesterol levels, MVPA, and 6 PCs (Model 2). All analyses were performed at site level and for the combined data set. Results:In Nanoro, we identified new gene-smoking interaction variants for cIMT within the previously described RCBTB1 region (rs112017404, rs144170770, and rs4941649) (Model 1: p = 1.35E-07; Model 2: p = 3.08E-08). In the combined sample, two novel Frontiers in Genetics | www.frontiersin.org Discussion: This is the first gene-smoking interaction study for cIMT, as a risk factor for atherosclerosis, in sub-Saharan African populations. In addition to replicating previously known signals for RCBTB1, we identified two novel genomic regions (TBC1D8, near BCHE) involved in this gene-environment interaction.

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“…Among the known epigenetic factors are DNA methylation, histone modification, and the effects of various non-coding RNAs. Studying of epigenetic factors is challenging because of their complexity and dynamic nature, but also by the limited access to in vivo material and tissue heterogeneity, since epigenetic modifications are often cell type-specific [48]. These limitations make single cell analysis technologies.…”

Section: Epigenetic Factorsmentioning

confidence: 99%

In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models

Poznyak

Grechko

Wetzker

et al. 2020

IJMS

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Atherosclerosis is a multifactorial chronic disease that affects large arteries and may lead to fatal consequences. According to current understanding, inflammation and lipid accumulation are the two key mechanisms of atherosclerosis development. Animal models based on genetically modified mice have been developed to investigate these aspects. One such model is low-density lipoprotein (LDL) receptor knockout (KO) mice (ldlr −/− ), which are characterized by a moderate increase of plasma LDL cholesterol levels. Another widely used genetically modified mouse strain is apolipoprotein-E KO mice (apoE −/− ) that lacks the primary lipoprotein required for the uptake of lipoproteins through the hepatic receptors, leading to even greater plasma cholesterol increase than in ldlr −/− mice. These and other animal models allowed for conducting genetic studies, such as genome-wide association studies, microarrays, and genotyping methods, which helped identifying more than 100 mutations that contribute to atherosclerosis development. However, translation of the results obtained in animal models for human situations was slow and challenging. At the same time, genetic studies conducted in humans were limited by low sample sizes and high heterogeneity in predictive subclinical phenotypes. In this review, we summarize the current knowledge on the use of KO mice for identification of genes implicated in atherosclerosis and provide a list of genes involved in atherosclerosis-associated inflammatory pathways and their brief characteristics. Moreover, we discuss the approaches for candidate gene search in animals and humans and discuss the progress made in the field of epigenetic studies that appear to be promising for identification of novel biomarkers and therapeutic targets.challenge is the lack of effective treatment approaches, which is the consequence of our incomplete understanding of the processes that underlie the pathogenesis. Genetic base is one of the most important features that are involved in the disease development.Currently, the most widely used anti-atherosclerosis drugs are statins [3]. The aim of statin therapy is reducing the blood level of low-density lipoprotein (LDL) cholesterol, which is a well-known pro-atherogenic agent. It was demonstrated that statin therapy reduces the risk of cardiovascular events by approximately one third [4]. However, statin therapy alone cannot be regarded as effective treatment of atherosclerosis. Increasing the plasma levels of high-density lipoprotein (HDL), which has anti-atherogenic properties, is another promising approach. Accumulating evidence shows that high levels of HDL cholesterol can inhibit atherosclerosis progression. To date, several therapeutic agents that increase HDL levels are known, including niacin, fibrates, and statins. Among the recently developed medications are apoA-I-phospholipid complexes, human apoA-I and apoA-I-mimetic peptides, and inhibitors of cholesterol ester transfer protein, which have reached the level of clinical trials. However, the inhibitor ...

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Epigenetic regulation in monocyte/macrophage: A key player during atherosclerosis

Cited by 35 publications

References 133 publications

Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease

Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease

Novel and Known Gene-Smoking Interactions With cIMT Identified as Potential Drivers for Atherosclerosis Risk in West-African Populations of the AWI-Gen Study

In Search for Genes Related to Atherosclerosis and Dyslipidemia Using Animal Models

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