Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Shi, Yuncong; Zhang, Huanji; Huang, Suli; Yin, Li; Wang, Feng; Luo, Pei; Huang, Hui

doi:10.1038/s41392-022-01055-2

“…This has provided attractive options to mechanistically target macrophages as a therapeutic approach in slowing the progression of atherosclerosis [80][81][82][83]. Interest has been drawn to the interplay of long non-coding RNA (IncRNA) in macrophages and the development of atherosclerosis due to emerging research on IncRNAs that suggests they have a strong connection to the regulatory pathways of microRNAs [84,85]. While the roles of IncRNAs are still poorly understood in macrophages, the recent research has displayed promising results [86].…”

Section: Macrophages and Atherosclerosismentioning

confidence: 99%

“…In atherosclerotic LDLR-/-mice, MAARS was discovered to be a regulator of macrophage apoptosis, efferocytosis, and plaque necrosis through a direct interaction with the RNA-binding protein HuR [87]. The expression of MAARS increases Interest has been drawn to the interplay of long non-coding RNA (IncRNA) in macrophages and the development of atherosclerosis due to emerging research on In-cRNAs that suggests they have a strong connection to the regulatory pathways of mi-croRNAs [84,85]. While the roles of IncRNAs are still poorly understood in macrophages, the recent research has displayed promising results [86].…”

Section: Macrophages and Atherosclerosismentioning

confidence: 99%

Dirty Jobs: Macrophages at the Heart of Cardiovascular Disease

Stevens

¹

,

Khalaf

²

,

Soehnlen

³

et al. 2022

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Cardiovascular disease (CVD) is one of the greatest public health concerns and is the leading cause of morbidity and mortality in the United States and worldwide. CVD is a broad yet complex term referring to numerous heart and vascular conditions, all with varying pathologies. Macrophages are one of the key factors in the development of these conditions. Macrophages play diverse roles in the maintenance of cardiovascular homeostasis, and an imbalance of these mechanisms contributes to the development of CVD. In the current review, we provide an in-depth analysis of the diversity of macrophages, their roles in maintaining tissue homeostasis within the heart and vasculature, and the mechanisms through which imbalances in homeostasis may lead to CVD. Through this review, we aim to highlight the potential importance of macrophages in the identification of preventative, diagnostic, and therapeutic strategies for patients with CVD.

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“…Beyond the developments as reviewed in section 2.3, a further level of complexityi.e. the human epigenome and its life-time dynamics in health and cardiovascular disease [84,[146][147][148][149][150][151][152][153][154][155] -emerged as holding promise for possible therapeutic exploitation [114-120, 156, 157]. At the present time, however, the impact of epigenetic drugs upon clinical medicine is still limited as compared to the nucleic acid drugs discussed above.…”

Section: Continuously Emerging New Levels Of Complexity Of the Human ...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

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During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

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“…Beyond the developments as reviewed in section 2.3, a further level of complexity-i.e. the human epigenome and its life-time dynamics in health and cardiovascular disease [84,[145][146][147][148][149][150][151][152][153][154] -emerged as holding promise for possible therapeutic exploitation [114-120, 155, 156]. At the present time, however, the impact of epigenetic drugs upon clinical medicine is still limited as compared to the nucleic acid drugs discussed above.…”

Section: Continuously Emerging New Levels Of Complexity Of the Human ...mentioning

confidence: 99%

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Poller¹,

Heidecker²,

Ammirati³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

During the past few years unexpected developments have driven studies in the field of clinical immunology. One driver of immense impact was the outbreak of a pandemic caused by the novel virus SARS-CoV-2. Excellent recent reviews address diverse aspects of immunological re-search into cardiovascular diseases. Here, we specifically focus on selected studies taking ad-vantage of advanced state-of-the-art molecular genetic methods ranging from genome-wide epi/transcriptome mapping and variant scanning to optogenetics and chemogenetics. First, we discuss emerging clinical relevance of advanced diagnostics for cardiovascular diseases - includ-ing those associated with COVID-19 - with a focus on the role of inflammation in cardiomyopa-thies and arrhythmias. Second, we consider newly identified immunological interactions at or-gan and systems level which affect cardiovascular pathogenesis. Thus, studies into immune in-fluences arising from the intestinal system are moving towards therapeutic exploitation. Fur-ther, powerful new research tools have enabled novel insight into brain – immune system inter-actions at unprecedented resolution. This latter line of investigation emphasizes the strength of influence of emotional stress - acting through defined brain regions - upon viral and cardiovas-cular disorders. Several challenges need to be overcome before the full impact of these far-reaching new findings will hit the clinical arena.

show abstract

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Cited by 123 publications

References 300 publications

Dirty Jobs: Macrophages at the Heart of Cardiovascular Disease

Dirty Jobs: Macrophages at the Heart of Cardiovascular Disease

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

Innate Immunity in Cardiovascular Diseases – Identification of Novel Molecular Players and Targets

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