Epigenetic regulation during melanocyte development and homeostasis

Dilshat, Ramile; Vu, Hong Nhung; Steingrı́msson, Eirı́kur

doi:10.1111/exd.14391

Cited by 11 publications

(5 citation statements)

References 130 publications

(313 reference statements)

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“…CCNB1 may regulate melanocyte proliferation through the p53 signaling pathway [ 82 , 83 ]. In melanocytes, MITF regulates DCT gene expression by forming a protein complex with EP300 [ 84 ]. ADCY10 deletion experiments demonstrated its association with the proliferation of eumelanin [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery

Zhang,

Luosang,

Yuan

et al. 2024

BMC Genomics

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Background Gangba sheep as a famous breed of Tibetan sheep, its wool color is mainly white and black. Gangba wool is economically important as a high-quality raw material for Tibetan blankets and Tibetan serge. However, relatively few studies have been conducted on the wool color of Tibetan sheep. Results To fill this research gap, this study conducted an in-depth analysis of two populations of Gangba sheep (black and white wool color) using whole genome resequencing to identify genetic variation associated with wool color. Utilizing PCA, Genetic Admixture, and N-J Tree analyses, the present study revealed a consistent genetic relationship and structure between black and white wool colored Gangba sheep populations, which is consistent with their breed history. Analysis of selection signatures using multiple methods (FST, π ratio, Tajima's D), 370 candidate genes were screened in the black wool group (GBB vs GBW); among them, MC1R, MLPH, SPIRE2, RAB17, SMARCA4, IRF4, CAV1, USP7, TP53, MYO6, MITF, MC2R, TET2, NF1, JAK1, GABRR1 genes are mainly associated with melanin synthesis, melanin delivery, and distribution. The enrichment results of the candidate genes identified 35 GO entries and 19 KEGG pathways associated with the formation of the black phenotype. 311 candidate genes were screened in the white wool group (GBW vs GBB); among them, REST, POU2F1, ADCY10, CCNB1, EP300, BRD4, GLI3, and SDHA genes were mainly associated with interfering with the differentiation of neural crest cells into melanocytes, affecting the proliferation of melanocytes, and inhibiting melanin synthesis. 31 GO entries and 22 KEGG pathways were associated with the formation of the white phenotype. Conclusions This study provides important information for understanding the genetic mechanism of wool color in Gangba, and provides genetic knowledge for improving and optimizing the wool color of Tibetan sheep. Genetic improvement and selective breeding to produce wool of specific colors can meet the demand for a diversity of wool products in the Tibetan wool textile market.

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Section: Discussionmentioning

confidence: 99%

Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery

Zhang,

Luosang,

Yuan

et al. 2024

BMC Genomics

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“…The role of SOX10 in the life history of adult bulbar melanocytes is also intriguing, given that the expression of this transcription factor is required for melanocyte/melanoblast commitment in utero [ 44 ]. Is SOX10 expression dispensable for some melanocytes in the adult hair bulb?…”

Section: Discussionmentioning

confidence: 99%

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

Casalou

Mayatra

Tobin

2023

IJMS

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The visual appearance of humans is derived significantly from our skin and hair color. While melanin from epidermal melanocytes protects our skin from the damaging effects of ultraviolet radiation, the biological value of pigmentation in the hair follicle, particularly on the scalp, is less clear. In this study, we explore the heterogeneity of pigment cells in the human scalp anagen hair follicle bulb, a site conventionally viewed to be focused solely on pigment production for transfer to the hair shaft. Using c-KIT/CD117 microbeads, we isolated bulbar c-KIT-positive and c-KIT-negative melanocytes. While both subpopulations expressed MITF, only the c-KIT-positive fraction expressed SOX10. We further localized bulbar melanocyte subpopulations (expressing c-KIT, SOX10, MITF, and DCT) that exhibited distinct/variable expression of downstream differentiation-associated melanosome markers (e.g., gp100 and Melan-A). The localization of a second ‘immature’ SOX10 negative melanocyte population, which was c-KIT/MITF double-positive, was identified outside of the melanogenic zone in the most peripheral/proximal matrix. This study describes an approach to purifying human scalp anagen hair bulb melanocytes, allowing us to identify unexpected levels of melanocyte heterogeneity. The function of the more immature melanocytes in this part of the hair follicle remains to be elucidated. Could they be in-transit migratory cells ultimately destined to synthesize melanin, or could they contribute to the hair follicle in non-melanogenic ways?

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“…Melanoblasts originating from embryonic neural crest cells invade the epidermis from the dermis and differentiate into melanocytes. Differentiated epidermal melanocytes migrate into hair follicles and constitute hair bulb melanocytes, where mature stage IV melanosomes are transferred to surrounding keratinocytes, giving rise to melanized hair (4)(5)(6)(7)(8). Melanized hair contributes to the expression of the coat color in animals.…”

Section: Contextmentioning

confidence: 99%

“…Hair bulbs at the bottom of the hair follicles contain keratinocytes, melanocytes, and fibroblasts (special fibroblasts called dermal papillae cells). The hair bulb melanocytes secrete mature melanosomes into surrounding keratinocytes, producing melanized hair (1,(4)(5)(6)(7)(8).…”

Section: Mammalian Melanocyte Developmentmentioning

confidence: 99%

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

Hirobe

2023

J Skin Stem Cell

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Context: Functions of melanocytes are supported by many growth factors and cytokines derived from epidermal and dermal cells, especially keratinocytes and fibroblasts. In addition to these skin cells, elastin fibers are thought to be important for regulating melanocyte functions in normal and abnormal skin. However, the role of elastin has not been fully investigated. Recently, the research on the role of elastin in melanocyte functions has greatly increased even in human skin, whereas no full review article on this subject has been presented so far. Thus, the author tried to present a complete review article on this subject in animals and humans. Methods: The author searched the literature on elastin and melanocytes in research databases. Results: Elastin fibers can affect the normal functions of melanoblasts/melanocytes in animals and humans. Moreover, elastin fibers influence melanocyte functions in abnormal skin. In vitiliginous skin, where melanin and melanoblasts/melanocytes are completely lost, elastin fibers are dramatically reduced. However, elastin fibers are completely restored or even increased in the dermis of repigmented skin after phototherapy and/or skin transplantation. Moreover, elastin fibers penetrate the basement membrane of repigmented skin, suggesting a direct contact between dermal elastin fibers and epidermal melanoblasts/melanocytes. Conclusions: Elastin/elastin fibers may control the functions of mammalian melanocytes in normal and abnormal skin.

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Epigenetic regulation during melanocyte development and homeostasis

Cited by 11 publications

References 130 publications

Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery

Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin

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