Epigenetic programming of host lipid metabolism associates with resistance to TST/IGRA conversion after exposure toMycobacterium tuberculosis
Kimberly A Dill-McFarland,
Jason D Simmons,
Glenna J Peterson
et al.
Abstract:Mycobacterium tuberculosis(Mtb) exposure leads to a range of outcomes including clearance, latent TB infection (LTBI), and pulmonary tuberculosis (TB). Some heavily exposed individuals resist tuberculin skin test (TST) and interferon gamma release assay (IGRA) conversion (RSTR), which suggests that they employ IFNγ-independent mechanisms of Mtb control. Here, we compare monocyte epigenetic profiles of RSTR and LTBI from a Ugandan household contact cohort. Chromatin accessibility did not differ between uninfect… Show more
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