Epigenetic predictors of species maximum life span and other life-history traits in mammals
Caesar Z. Li,
Amin Haghani,
Qi Yan
et al.
Abstract:By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (
R
= 0.89), gestation time (
R
= 0.96), and age at sexual maturity (
R
= 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric restriction or partial repro… Show more
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