Epigenetic MRI: Noninvasive imaging of DNA methylation in the brain

Abstract

Significance Dynamic epigenetic activity is a fundamental mechanism underpinning how the brain changes its function during development and aging and in response to environmental and disease stimuli. We developed a technology called epigenetic MRI (eMRI) that enables noninvasive imaging of DNA methylation in the brain, a major epigenetic mechanism. eMRI reveals strong regional differences in global DNA methylation in pig brains, a model with stronger resemblance to human brains than are rodents. Given the noninvasive nature of eMRI, our results pave the way for a DNA-methylation imaging paradigm for living human brains. We expect eMRI to enable many studies to unravel the molecular control of brain function and disease.

Fabrication of magnetic nanoprobes for ultrahigh-field magnetic resonance imaging

“…, enzymes, reductive molecules, and reactive nitrogen species). 67,84,85,104 For instance, enzymes are involved in a variety of human diseases and are frequently targets for drug delivery and diagnosis. 105 Therefore, the sensitive detection and imaging of enzyme activity in living organisms is one of the ultimate goals of bioimaging.…”