Epigenetic modulator UVI5008 inhibits MRSA by interfering with bacterial gyrase

Franci, Gianluigi; Cammarota, Marcella; Zannella, Carla; Sarno, Federica; Schiraldi, Chiara; Lera, Ángel R. de; Altucci, Lucia; Galdiero, Massimiliano

doi:10.1038/s41598-018-31135-9

Cited by 28 publications

(29 citation statements)

References 37 publications

(41 reference statements)

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“…Nowadays, the growing threat of microbial resistance against traditional antibiotics in oral disease has prompted the mandatory development of alternative therapies, especially against bacterial strains showing resistance to one or more antibiotics [60,61]. In this article, silver NPs (AgNPs) were successfully prepared using hydrazine and were further modified by a coating of indolicidin, a well-known AMP.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

et al. 2020

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Featured Application: Indolicidin-coated silver nanoparticles could be used as platforms in the dental field as oral disease preventive drug. Furthermore, nanomaterials could prevent oral cancers and balance oral health care. Abstract:(1) Background: In dentistry, silver nanoparticles (AgNPs) have progressively earned great interest as antimicrobial drugs and are widely used in several biomedical fields. Recent progress in the analysis of complex bacterial communities has demonstrated the richness of the oral microbiota and the presence of numerous previously unexplained strains. Several efforts have been dedicated to the investigation of antimicrobial peptides (AMPs). Those peptides are a widespread group of small peptides against invading microbes. We report the production of a hybrid molecule composed of AgNPs and indolicidin, a well-known antibacterial peptide. (2) Methods: Spectroscopy and microscopy were used to analyze the optical features and to determine the size of the generated AgNPs. The AgNP antibacterial activity was evaluated versus oral Gram-positive and Gram-negative bacteria.(3) Results: The coated nanoparticles' antibacterial activity strongly inhibited the growth of microorganisms, with very low minimum inhibitory concentration (MIC) values in the range of 5-12.5 µg/mL. We hypothesize that this effect depended on the specific characteristics of the metal surface coated with indolicidin. The second result was that the coated nanoparticles observed cellular toxicity, was lower with respect to the toxicity of peptide and the naked AgNPs when used individually. (4) New investigations regarding antimicrobial effect of AgNPs coated with AMPs in oral infections are an urgent task.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

et al. 2020

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“…e Gramnegative and -positive isolated bacteria in our University Hospital had shown a low rate of resistance to the fluoroquinolones tested (ciprofloxacin, moxifloxacin, and levofloxacin). Antibiotics, belonging to this class, inhibit DNA gyrase and topoisomerase IV, enzymes that are involved in DNA replication [39]. ese drugs are broad-spectrum antibiotics, providing excellent coverage against most ocular pathogens [40].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antibiotic Resistance Patterns of Ocular Bacterial Strains Isolated from Pediatric Patients in University Hospital of Campania “Luigi Vanvitelli,” Naples, Italy

Petrillo

Folliero

Santella

et al. 2020

International Journal of Microbiology

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Eye infections caused by bacteria are a serious public health problem among pediatric patients. These diseases, if not properly treated, can cause blindness and impaired vision. The study aimed to evaluate the antimicrobial resistance profiles of the main pathogens involved in eye infections. This study involved pediatric patients enrolled at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2019. Of a total of 228 pediatric patients, 73 (32%) tested positive for bacterial infection. In terms of strain distribution, 85% were Gram-positive bacteria, while 15% were Gram-negative bacteria. The most frequently isolated strains were coagulase-negative Staphylococci (60.4%), followed by Staphylococcus aureus (16.4%). The isolated bacteria showed a significant percentage of resistance to multiple antibiotics. Therefore, the identification of the causal bacteria and antimicrobial sensitivity tests are mandatory to select the effective drug for the treatment of eye infections and prevent the development of antibiotic-resistant bacteria.

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“…Epigenetic regulations refer to the complex and multilayered mechanisms involved in the variation of a gene expression without a change in the DNA sequence itself [ 92 ]. Epigenetics represents a pivotal mechanism of cellular and organ homeostasis, which includes various regulatory events, such as DNA methylation, histone modifications and noncoding RNAs [ 93 , 94 ].…”

Section: Daas Treatment and Hcc Fate Under The Light Spot Of Epigementioning

confidence: 99%

Risk of Hepatocellular Carcinoma after HCV Clearance by Direct-Acting Antivirals Treatment Predictive Factors and Role of Epigenetics

Rinaldi

Nevola

Franci

et al. 2020

Cancers

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Direct-acting antivirals (DAAs) induce a rapid virologic response (SVR) in up to 99% of chronic hepatitis C patients. The role of SVR by DAAs on the incidence or recurrence of hepatocellular carcinoma (HCC) is still a matter of debate, although it is known that SVR does not eliminate the risk of HCC. In this review, we made an updated analysis of the literature data on the impact of SVR by DAAs on the risk of HCC as well as an assessment of risk factors and the role of epigenetics. Data showed that SVR has no impact on the occurrence of HCC in the short–medium term but reduces the risk of HCC in the medium–long term. A direct role of DAAs in the development of HCC has not been demonstrated, while the hypothesis of a reduction in immune surveillance in response to the rapid clearance of HCV and changes in the cytokine pattern influencing early carcinogenesis remains to be further elucidated. HCV induces epigenetic alterations such as modifications of the histone tail and DNA methylation, which are risk factors for HCC, and such changes are maintained after HCV clearance. Future epigenetic studies could lead to identify useful biomarkers and therapeutic targets. Cirrhosis has been identified as a risk factor for HCC, particularly if associated with high liver stiffness and α-fetoprotein values, diabetes and the male sex. Currently, considering the high number and health cost to follow subjects’ post-HCV clearance by DAAs, it is mandatory to identify those at high risk of HCC to optimize management.

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Epigenetic modulator UVI5008 inhibits MRSA by interfering with bacterial gyrase

Cited by 28 publications

References 37 publications

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

Antibacterial Activity of Indolicidin-Coated Silver Nanoparticles in Oral Disease

Prevalence and Antibiotic Resistance Patterns of Ocular Bacterial Strains Isolated from Pediatric Patients in University Hospital of Campania “Luigi Vanvitelli,” Naples, Italy

Risk of Hepatocellular Carcinoma after HCV Clearance by Direct-Acting Antivirals Treatment Predictive Factors and Role of Epigenetics

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