Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals

Zhang, Naifeng

doi:10.1016/j.aninu.2015.09.002

Cited by 112 publications

(97 citation statements)

References 122 publications

(150 reference statements)

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“…As abovementioned, an increasing number of studies in rodents have demonstrated that the nutritional stimuli may alter the phenotype of animals through epigenetic mechanisms [48] as well as these epigenetic alterations can be transmitted through at least three generations in mammals [49]. Here, we found a higher degree of global 5-mC and a diminution in 5-hmC, which paralleled with changes in their enzymatic machinery such as DNMTs and TETs, in the hippocampus of the offspring.…”

Section: Discussionsupporting

confidence: 67%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

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A variety of environmental factors contribute significantly to age-related cognitive decline and Alzheimer’s Disease (AD). Nutrition can alter epigenetics, improving health outcomes, which transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in offspring. We feed females SAMP8 with resveratrol-enriched diet during two months prior to mating. Direct exposed F1 generation and the transgenerational F2 generation were investigated. Object novel recognition and Morris water maze demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring resulted from resveratrol fed mother showed increase AMPKα activation, mTOR inhibition and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways.

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Section: Discussionsupporting

confidence: 67%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

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“…Supplementation with methyl donors including FA has been reported to alleviate the effects of adverse intrauterine environment [25]. In only a few studies, however, DNA methylation status has been examined.…”

Section: Plos Onementioning

confidence: 99%

Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney

Awazu

Hida

2020

PLoS ONE

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We previously reported that maternal nutrient restriction (NR) inhibited ureteric branching, metanephric growth, and nephrogenesis in the rat. Here we examined whether folic acid, a methyl-group donor, rescues the inhibition of kidney development induced by NR and whether DNA methylation is involved in it. The offspring of dams given food ad libitum (CON) and those subjected to 50% food restriction (NR) were examined. NR significantly reduced ureteric tip number at embryonic day 14, which was attenuated by folic acid supplementation to nutrient restricted dams. At embryonic day 18, glomerular number, kidney weight, and global DNA methylation were reduced by NR, and maternal folic acid supplementation again alleviated them. Among DNA methyltransferases (DNMTs), DNMT1 was strongly expressed at embryonic day 15 in CON but was reduced in NR. In organ culture, an inhibitor of DNA methylation 5-aza-2 '-deoxycytidine as well as medium lacking methyl donors folic acid, choline, and methionine, significantly decreased ureteric tip number and kidney size mimicking the effect of NR. In conclusion, global DNA methylation is necessary for normal kidney development. Folic acid supplementation to nutrient restricted dams alleviated the impaired kidney development and DNA methylation in the offspring.

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“…Evidences showing a link between early life nutrition and epigenetics have been shown and reviewed by several authors (Dolinoy et al 2006;Kucharski et al 2008;Vickers 2014;Zhang 2015;Marandel et al 2016). This knowledge can be extremely useful for aquaculture, where feeding plays a major role for a sustainable production.…”

Section: Epigenetics In Aquaculturementioning

confidence: 98%

Epigenetics in aquaculture – the last frontier

Granada

Lemos

Cabral

et al. 2017

Reviews in Aquaculture

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Aquaculture production is expanding rapidly around the world. To tackle rising production and species diversity issues, innovations in the field of aquaculture feeds, breeding, disease management and other improvements must be addressed. In this framework, the study of epigenetic mechanisms behind different aquaculture rearing processes presents great opportunities. The transcriptional impact of epigenetic modifications, triggered by environmental stimuli, has been shown to influence the organism's phenotype. Therefore, understanding the environmental‐induced epigenetic markers related to disease resistance or other economically important traits will allow the establishment of favourable breeding conditions with increased economical revenue. Several studies have shown epigenetic effects in various species, induced by different rearing conditions, with benefits for the organisms and evidences for heritability of the acquired adaptive phenotypic traits across generations, making these studies even more relevant in a production context. These studies have demonstrated the great potential of epigenetics to positively induce disease resistance, stress tolerance and attain better sex ratios in the aquatic organism. Also, in the field of nutritional epigenetics, the possibility of early nutritional programming to improve the performance of broodstock or even the long‐term performance of their progeny has been suggested. In sum, an increased understanding of epigenetic mechanisms in economically important species, and the epigenetic markers leading to the most favourable phenotypic traits, will contribute to the expansion of economically viable commercial aquaculture industries. The major epigenetic mechanisms and respective analysis methods, as well as the state of the art and potential applications in aquaculture, are addressed in this review.

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Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals

Cited by 112 publications

References 122 publications

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney

Epigenetics in aquaculture – the last frontier

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