Epigenetic modification: possible approach to reduce<i>Salmonella enterica</i>serovar enteritidis susceptibility under stress conditions

Soleimani, A. F.; Zulkifli, I.; Hair-Bejo, M.; Ebrahimi, Mahdi; Jazayeri, Seyed Davoud; Hashemi, Seyed Reza; Meimandipour, Amir; Goh, Yong Meng

doi:10.1080/03079457.2012.691155

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…Environmental stressors were shown to negatively affect a bird's immune system, compromising its performance and ability to overcome bacterial infections (Humphrey, 2006;Dunkley et al, 2007;Burkholder et al, 2008;QuinteiroFilho et al, 2012a;Soleimani et al, 2012). We showed that heat stress (31°C and 36°C for 35 to 42 days) decreased performance parameters and macrophage activity and induced intestinal injury; these effects were attributed to hypothalamic-pituitary-adrenal (HPA) axis activation.…”

Section: Introductionmentioning

confidence: 87%

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

et al. 2014

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Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyse the effects from overcrowding stress of 16 birds/m 2 on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The results of this study indicate that overcrowding stress decreased performance parameters, induced enteritis and decreased macrophage activity and the relative bursa weight in broiler chickens. When the chickens were similarly stressed and infected with Salmonella Enteritidis, there was an increase in feed conversion and a decrease in plasma IgG levels in the stressed and Salmonella-infected birds. We observed moderate enteritis throughout the duodenum of chickens stressed and infected with Salmonella. The overcrowding stress decreased the macrophage phagocytosis intensity and increased Salmonella Enteritidis counts in the livers of birds challenged with the pathogenic bacterium. Overcrowding stress via the hypothalamic-pituitary-adrenal axis that is associated with an increase in corticosterone and enteritis might influence the quality of the intestinal immune barrier and the integrity of the small intestine. This effect allowed pathogenic bacteria to migrate through the intestinal mucosa, resulting in inflammatory infiltration and decreased nutrient absorption. The data strengthen the hypothesis that control of the welfare of chickens and avoidance of stress from overcrowding in poultry production are relevant factors for the maintenance of intestinal integrity, performance and decreased susceptibility to Salmonella infection.

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Section: Introductionmentioning

confidence: 87%

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

et al. 2014

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“…For this purpose, two different environmental farm conditions, commercial farm conditions (CFC) (house 1) and optimal farm conditions (OFC) (house 2), were evaluated. For CFC, chicks were housed at 35 kg/m 2 density, and non‐optimal parameters of ventilation were applied (allowing a maximum concentration of ammonia of 25 ppm). While in OFC, the animals were housed in low density at 17 kg/m 2 , and ventilation was provided within the optimal parameters (allowing a maximum concentration of ammonia of 10 ppm).…”

Section: Methodsmentioning

confidence: 99%

“…Animal welfare and food safety are increasing concerns for poultry product consumers 1 . Both issues are closely related, as it has been demonstrated that if animals are in good welfare status, their resilience is increased, and they can cope with environmental challenges or infectious diseases 2–5 . For that reason, an investment in more efficient and animal friendly management measures in the poultry sector could directly affect animal health 3,6–9 .…”

Section: Introductionmentioning

confidence: 99%

Influence of farm management on the dynamics of Salmonella enterica serovar Infantis shedding and antibiotic resistance during the growing period of broiler chickens

et al. 2021

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Background: Salmonella enterica serovar Infantis is a zoonotic pathogen isolated in broilers causing great economic losses in the European poultry sector. It is demonstrated that an investment in management measures at farm level could directly affect the control of food chain microorganisms. The aim of this study was to investigate the development of S. Infantis antimicrobial resistance (AMR) patterns during the growing period, according to flock density and ventilation management, without antibiotic administration. Methods: The experiment was performed in two identical poultry houses, evaluating commercial and optimal farm conditions. At 24 h of rearing, 20% of the animals were orally infected with a S. Infantis strain susceptible to all the antibiotics tested. To study Salmonella shedding, faeces samples from each experimental group were taken weekly and analysed as per ISO/TS 6579-2:2017. Antibiotic susceptibility was assessed according to Decision 2013/653. Results: Salmonella shedding showed that the lowest counts were observed in the first week post-infection and highest at slaughter day for both groups. Moreover, 100% of the isolates were multi-resistant. Conclusion:The acquisition of AMR by S. Infantis starts at the onset of the production cycle and is maintained until the end, demonstrating the importance of transmission of AMR in zoonotic bacteria at farm level.

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“…Environmental stressors were shown to negatively affect a bird's immune system, compromising its performance and ability to overcome bacterial infections (Humphrey, 2006;Dunkley et al, 2007;Burkholder et al, 2008;Quinteiro-Filho et al, 2012a;Soleimani et al, 2012). We showed that heat stress (31°C and 36°C for 35 to 42 days) decreased performance parameters and macrophage activity and induced intestinal injury; these effects were attributed to hypothalamic-pituitary-adrenal (HPA) axis activation.…”

Section: Introductionmentioning

confidence: 99%

104. Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens

Palermo-Neto

Quinteiro-Filho

Ribeiro

et al. 2014

Brain, Behavior, and Immunity

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vaccine experimental inflammation model together with computational modelling of an instrumental learning task performed during fMRI (1). Twenty-two healthy participants were each tested 3-h after blindly administered typhoid vaccine (0.025 mg) and placebo (0.5 ml 0.9% NaCl) injection. Typhoid but not placebo was associated with a threefold increase in plasma IL-6 (t(21) = 5.20, p < 0.001) confirming induction of mild inflammation. Following inflammation participants demonstrated greater avoidance of a punishing cue (loss £1) and significantly reduced selection of a rewarded cue F(21,1) = 6.41, p = 0.019. Computational modelling of individuals' choices using a Q-learning model (free parameters alpha (learningrate), beta (choice-randomness) and R (reward value)) demonstrated significant reduction in reward cue value and increase in value of punishment cues following inflammation F(21,1) = 3.63, p < 0.05. fMRI confirmed previous correlations of appetitive and aversive prediction error (PE) within ventral striatal (VS) and anterior insula (AI) regions of interest respectively (FWE p < 0.05) across conditions. However, inflammation significantly impaired VS responses to appetitive PE and enhanced AI responses to aversive PE (FWE p < 0.05) suggesting that inflammation modulates the value of aversive and appetitive cues via actions on VS and AI prediction error signals respectively. (1) Pessiglione et al., 2006. Nature 442, 1042-45. http://dx.Despite decades of progress, the biological mechanisms underlying addiction are unknown. Glia, including astrocytes and microglia, profoundly influence neuronal function and may play a critical role in the development of drug addiction. Previously, we have shown that a neonatal handling procedure (which promotes enriched maternal care) reduces glial activation to an acute morphine challenge and prevents reinstatement of morphine conditioned place preference; likewise, similar results were obtained by pharmacological manipulation of glia within the nucleus accumbens (NAc). Here, we investigated the effects of opioid self-administration on central immune signaling within the NAc and its modulation by early-life experience. Male rat pups were handled (15 min/day) from postnatal day (P) 2 to P20 or left undisturbed. In adulthood, all rats were tested for self-administration of intravenous remifentanil (a short-acting opioid) in daily 1 h sessions for 2 weeks. Brains were then collected to examine persistent alterations in glial activation. Neonatal handling reduced acquisition of remifentanil; this effect was specific for opioids, as acquisition of food reward was unaffected. Remifentanil self-administration substantially increased glial antigen expression (Iba1 and GFAP) and proinflammatory gene expression in NAc, including the innate immune receptor TLR4. However, only handled rats showed increased expression of the anti-inflammatory cytokine IL-10. These data establish neural-glial interactions in the NAc as an essential component of self-motivated drug acquisition that can be alte...

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Epigenetic modification: possible approach to reduceSalmonella entericaserovar enteritidis susceptibility under stress conditions

Cited by 10 publications

References 25 publications

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

Overcrowding stress decreases macrophage activity and increasesSalmonellaEnteritidis invasion in broiler chickens

Influence of farm management on the dynamics of Salmonella enterica serovar Infantis shedding and antibiotic resistance during the growing period of broiler chickens

104. Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens

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