Epigenetic modification of &lt;i&gt;Kiss1&lt;/i&gt; gene expression in the AVPV is essential for female reproductive aging

Dai, Ruoxi; Wen, Xu; Chen, Wei; Cui, Lianxian; Li, Lisha; Zhou, Jing; Jin, Xueling; Wang, Yan; Sun, Yan

doi:10.5582/bst.2022.01358

Cited by 6 publications

(2 citation statements)

References 63 publications

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“…Paraffin blocks of skin samples were used to obtain 4-μm sections, which were used for immunofluorescence and fluorescence in situ hybridization as previously described ( 91 ). Antibodies used for immunofluorescence were anti-cytokeratin 10 (rabbit, Servicebio, Cat# GB112105-100), anti-cytokeratin 14 (rabbit, Abcam, Cat# ab119695), anti-ID1 (mouse, Santa Cruz, Cat# sc-133104), and anti-aquaporin 3 (rabbit, Servicebio, Cat# GB11395-100).…”

Section: Methodsmentioning

confidence: 99%

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

Chen,

Dragan,

Sun

et al. 2024

Preprint

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Skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors and regulates barrier robustness and immune homeostasis. AhR agonist is in clinical trial for atopic dermatitis (AD) treatment, but the underlying mechanism of action remains ill-defined. Here we reportOVOL1/Ovol1as a conserved and direct transcriptional target of AhR in epidermal keratinocytes. We show that OVOL1/Ovol1 impacts AhR regulation of keratinocyte gene expression, andOvol1deletion in keratinocytes hampers AhR’s barrier promotion function and worsens AD-like inflammation. Mechanistically, we identify Ovol1’s direct downstream targets genome-wide, and providein vivoevidence for Id1’s critical role in barrier maintenance and disease suppression. Furthermore, our findings reveal an IL-1/dermal γδT cell axis exacerbating both type 2 and type 3 immune responses downstream of barrier perturbation inOvol1-deficient AD skin. Finally, we present data suggesting the clinical relevance of OVOL1 and ID1 function in human AD. Our study highlights a keratinocyte-intrinsic AhR-Ovol1-Id1 regulatory axis that promotes both epidermal and immune homeostasis against AD-like inflammation, implicating new therapeutic targets for AD.

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Section: Methodsmentioning

confidence: 99%

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

Chen,

Dragan,

Sun

et al. 2024

Preprint

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“…Половые различия могут быть обусловлены взаимодействием ингибитора HDAC с гормонами, регулирующими размножение и развитие организма. Например, в исследованиях на грызунах описана обратная связь между эпигенетическими модификациями и половыми гормонами (эстрадиолом и лютеинизирующим гормоном), которая определяет состояние здоровье и старение [67,68]. Также установлено, что ацетилирование и деацетилирование гистонов важны для регуляторной активности ювенильного гормона у дрозофилы, а трихостатин А способен влиять на экспрессию ряда генов, опосредующих действие этого гормона [69].…”

Section: изменение экспрессии генов стресс-ответа у дрозофил после об...unclassified

Investigation of geroprotective and radioprotective effects of berberine and trichostatin A on the model of Drosophila melanogaster

Ulyasheva,

Proshkina,

Shaposhnikov

et al. 2023

Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences

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The search for drugs that slow down the rate of aging and stimulate radioresistance is an urgent task of biology, ecology, and medicine. In this work we have studied the effects of trichostatin A and berberine on the lifespan, resistance to the paraquat prooxidant and acute gamma irradiation of the Drosophila melanogaster fruit fly. Trichostatin A demonstrated a better geroprotective effect, increasing the Drosophila lifespan by 3-9 %. However, an increase in radioresistance was observed only after the application of berberine in males. Their median survival after gamma irradiation increased by 25 %. Trichostatin A, on the contrary, increased the sensitivity of flies to gamma irradiation genotoxic effects, reducing the survival by 7-17 %.

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Multiomics insights into the female reproductive aging

Wei,

Tang,

Chen

et al. 2024

Ageing Research Reviews

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Epigenetic modification of <i>Kiss1</i> gene expression in the AVPV is essential for female reproductive aging

Cited by 6 publications

References 63 publications

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

Investigation of geroprotective and radioprotective effects of berberine and trichostatin A on the model of Drosophila melanogaster

Multiomics insights into the female reproductive aging

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