Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype

Fritz, Andrew J.; Dika, Mohammed El; Toor, Rabail H; Rodriguez, Princess D.; Foley, Stephen J; Ullah, Rahim; Nie, Daijing; Banerjee, Bodhisattwa; Lohese, Dorcas; Tracy, Kirsten M.; Glass, Karen C.; Frietze, Seth; Ghule, Prachi N.; Heath, Jessica L.; Wijnen, André van; Gordon, Jonathan A. R.; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.

doi:10.1007/978-3-031-06573-6_12

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

2022

DOI: 10.1007/978-3-031-06573-6_12

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Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype

Andrew J. Fritz

Mohammed El Dika

Rabail H Toor

et al.

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2024

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The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression

Ivanov,

Yang,

Sun

et al. 2024

FEMS Microbiology Reviews

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Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes widespread changes in epigenetic modifications and chromatin architecture in the host cell. Recent evidence suggests that SARS-CoV-2 nonstructural protein 1 (nsp1) plays an important role in driving these changes. Previously thought to be primarily involved in host translation shutoff and cellular mRNA degradation, nsp1 has now been shown to be a truly multifunctional protein that affects host gene expression at multiple levels. The functions of nsp1 are surprisingly diverse and include not only the downregulation of cellular mRNA translation and stability, but also the inhibition of mRNA export from the nucleus, the suppression of host immune signaling, and, most recently, the epigenetic regulation of host gene expression. In this review, we first summarize the current knowledge on SARS-CoV-2-induced changes in epigenetic modifications and chromatin structure. We then focus on the role of nsp1 in epigenetic reprogramming, with a particular emphasis on the silencing of immune-related genes. Finally, we discuss potential molecular mechanisms underlying the epigenetic functions of nsp1 based on evidence from SARS-CoV-2 interactome studies.

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The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression

Ivanov,

Yang,

Sun

et al. 2024

FEMS Microbiology Reviews

View full text Add to dashboard Cite

show abstract

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Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype

Cited by 1 publication

References 437 publications

The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression

The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression

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