Epigenetic mechanisms regulate cue memory underlying discriminative behavior

Shang, Andrea; Bieszczad, Kasia M.

doi:10.1016/j.neubiorev.2022.104811

Cited by 7 publications

(3 citation statements)

References 162 publications

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“…Previous studies have revealed that butyrate can improve memory in mouse models presenting with Alzheimer's disease (AD) (Govindarajan et al ., 2011 ). Additionally, numerous studies have documented that the blockage of histone deacetylases (HDACs) could enhance memory encoding and demonstrate a favorable effect over the biological expression of synaptic plasticity genes (Bieszczad et al ., 2015 ; Shang and Bieszczad, 2022 ). Recently, a study using obese mouse models reported that cognitive decline can be induced by quinolinic acid.…”

Section: Gut Microbiota-derived Metabolites and Brain Healthmentioning

confidence: 99%

Microbiota–gut–brain axis: the mediator of exercise and brain health

Kang,

Wang

2024

Psychoradiology

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The human brain is the command center for the nervous system enabling thoughts, memory, movement, and emotions through a complex function. The Microbiota-gut-brain axis is a bidirectional neural, hormonal, and immune signaling pathway that could link the gastrointestinal tract to the brain. Over the past few decades, the gut microbiota has been demonstrated to be an essential component of the gastrointestinal tract that plays a crucial role in regulating most functions of various body organs. The effects of the microbiota on the brain occur through the production of neurotransmitters, hormones, and metabolites, regulation of host-produced metabolites, or through the synthesis of metabolites by the microbiota themselves. This affects the host's behavior, mood, attention state, and the brain's food reward system. Meanwhile, there is an intimate association between the gut microbiota and exercise. Exercise has the capacity to alter the diversity of gut microbiota both quantitatively and qualitatively, which may be partially responsible for the widespread benefits of regular physical activity on human health. Functional magnetic resonance imaging (fMRI) is a non-invasive method to show areas of brain activity, fMRI enables the delineation of specific brain regions involved in neurocognitive disorders. Through combining exercise tasks and fMRI techniques, researchers can observe the effects of exercise on higher brain functions such as anxiety disorders, depression, cognitive function, and food reward. However, there has been limited evidence regarding the complex nexus between gut microbiota, exercise, and brain health, specifically in how exercise impacts brain health through gut microbiota. This article reviews and highlights the connections between microbiota-derived metabolites, exercise, and brain health. An in-depth study of these three interactions will help us to further understand the positive effects of exercise on brain health and provide new strategies and approaches for the prevention and treatment of brain diseases.

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Section: Gut Microbiota-derived Metabolites and Brain Healthmentioning

confidence: 99%

Microbiota–gut–brain axis: the mediator of exercise and brain health

Kang,

Wang

2024

Psychoradiology

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show abstract

“…Various studies have suggested that cognitive and motor deficits occur in aging rodents, apart from dysregulation of epigenetics during learning and memory processes, which has been associated with AD pathogenesis (61)(62)(63). The effect of epigenetic processes on learning and memory extends to the sensory system, where all core cue-evoking processes dependent on experience begin in the brain (64). Moreover, stress, fear, and anxiety-like behaviors have been associated with neurodegeneration, aging, and AD (62,65,66).…”

Section: Learning and Memory Testing Of The Micementioning

confidence: 99%

Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice

et al. 2023

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Healthcare is an emerging industry with significant market potential in the 21st century. Therefore, this study aimed to evaluate the benefits of tube feeding Huáng qí and its complexes for 8 weeks on 3-month-old senescence-accelerated mouse prone-8 (SAMP8) mice, 48 in total, randomly divided into 3 groups including control, Huáng qí extract [820 mg/kg Body weight (BW)/day], and Huáng qí complexes (6.2 mL /kg BW/day), where each group consisted of males (n = 8) and females (n = 8). Behavioral tests (locomotion test and aging score assessment on week 6, the single-trial passive avoidance test on week 7, and the active shuttle avoidance test on week 8) were conducted to evaluate the ability of the mice to learn and remember. In addition, after sacrificing the animals, the blood and organs were measured for antioxidant and aging bioactivities, including malondialdehyde (MDA) content and superoxide dismutase (SOD) activity and catalase activities (CAT), and the effects on promoting aging in SAMP8 mice were investigated. The findings showed that Huáng qí enhanced locomotor performance and had anti-aging effects, with positive effects on health, learning, and memory in SAMP-8 mice (p < 0.05), whether applied as a single agent (820 mg/kg BW/day) or as a complex (6.2 mL/kg BW/day) (p < 0.05). Based on existing strengths, a more compelling platform for clinical validation of human clinical evidence will be established to enhance the development and value-added of astragalus-related products while meeting the diversified needs of the functional food market.

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“…Moreover, the Bdnf mRNA isoform containing the 5′ exon IV displays activity-dependent transcription much like an immediate early gene [ 42 ], and this isoform is associated with sensory cortex expression [ 33 , 43 ]. In addition, epigenetic modifications to Bdnf 's exon IV promoter region arise during learning and extinction processes in the cortex [ 44 , 45 ], and such neuroepigenetic mechanisms for plasticity are increasingly being investigated within sensory cortex [ 46 ]. Finally, its gene contains an estrogen response element that could make it susceptible to hormonal modulation [ 47 ].…”

Section: Introductionmentioning

confidence: 99%

Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex

et al. 2023

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While infant cues are often assumed to innately motivate maternal response, recent research highlights how the neural coding of infant cues is altered through maternal care. Infant vocalizations are important social signals for caregivers, and evidence from mice suggests that experience caring for mouse pups induces inhibitory plasticity in the auditory cortex (AC), though the molecular mediators for such AC plasticity during the initial pup experience are not well delineated. Here, we used the maternal mouse communication model to explore whether transcription in AC of a specific, inhibition-linked, memory-associated gene, brain-derived neurotrophic factor (Bdnf) changes due to the very first pup caring experience hearing vocalizations, while controlling for the systemic influence of the hormone estrogen. Ovariectomized and estradiol or blank-implanted virgin female mice hearing pup calls with pups present had significantly higher AC exon IV Bdnf mRNA compared to females without pups present, suggesting that the social context of vocalizations induces immediate molecular changes at the site of auditory cortical processing. E2 influenced the rate of maternal behavior but did not significantly affect Bdnf mRNA transcription in the AC. To our knowledge, this is the first time Bdnf has been associated with processing social vocalizations in the AC, and our results suggest that it is a potential molecular component responsible for enhancing future recognition of infant cues by contributing to AC plasticity.

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Epigenetic mechanisms regulate cue memory underlying discriminative behavior

Cited by 7 publications

References 162 publications

Microbiota–gut–brain axis: the mediator of exercise and brain health

Microbiota–gut–brain axis: the mediator of exercise and brain health

Potential antidepressant effects of a dietary supplement from Huáng qí and its complex in aged senescence-accelerated mouse prone-8 mice

Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex

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