“…Also, symptoms of depression are present in a significant proportion of Alzheimer’s disease patients (Cerejeira et al, 2012). While, pathophysiology of depression remains poorly understood, aberrant epigenetic regulation of gene transcription has been suggested in patients with major depression as well as in animal models of depression (Consortium, 2015; Robison and Nestler, 2011; Sun et al, 2013; Uchida et al, 2017b). Several of the activity-dependent transcription factors and cofactors have been associated with depression, including CREB (Carlezon et al, 2005), MeCP2 (Hutchinson et al, 2012; Uchida et al, 2011) and CRTC1 (Meylan et al, 2016a; Meylan et al, 2016b).…”