Epigenetic Mechanisms of Integrative Medicine

Kanherkar, Riya R.; Stair, Susan E.; Bhatia‐Dey, Naina; Mills, Paul J.; Chopra, Deepak; Csóka, Antonei B.

doi:10.1155/2017/4365429

Cited by 37 publications

(22 citation statements)

References 123 publications

(151 reference statements)

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“…These studies may provide evidence for the influence of EA on alterations of epigenetic and gene change. Qi is considered as the basis of acupuncture and is called an energy force traveling throughout our body along “meridians” or special pathways [ 29 ]. The meridians come to the specific surface of the skin where they are considered as acupuncture points.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Reduces Weight in Diet‐Induced Obese Rats via Hypothalamic Tsc1 Promoter Demethylation and Inhibition of the Activity of mTORC1 Signaling Pathway

Jincheng

Xiong

Yao

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Subject The study aimed to investigate the mechanism of electroacupuncture reducing weight via tuberous sclerosis complex 1 (Tsc1) promoter methylation, inhibiting the mammalian target of rapamycin complex 1 (mTORC1) pathway. Materials and Methods Male Sprague-Dawley rats were divided into chow-fed group (chow group) or high-fat diet group (HF group) for 14 weeks. The obesity rats in HF group were randomly divided into electroacupuncture group (EA group) and diet-induced obesity (DIO) group, which received EA stimulation on bilateral ST25, RN12, SP6, and ST36 for 4 weeks or no further treatment, respectively. Methylation of the Tsc1 gene promoter and expression of agouti-related protein (AgRP), neuropeptide Y (NPY), and proopiomelanocortin (PoMC) were detected at the 18th week. Results At week 18, weight, body fat, and the body fat rate in DIO group were significantly higher than those of the chow and EA group. Compared with the chow group, the DIO group had increased methylation of the Tsc1 gene promoter and expression of mTORC1, AgRP, and NPY gene and decreased PoMC in the hypothalamus; after EA, methylation of the Tsc1 gene promoter, mRNA, and protein of the mTORC1 and expression of AgRP and NPY gene decreased and PoMC increased significantly. Conclusions Our study could shed light on the potential pathway where EA exerts effects on the mechanism of EA treatment for obesity through the hypothalamic Tsc1 promoter demethylation and inhibition of the activity of mTORC1 signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Electroacupuncture Reduces Weight in Diet‐Induced Obese Rats via Hypothalamic Tsc1 Promoter Demethylation and Inhibition of the Activity of mTORC1 Signaling Pathway

Jincheng

Xiong

Yao

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…We would emphasise that the empirical basis for theoretical development is of primary importance. More extreme claims have been made for 'epigenetic supplements', or defences of pseudoscientific theories such as homoeopathy (Kanherkar et al 2017), but here solid empirical evidence is to-date highly questionable.…”

Section: Critical Reflection: Objections To Our Approachmentioning

confidence: 99%

Covid-19 and the Epigenetics of Learning

2020

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Covid-19 is a natural phenomenon that has rapidly upended much of the cultural infrastructure of societies across the globe. Education, which in recent years increasingly tied itself to notions of global culture and markets, is deeply threatened by these changes to the natural environment. This paper makes the case that the relationship between nature and culture in education requires a deep level analysis of the biological and physical substrate of human learning. Only with a sufficiently fundamental level of analysis can society reorganise its systems of learning and scientific inquiry to this rapidly changing environment. Drawing on evolutionary biology, we argue that institutional and individual structures and processes are recapitulations of evolutionary cellular development. Understanding the impact of Covid-19 on cells presents an invitation to consider the larger-scale cultural recapitulations of similar mechanisms and structures, and this has implications for the ways education might most effectively deploy technology. Whilst universities seek to maintain their existing structures, practices and business models, a cellular evolutionary approach points to the necessity for fundamental rethinking of intellectual life and learning. We consider the parameters of effective educational organisation in a post-Covid-19 world. As the richness and variety of the physical campus is removed, viable educational relationships will necessitate deeper intellectual connections and personal inquiries than are currently permitted in the transactional processes of education.

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“…Dutch individual suggested from a case study that he could voluntarily activate his ANS through a self-developed method involving meditation, exposure to cold temperatures, and breathing technique 3 . one another research experiment -mind over gene‖ revealed how mental exercise and meditation influence telomerase activity in subjects experiencing neuroticism, and these activities prevent telomere degradation 4 .…”

Section: Psychological Relation With Cancer Epigeneticsmentioning

confidence: 99%