Epigenetic mechanisms impacted by chronic stress across the rodent lifespan

Dion, Angie; Muñoz, Paula Torres; Franklin, Tamara B.

doi:10.1016/j.ynstr.2022.100434

Cited by 17 publications

(10 citation statements)

References 135 publications

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“…Epigenetic changes encompass a wide variety of chemical processes (e.g., in DNA methylation and post-transcriptional modifications on histone proteins) that dynamically regulate expression of many genes in diverse tissues ( Bowman and Poirier, 2015 ; Kuehner et al, 2019 ). The reviews of Dick and Chen (2021) and Dion et al (2022) compiled evidence on changes in the expression of DNA methyltransferases, histone deacetylases (HDACs) and the ten-eleven translocation (TET) family of dioxygenase enzymes after stress exposure and the molecular impact of these changes on behavioral adaptation in response to stress and on the unexposed offspring. Bartlett et al (2021) studied histone alterations due to acute glucocorticoid elevation in the mouse hippocampus and in a cell culture system.…”

Section: Molecular Effects Of Stressmentioning

confidence: 99%

Genetics and epigenetics of stress: New avenues for an old concept

Estruch

Tamashiro

Daskalakis

2023

Neurobiology of Stress

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Section: Molecular Effects Of Stressmentioning

confidence: 99%

Genetics and epigenetics of stress: New avenues for an old concept

Estruch

Tamashiro

Daskalakis

2023

Neurobiology of Stress

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“…Adolescents are more sensitive to the epigenetic and behavioral changes caused by stress exposure than adults (17). Differential expression of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), plays an important role in the regulation of epigenetic modi cation.…”

Section: Introductionmentioning

confidence: 99%

Aberrant plasma exosomal derived ceRNA networks as diagnosis biomarkers for adolescent major depressive disorder and its potential prediction for antidepressant

Liu

et al. 2023

Preprint

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Background: Major depressive disorder (MDD) in adolescence seriously endangers their mental and physical health and is associated with poor social and scholastic function. However, the diagnosis biomarkers for adolescent with MDD remain unclear. Methods：A total of 114 adolescent subjects were enrolled in this study, the comprehensive clinical and cognitive assessments were performed. Differential expressions of lncRNAs and mRNAs of plasma exosomes were screened by microarray assay. Two sets of ceRNA (lncRNAs-miRNAs-mRNAs) networks had been generated and candidate genes had been screened by bioinformatic analysis, and candidate genes were validated in cohort using qRT-PCR. Results：A total of 3752 differentially expressed lncRNAs and 1789 differentially expressed mRNAs were identified. AC156455.1, miR-126-5p, AAK1 and CCDC18AS1, miR-6835-5p, CCND2 were picked from each network as candidate genes. We found that the six candidate genes were differential expression between MDD patients and healthy controls, or before and after antidepressant treatment of MDD group. The expression levels of AAK1, CCDC18AS1 and miR6835 varied in efficacy after 8-week sertraline treatment. We also found that the expression of CCDC18AS1, miR-6835-5p, CCND2 (in the same network) at baseline could predicted antidepressant efficacy, which may be mediated through reducing suicidal ideation and improving cognitive function. Conclusion:Our study identified and validated the plasma exosome-derived ceRNA networks altered in adolescent with MDD, our findings provided potential diagnosis and therapeutic biomarkers for adolescent with MDD.

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“…Adolescents with MDD often experience persistent symptoms that continue into adulthood, imposing a greater burden when compared to those with MDD rst occurring in adulthood (4), including impaired social and academic functioning, elevated risk of physical illnesses, and substance abuse (5). Moreover, the risk of suicide among adolescents with MDD is alarmingly high, making it one of the primary causes of death in the 15-24 age group (6,7). Nevertheless, the etiology of adolescents with MDD remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Identification of Aberrant Plasma Exosomal Derived ceRNA Networks in Adolescent with Major Depressive Disorder

Liu

Zhang

et al. 2023

Preprint

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Major Depressive Disorder (MDD) during adolescence significantly jeopardizes both mental and physical well-being. However, the etiology underlying MDD in adolescents remains unclear. Our study enrolled a total of 114 adolescent participants who underwent comprehensive clinical and cognitive assessments. Differential expressions of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) within plasma exosomes were determined through microarray analysis. A total of 3752 dysregulated lncRNAs and 1789 dysregulated mRNAs were identified. Subsequently, two distinct sets of competitive endogenous RNA (ceRNA) networks were established. The candidate regulatory axes (AC156455.1/miR126-5p/AAK1 and CCDC18AS1/miR6835-5p/CCND2) were chosen from the ceRNA networks and subsequently validated within the cohort using quantitative real-time polymerase chain reaction (qRT-PCR). Our findings reveal that the candidate regulatory axes exhibit diverse expression patterns among both adolescents with MDD and healthy controls (HCs), both prior to and post-treatment in adolescents with MDD. Furthermore, the expression levels of AAK1, CCDC18AS1, and miR6835-5p exhibited significant differences between the response and non-response groups. Baseline expression level of CCDC18-AS1, miR-6835-5p and CCND2 could predict the therapeutic effect of sertraline, which may be achieved by reducing suicidal ideation and improving cognitive function. Our results may provide prospective insights into the underlying pathological mechanisms in adolescents with MDD.

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Epigenetic mechanisms impacted by chronic stress across the rodent lifespan

Cited by 17 publications

References 135 publications

Genetics and epigenetics of stress: New avenues for an old concept

Genetics and epigenetics of stress: New avenues for an old concept

Aberrant plasma exosomal derived ceRNA networks as diagnosis biomarkers for adolescent major depressive disorder and its potential prediction for antidepressant

Identification of Aberrant Plasma Exosomal Derived ceRNA Networks in Adolescent with Major Depressive Disorder

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