Epigenetic Markers to Predict Conversion From Gestational Diabetes to Type 2 Diabetes

Michalczyk, Agnes; Dunbar, James; Janus, Edward; Best, James D.; Ebeling, Peter R.; Ackland, Michael; Asproloupos, Dino; Ackland, M. Leigh

doi:10.1210/jc.2015-4206

Cited by 26 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Women with a history of GDM are at greater risk of developing type 2 diabetes after pregnancy. With this in mind, Michalczyk et al (38) analyzed several epigenetic markers during and after pregnancy in: women with GDM who subsequently developed type 2 diabetes (No. 6); women with GDM who did not develop type 2 diabetes after delivery (No.…”

Section: Epigenetic Studiesmentioning

confidence: 99%

Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus

et al. 2020

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is the most common metabolic complication of pregnancy, with a prevalence that has increased significantly in the last decade, coming to affect 12–18% of all pregnancies. GDM is believed to be the result of a combination of genetic, epigenetic and environmental factors. Following the identification of susceptibility genes for type 2 diabetes by means of genome-wide association studies, an association has also been demonstrated between some type 2 diabetes susceptibility genes and GDM, suggesting a partial similarity of the genetic architecture behind the two forms of diabetes. More recent genome-wide association studies, focusing on maternal metabolism during pregnancy, have demonstrated an overlap in the genes associated with metabolic traits in gravid and non-gravid populations, as well as in genes apparently unique to pregnancy. Epigenetic changes—such as DNA methylation, histone modifications and microRNA gene silencing—have also been identified in GDM patients. Metabolomics has been used to profile the metabolic state of women during pregnancy, based on the measurement of numerous low-molecular-weight metabolites. Measuring amino acids and conventional metabolites has revealed changes in pregnant women with a higher insulin resistance and high blood glucose levels that resemble the changes seen in non-gravid, insulin-resistant populations. This would suggest similarities in the metabolic profiles typical of insulin resistance and hyperglycemia whether individuals are pregnant or not. Future studies combining data obtained using multiple technologies will enable an integrated systems biology approach to maternal metabolism during a pregnancy complicated by GDM. This review highlights the recent knowledge on the impact of genetics and epigenetics in the pathophysiology of GDM and the maternal and fetal complications associated with this pathology condition.

show abstract

Section: Epigenetic Studiesmentioning

confidence: 99%

Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Michalczyk et al. () showed that, on the basis of histone methylation, it is possible to predict the risk of GDM. The results of the study conducted on 39 women suggest that the level of histone H3K27 and H3K4 dimethylation correlates with GDM progression to T2DM.…”

Section: Epigenetics Of Gdmmentioning

confidence: 99%

The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus

Rosik

Szostak

Machaj

et al. 2019

Annals of Human Genetics

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a heterogeneous group of disorders whose common trait is chronic hyperglycemia. Gestational diabetes mellitus (GDM) is one of the subtypes of DM that manifests during pregnancy. It is believed that 2%-5% of pregnancies worldwide are complicated with GDM, with the prevalence having significantly increased over the last decade. While the pathogenesis of the disease remains largely unknown, GDM is believed to be a result of interactions between genetic, epigenetic, and environmental factors. Linkage and association studies, including those that are genomewide, have allowed us to identify complex genetic and epigenetic mechanisms that lead to the development of GDM. Multiple common variants in candidate genes such as potassium inwardly rectifying channel subfamily J, member 11 (KCNJ11), glucokinase (GCK), or hepatocyte nuclear factor 1α (HNF1A) have been found to increase the disease risk. In this review, we provide a detailed overview of the current knowledge concerning the influence of genetics and epigenetics on the development of GDM. K E Y W O R D Sdiabetes mellitus, epigenetics, genetics, gestational diabetes mellitus 114

show abstract

“…Recent studies have attempted to identify epigenetic biomarkers that can be used to predict the on-set of T2DM following the occurrence of GDM [70][71][72] (Table 1). The studies of Wu et al [70], stand out because they identified maternal DNA methylation changes prior to the diagnosis of GDM; thereby pointing to specific genes (COPS8, PIL3R5, HAAO, CCDC124, and C5 or f34) that may be used as biomarkers for the on-set of GDM prior to its clinical diagnosis.…”

Section: Potential Epigenetic Biomarkers For Predicting Gestational Dmentioning

confidence: 99%

“…The studies of Wu et al [70], stand out because they identified maternal DNA methylation changes prior to the diagnosis of GDM; thereby pointing to specific genes (COPS8, PIL3R5, HAAO, CCDC124, and C5 or f34) that may be used as biomarkers for the on-set of GDM prior to its clinical diagnosis. Studying the epigenetic process of histone methylation, as opposed to DNA methylation, Michalczyk et al [71], studied the blood of GDM versus non-GDM mothers and determined that methylated H3K27 was significantly lower at 8-10 and 20 weeks postpartum in women with GDM who developed T2DM, compared with nondiabetic women. Likewise methylated H3K4 was significantly lower at 8-10 weeks postpartum in women with GDM who later developed T2DM compared with women who had GDM who did later develop the disease.…”

Section: Potential Epigenetic Biomarkers For Predicting Gestational Dmentioning

confidence: 99%

The Effect Gestational Diabetes has on DNA Methylation as Related to Fetal Development and the Outcomes of the Mother and Offspring

Sarras¹

2018

DMD

View full text Add to dashboard Cite

show abstract

Epigenetic Markers to Predict Conversion From Gestational Diabetes to Type 2 Diabetes

Abstract: The percentage of dimethylation of histones H3K27 and H3K4 varied with diabetic state and has the potential as a predictive tool to identify women who will convert from GDM to type 2 diabetes.

Cited by 26 publications

References 34 publications

Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus

Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus

The role of genetics and epigenetics in the pathogenesis of gestational diabetes mellitus

The Effect Gestational Diabetes has on DNA Methylation as Related to Fetal Development and the Outcomes of the Mother and Offspring

Contact Info

Product

Resources

About