Epigenetic Manifestation of Metabolic Syndrome and Dietary Management

Chaudhary, Nidhi; Nakka, Kiran; Maulik, Nilanjana; Chattopadhyay, Samit

doi:10.1089/ars.2011.4387

Cited by 16 publications

(12 citation statements)

References 358 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the responsiveness of epigenetic marks to dietary factors, there are numerous studies that try to identify new plant compounds with effects on the epigenetic molecular processes in order to apply them in obesity prevention and treatment (Chaudhary et al, 2012). In a near future, we could talk about "epigenetic foods" that will be a kind of functional foods that contain bioactive compounds with capacity to modulate miRNA expression, DNA methylation or histone modifications.…”

Section: Polyphenols and Other Plant Compoundsmentioning

confidence: 99%

“…Some of them could have some benefits in the treatment or prevention of metabolic disorders. Moreover, there is currently great interest in identifying new plant compounds with epigenetic properties that could be applied as therapeutic agents in obesity (Chaudhary et al, 2012). So, numerous plant extracts and compounds are being screened for modulating histone modifying enzymes and DNMTs.…”

Section: Polyphenols and Other Plant Compoundsmentioning

confidence: 99%

See 1 more Smart Citation

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

245

160

View full text Add to dashboard Cite

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

show abstract

Section: Polyphenols and Other Plant Compoundsmentioning

confidence: 99%

Section: Polyphenols and Other Plant Compoundsmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

245

160

View full text Add to dashboard Cite

show abstract

“…As DAG is a major regulator of many important biological processes, its abundance in cells might be tightly controlled, which is a key role for DGK [9]. Expression of the gene coding for DGK isoforms such as DGKZ, may be closely regulated accordingly by epigenetic mechanisms, influenced by environmental factors such as diet [42]. Through excessive intake in food, an accumulation of TG can lead to fat storage in ectopic sites, which is associated with dyslipidemia and other obesity-related metabolic complications such as hypertension, glucose intolerance [43], and insulin resistance [44].…”

Section: Discussionmentioning

confidence: 99%

The rare allele of DGKZ SNP rs10838599 is associated with variability in HDL-cholesterol levels among severely obese patients

Bégin¹,

Guénard²,

Thewis³

et al. 2016

Integr Obesity Diabetes

View full text Add to dashboard Cite

Introduction: Diacylglycerol kinase-zeta, one of the ten isoforms of DGKs expressed in mammals is an important enzyme of lipid metabolism. It catalyzes the interconversion of diacylglycerol and phosphatidic acid, two major second messengers. Its gene DGKZ has been previously identified as being overexpressed and undermethylated in visceral adipose tissue of patients with (MetS+) versus without (MetS-) the metabolic syndrome (MetS).

show abstract

“…Growing body of studies has been conducted to elucidate the molecular effects of dietary constituents on genome-wide multiple-level gene expression and metabolic profiles, exhibiting the arrival of post-genomic era in nutrition and cancer research (36–38). The results from these studies are exciting and the new biomarkers have been identified through the dietary intervention studies (39,40). Emerging evidence has demonstrated that the interactions between genes/miRNAs and nutrients or nutraceuticals are significantly implicated in the processes of cancer development and progression (41,42).…”

Section: Nutrients and Nutraceuticals For Pancreatic Cancer Preventionmentioning

confidence: 99%

The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy

Li¹,

Go²,

Sarkar³

2015

Pancreas

View full text Add to dashboard Cite

Pancreatic cancer is one of the most aggressive malignancies in US adults. The experimental studies have found that antioxidant nutrients could reduce oxidative DNA damage, suggesting that these antioxidants may protect against pancreatic carcinogenesis. Several epidemiologic studies showed that dietary intake of antioxidants was inversely associated with the risk of pancreatic cancer, demonstrating the inhibitory effects of antioxidants on pancreatic carcinogenesis. Moreover, nutraceuticals, the anti-cancer agents from diet or natural plants, have been found to inhibit the development and progression of pancreatic cancer through the regulation of cellular signaling pathways. Importantly, nutraceuticals also up-regulate the expression of tumor suppressive miRNAs and down-regulate the expression of oncogenic miRNAs, leading to the inhibition of pancreatic cancer cell growth and pancreatic Cancer Stem Cell (CSC) self-renewal through modulation of cellular signaling network. Furthermore, nutraceuticals also regulate epigenetically deregulated DNAs and miRNAs, leading to the normalization of altered cellular signaling in pancreatic cancer cells. Therefore, nutraceuticals could have much broader use in the prevention and/or treatment of pancreatic cancer in combination with conventional chemotherapeutics. However, more in vitro mechanistic experiments, in vivo animal studies, and clinical trials are needed to realize the true value of nutraceuticals in the prevention and/or treatment of pancreatic cancer.

show abstract

Epigenetic Manifestation of Metabolic Syndrome and Dietary Management

Cited by 16 publications

References 358 publications

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

The rare allele of DGKZ SNP rs10838599 is associated with variability in HDL-cholesterol levels among severely obese patients

The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy

Contact Info

Product

Resources

About