Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs
A. Tomar,
M. Gomez-Velazquez,
R. Gerlini
et al.
Abstract:Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs)1, which influences offspring development and adult phenotypes1–7. Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood8. Here we used two distinct paradigms of preconception acute high-fat diet to dissect epididymal versus testicular contributions to the sperm sncRNA pool and offspring health. We show that epididymal spermatozoa, but not developing germ cells, … Show more
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